Propylparaben induces apoptotic cell death in human placental BeWo cells via cell cycle arrest and enhanced caspase-3 activity

Kim, Mi Jin; Kim, Chulhong; An, Mi-Jin; Lee, Ju‐Hyun; Shin, Geun-Seup; Hwang, Jong Yeon; Park, Jin‐Hong; Song, Minseok; Woo, Ho-Young; Kim, Yeong-hwa; Rhee, Sangmyung; Kim, Jung-Woong

doi:10.1007/s13273-019-00062-9

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…As such, the effects of environmental hazardous substances on the human body have been studied in various ways 7,8 . In particular, multi‐omics research that considers various aspects to determine the causal relationship between diseases has attracted attention 9 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of multi‐omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances

Koh

Kim

et al. 2021

Environmental Toxicology

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Environmentally hazardous substances and exposure to these can cause various diseases. Volatile organic compounds can easily evaporate into the atmosphere, thereby exerting toxic effects through either the skin or respiratory tract exposures. Toluene, a neurotoxin, has been widely used in various industries. However, it has a detrimental effect on the nervous system (such as hallucinations or memory impairment), while data on the mechanism underlaying its harmful effects remain limited. Therefore, this study investigates the effect of toluene on the nervous system via epigenetic and genetic changes of toluene‐exposed individuals. We identified significant epigenetic changes and confirmed that the affected abnormally expressed genes negatively influenced the nervous system. In particular, we confirmed that the miR‐15 family, upregulated by toluene, downregulated ABL2, which could affect the R as signaling pathway resulting in neuronal structural abnormalities. Our study suggests that miR‐15a‐5p, miR‐15b‐5p, miR‐16‐5p, miR‐301a‐3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene.

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Section: Introductionmentioning

confidence: 99%

Analysis of multi‐omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances

Koh

Kim

et al. 2021

Environmental Toxicology

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“…EDs can produce an indirect effect rather than a direct effect on hormone receptors. Kim et al (2019) reported that PrPB (0.25‐0.5 m m ) decreases the viability of human placental BeWo cells by apoptosis. Samarasinghe et al (2018) reported that MePB (13 m m ) decreases sperm motility, and that the mixture of PBs (1‐4 m m ) decreases sperm viability.…”

Section: Introductionmentioning

confidence: 99%

Effects of methylparaben on in vitro maturation of porcine oocytes

Barajas-Salinas

Ducolomb

Betancourt

et al. 2020

J of Applied Toxicology

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Parabens (PBs) are compounds widely used in industry for food and personal care products as antimicrobials and preservatives. Their indiscriminate use has resulted in their detection in different ecosystems so that humans and other organisms are highly exposed. Methylparaben (MePB), compared with other PBs, is mostly detected in food, personal care and baby care products. PBs could be linked to the generation of hormonal disorders and fertility impairment since their recent classification as endocrine disruptors. The knowledge of the effects that MePB can exert is of great importance as, in terms of reproduction, information is limited. Therefore, the objective of the present study was to evaluate the effect of MePB on porcine oocyte viability and in vitro maturation (IVM), as well as to determine the lethal concentration at 50% (LC 50) and the maturation inhibition concentration at 50% (MIC 50). Oocytes were exposed to different MePB concentrations 0 (control), 50, 100, 500, 750 and 1000 μM during 44 h of IVM. Cytoplasmic alterations and reduced cumulus cell expansion were observed in oocytes exposed to MePB; however, viability was not affected. In addition, oocyte maturation decreased in a concentration-dependent manner after exposure to MePB. The estimated LC 50 was 2028.38 μM, whereas MIC 50 was 780.31 μM. To our knowledge, this is the first study that demonstrates that MePB altered porcine oocyte morphology, and caused a reduction in cumulus cell expansion, both of which resulted in decreased oocyte maturation. Therefore, MePB exposure may be one of the factors involved in fertility impairment in mammals, including that of humans.

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“…EDs can produce an indirect effect rather than a direct effect on hormone receptors. Kim et al (2019) reported that PrPB (0.25-0.5 mM) decreases the viability of human placental BeWo cells by apoptosis. Samarasinghe et al (2018) reported that MePB (13 mM) decreases sperm motility, and that the mixture of PBs (1-4 mM) decreases sperm viability.…”

Section: Effects Of Methylparaben On In Vitro Maturation Of Porcine Oocytes 1 | Introductionmentioning

confidence: 99%

Efecto del metil-parabeno durante la maduración in vitro de ovocitos de cerdo

Salinas

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Propylparaben induces apoptotic cell death in human placental BeWo cells via cell cycle arrest and enhanced caspase-3 activity

Cited by 11 publications

References 29 publications

Analysis of multi‐omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances

Analysis of multi‐omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances

Effects of methylparaben on in vitro maturation of porcine oocytes

Efecto del metil-parabeno durante la maduración in vitro de ovocitos de cerdo

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