Propylene Glycol Liposomes as a Topical Delivery System for Miconazole Nitrate: Comparison with Conventional Liposomes

El‐Moslemany, Riham M.; Abdallah, Ossama Y.; El-Khordagui, Labiba K.; Khalafallah, Nawal

doi:10.1208/s12249-012-9783-6

Cited by 113 publications

(61 citation statements)

References 33 publications

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“…(6) Transdermal delivery system that has a metallic component (usually aluminum) in their waterproof layer can cause burns if they absorb heat. Products are not always labeled with a warning if they contain metals (Elmoslemany et al, 2012).…”

Section: Various Issues With Transdermal and Topical Delivery Systemmentioning

confidence: 99%

Permeation enhancer strategies in transdermal drug delivery

et al. 2014

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Today, $74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive techniques of drug delivery. Several important advantages of transdermal drug delivery are prevention from hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Human skin surface, as a site of drug application for both local and systemic effects, is the most eligible candidate available. New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for the transdermal delivery of troublesome drugs. This review article covers most of the new active transport technologies involved in enhancing the transdermal permeation via effective drug delivery system.

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Section: Various Issues With Transdermal and Topical Delivery Systemmentioning

confidence: 99%

Permeation enhancer strategies in transdermal drug delivery

et al. 2014

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“…14 Ethosomes are a novel type of liposomes containing a high concentration of shortchain alcohols, including ethanol, propylene glycol, or even a mixture of ethanol and propylene glycol. [15][16][17] The addition of ethanol improves the deformability of vesicles, thus overcoming some of the disadvantages of the conventional liposomes, but also carries the risk of skin irritation.…”

Section: Introductionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.

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“…The malleable liposomes are thought to permeate facilely into the intercellular lipid bilayers, thereby enhancing drug absorption into the skin. 27 It is also proposed that the soft liposomes interact strongly with SC lipids, 25,28 creating a cutaneous reservoir for drug delivery. Follicular accumulation is generally more efficient with nanoparticles of ,300 nm.…”

Section: Discussionmentioning

confidence: 99%

Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting

Hsu¹,

Yang²,

Sung³

et al. 2017

IJN

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Pathogens usually invade hair follicles when skin infection occurs. The accumulated bacteria in follicles are difficult to eradicate. The present study aimed to assess the cutaneous and follicular delivery of chloramphenicol (Cm)-loaded liposomes and the antibacterial activity of these liposomes against methicillin-resistant Staphylococcus aureus (MRSA). Skin permeation was conducted by in vitro Franz diffusion cell. The anti-MRSA potential was checked using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), a well diffusion test, and intracellular MRSA killing. The classic, dimyristoylphosphatidylcholine (DMPC), and deoxycholic acid (DA) liposomes had a vesicle size of 98, 132, and 239 nm, respectively. The incorporation of DMPC or DA into the liposomes increased the bilayer fluidity. The malleable vesicles containing DMPC and DA showed increased follicular Cm uptake over the control solution by 1.5- and 2-fold, respectively. The MIC and MBC of DA liposomes loaded with Cm were 62.5 and 62.5–125 μg/mL, comparable to free Cm. An inhibition zone about 2-fold higher was achieved by DA liposomes as compared to the free control at a Cm dose of 0.5 mg/mL. DA liposomes also augmented antibacterial activity on keratinocyte-infected MRSA. The deformable liposomes had good biocompatibility against keratinocytes and neutrophils (viability >80%). In vivo administration demonstrated that DA liposomes caused negligible toxicity on the skin, based on physiological examination and histology. These data suggest the potential application of malleable liposomes for follicular targeting and the treatment of MRSA-infected dermatologic conditions.

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Propylene Glycol Liposomes as a Topical Delivery System for Miconazole Nitrate: Comparison with Conventional Liposomes

Cited by 113 publications

References 33 publications

Permeation enhancer strategies in transdermal drug delivery

Permeation enhancer strategies in transdermal drug delivery

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting

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