Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity

Holdstock, Douglas; Misiewicz, J. J.; Smith, T.; Rowlands, E. N.

doi:10.1136/gut.11.2.91

Cited by 220 publications

(73 citation statements)

References 24 publications

(28 reference statements)

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“…For a given drug the rate of absorption is modified by a number of factors including particle size; alimentary motility; mucosal blood flow; digestive secretions and intestinal contents (Smythe, 1964 (Holdstock, Misiewicz, Smith & Rowlands, 1970) Bell, 1973). It is of note that for the latter two drugs these effects were fully appreciated only after they had been in use for some time and, certainly in the case of L-dopa, the therapeutic implications are of some importance.…”

Section: Discussionmentioning

confidence: 99%

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

VOLANS

1974

Brit J Clinical Pharma

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The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non‐fasting states. Moderate activity resulted in no significant changes in absorption compared with that at rest. In non‐fasting subjects the absorption was reduced but this reduction was attenuated with time until after 60 min the plasma levels were similar. There was no interaction between the resting/non‐resting and fasting/non‐fasting absorption.

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Section: Discussionmentioning

confidence: 99%

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

VOLANS

1974

Brit J Clinical Pharma

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“…5,22 Range of motion exercises prior to the bowel program may help to facilitate evacuation in these individuals. 22,60 Polypharmacy may increase the risk of constipation, especially in older individuals, 34 and constipation as a drug side-e ect may be substantially under-reported in patients with SCI. Benzodiazepines have not previously been shown to increase the risk of constipation in non-injured subjects 33,37 and this study ®nding may be confounded by increased administration to individuals who are Frankel grade A or B.…”

Section: Discussionmentioning

confidence: 99%

Constipation-related symptoms and bowel program concerning individuals with spinal cord injury

Harari

Sarkarati²,

Gurwitz

et al. 1997

Spinal Cord

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Purpose. To determine the prevalence of constipation-related symptoms in individuals with chronic spinal cord injury (SCI), to describe the bowel program as reported by patients and including use of bowel medications and evacuation techniques, and to examine the clinical, functional and pharmacological risks of di culty with evacuation. Patients and Methods. This is a cross-sectional study of all in-patients at least 3 months beyond acute injury, on the West Roxbury/Brockton VAMC SCI Service, during a 10 month period (n=197). Clinical, functional, and medication data were abstracted from medical and nursing records. Individual interviews were conducted with all available participants (n=161, 82%) regarding bowelrelated symptoms and treatment over the previous 1 month period. The study de®nition of di culty with evacuation was spending more than 1 h per episode of bowel evacuation. Results. Forty-one percent of the 161 interview responders spent more than 1 h on bowel evacuation, 50% reported abdominal distension and 38% reported abdominal pain, 27% reported headaches or sweats relieved by having a bowel movement, and 33% reported fecal incontinence at least once a month. The bisacodyl suppository was the most commonly used laxative agent, while docusate was the most popular oral agent. Subjects with di culty with evacuation (n=66) were compared with those who spent less than 1 h on evacuation (n=95). Factors associated with di culty with evacuation were tetraplegia, Frankel grade A/B, laxative use, polypharmacy, previous urinary outlet surgery, and symptoms of abdominal pain and distension. Conclusion. Constipation-related symptoms are highly prevalent in individuals with spinal cord injury, despite considerable laxative use. Our ®ndings suggest that di culty with evacuation can be predicted on the basis of a patient's clinical pro®le.

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“…The reasons were not known, but vibrations and the cramped sitting posture were believed to be partial causes. Holdstock et al (1970) considered that physical activity stimulates the colon peristalsis. Little physical activity, as in prolonged sitting, can therefore cause constipation.…”

Section: Internal Organsmentioning

confidence: 99%

Industrial seating and spinal loading

Eklund

1988

Clinical Biomechanics

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Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity

Cited by 220 publications

References 24 publications

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

Effects of Food and Exercise on the Absorption of Effervescent Aspirin

Constipation-related symptoms and bowel program concerning individuals with spinal cord injury

Industrial seating and spinal loading

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