Effects of Food and Exercise on the Absorption of Effervescent Aspirin

Abstract

The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non‐fasting states. Moderate activity resulted in no significant changes in absorption compared with that at rest. In non‐fasting subjects the absorption was reduced but this reduction was attenuated with time until after 60 min the plasma levels were similar. There was no interaction between the resting/non‐resting and fasting/non‐fasting absorption.

The effect of metoclopramide on the absorption of effervescent aspirin in migraine.

“…Little is known about changes in drug absorption with age in adults but no clinically significant alterations have been observed in geriatric patients (Hall, 1973) and it, therefore, seems unlikely that the small age differences observed here would have any effect. Blood salicylate levels demonstrate an inverse correlation with body weight in males (Cummings & Martin, 1964) and the author's observations in female subjects suggest a similar effect although the overall mg/kg levels were lower (Volans, 1974a). These findings would suggest that the plasma salicylate levels in group B were likely to be higher than those in Group A but in practice, whilst the results differed between the groups in the acute attack, there was no significant difference between the control observations in the two groups.…”

“…All gave informed consent to the investigation and all were considered to fulfil the diagnostic criteria of migraine (World Federation of Neurology Research Group in Migraine and Headache, 1970). Since it was found that most patients attending the clinic had not taken food for at least 4 h (Volans, 1974b) and since food has been shown to reduce the absorption of effervescent aspirin (Volans, 1974a), patients who had eaten within that time were excluded from the study. Patients were also not included if there was any evidence of other disease, if there was any history of dyspepsia or if analgesics or anti-emetic drugs had been taken within 24 h prior to arrival at the clinic.…”

Backtracking booze with Bayes‐the retrospective interpretation of blood alcohol data.

“…In addition, ethanol may slow its own absorption by delaying gastric empyting (Wilkinson et al, 1977). External factors such as exercise (Volans, 1974) or pain (Nimmo, 1976) may also delay gastric emptying and hence the rate of ethanol absorption. Several authors (Sedman et al, 1976;Taberner, 1988) (Beal & Sheiner, 1980).…”

The Influence of Thiethylperazine on the Absorption of Effervescent Aspirin in Migraine

“…In his initial studies on the absorption of effervescent aspirin in fasting normal volunteer subjects, Volans (1974a) suggested that the criterion for poor absorption should be established at the lower 2.5% confidence limit of plasma salicylate levels obtained from his normal controls at 30 min-that is 4.42 mg/100 ml. Eight out of the sixteen patients treated with thiethylperazine and aspirin achieved levels less than this at 30 min and can thus be classified as poor absorbers.…”

“…The present study was designed to demonstrate the effect of a phenothiazine, thiethylperazine, on the absorption of aspirin during a migraine attack and to compare its efficacy with an anti-emetic known to stimulate gastrointestinal motility, namely metoclopramide. (Volans, 1974a). The patients were not allowed to rest in the left lateral position as this is known to reduce the rate of drug absorption (Truitt & Morgan, 1964;Martin, 1971 …”