Proprotein convertase subtilisin kexin type 9 and main artery atherosclerosis in patients with arterial hypertension

Vukolova, Yulia; Губарева, И. В.; Galati, Giuseppe; Germanova, Olga

doi:10.23736/s2724-5683.22.06008-2

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…24 Recently, PCSK9 inhibitors have attracted considerable attention. 25 Gu et al 26 used the simulation approach to evaluate the effect of various lipid-lowering therapies on LDL-C improvement in very-high-risk patients with ASCVD, and their results showed that PCSK9 inhibitors could be useful for most patients to achieve the LDL-C goal. However, due to the high prices of PCSK9 inhibitors, the indications of PCSK9 inhibitors need to be considered.…”

Section: Discussionmentioning

confidence: 99%

A Practical Statin Recommendation System Based on Real-World Data to Improve LDL-C Management in Secondary Prevention

Zhang

Liu

et al. 2023

Journal of Cardiovascular Pharmacology

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:Statins are considered the cornerstone of secondary prevention in patients with atherosclerotic cardiovascular disease (ASCVD). However, many patients fail to achieve the guide-recommended goal of low-density lipoprotein cholesterol (LDL-C) after statin monotherapy, leading to a high residual risk of cardiovascular events. Owing to individual differences in statin therapy, it is possible first to consider changing the type of statin before adding nonstatin medications in certain patients to improve LDL-C management. We developed and evaluated a statin recommendation system using real-world data. Ensemble learning was performed to develop the recommendation system that integrated the output results of support vector machines (SVM) and the similarity of patients. Model performance was assessed to investigate whether treatment according to the recommended model would increase the proportion of patients with the primary end point. Finally, a total of 3510 patients were enrolled in the development and validation of the recommender system. Of them, 1240 patients received atorvastatin (35.3%), 1714 patients received rosuvastatin (48.8%), and 556 patients received pitavastatin (15.8%). The statin recommendation system could significantly improve LDL-C target rate achievement in the recommended treatment group compared with the nonrecommended treatment group in the validation set (50.8% vs. 31.5%, P < 0.001). This study demonstrated that the statin recommendation system could significantly improve the achievement of LDL-C goals in ASCVD patients, providing a new approach to improve LDL-C management.

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Section: Discussionmentioning

confidence: 99%

A Practical Statin Recommendation System Based on Real-World Data to Improve LDL-C Management in Secondary Prevention

Zhang

Liu

et al. 2023

Journal of Cardiovascular Pharmacology

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“…Finally, to further widen the study findings, it would be desirable to project a similar LLT simulation on very high risk patients defined in accordance with the more stringent LDL cholesterol target recommended by the 2019 European Society of Cardiology guidelines and other experts (,55 mg/dL). 15,16 In conclusion, the study conducted by Deo et al convincingly proves the efficacy of intensive LLT, especially when bempedoic acid is a part of the therapeutic combination, in patients undergoing CABG at very high risk of CV events recurrence. The paper embraces the timely need of using computational algorithms to promptly predict therapies efficacy and patients' outcomes, but it fatally pays the penalty of presenting a computerized model of CV prognosis, burdened by the use of imputation methods, rather than real-life follow-up.…”

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confidence: 84%

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confidence: 99%

Step-wise Lipid-Lowering Therapy: Thinking Beyond the Guidelines

Pingitore

Spadafora

Biondi‐Zoccai

et al. 2023

Journal of Cardiovascular Pharmacology

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“…Проведены инструментальные исследования: УЗДГ БЦС с определением толщины комплекса интима-медиа (ТКИМ) и процента стеноза сонных артерий по диаметру (с использованием международных шкал ESCT, NASCET, St.Mary's ratio); КАГ на ангиографическом комплексе General Electric Innova 3100 [10,11].…”

Section: материалы и методыunclassified

Improvement of quality of life indicators in patients with metabolic syndrome after correction of hemodynamically significant coronary stenoses and dyslipidemia

Vukolova,

Gubareva,

Germanova

et al. 2024

ECG

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It is known that metabolic syndrome is currently the leading cause of the development of cardiovascular pathology, which occupies a leading position in the structure of mortality not only in the Russian population, but also in the world. The prevalence of MS is growing, which is associated with stressful professions, eating disorders. The presence of MS is associated with arterial hypertension and atherosclerosis of the arteries of any localization. In this regard, the purpose of our study was to study the quality of life in patients with MS, depending on the severity of coronary atherosclerosis. Materials and methods: The study included 239 patients (142 men, 97 women) with MS with atherosclerosis of the coronary and carotid arteries. The number of subjects in group 1 (n=141), of which 101 were men and 40 were women. The second group consisted of 84 male and 14 female patients (n=98). The control group consisted of 70 people (27 men, 43 women) with grade 1-3 hypertension. The age of the subjects was 31-56 years. All patients underwent: collection of complaints and anamnesis, assessment of body mass index (BMI); determination of the lipid spectrum, blood glucose, glycated hemoglobin. Microalbuminuria and glomerular filtration rate were determined. Instrumental studies were carried out: ultrasound examination of brachiocephalic vessels with determination of the thickness of the intima-media complex and the percentage of carotid artery stenosis; coronary angiography on the General Electric Innova 3100 angiographic complex. Based on the results of coronary angiography, the patients were divided into two subgroups: group 1 - with coronary artery stenosis of less than 50% (n=141), group 2 - with stenosis of 50% or more (n=98), group 3 (control) without stenotic lesions of the coronary arteries. A non-specific questionnaire “SF-36 Health Status Survey” was used to assess the quality of life. Results: assessing physical functioning and mental health, there was a significant decrease in these indicators in patients of group 2, in whom, according to coronary angiography, hemodynamically significant coronary artery stenoses were diagnosed, a strong correlation (r=0.730; p=0.005) was revealed between deterioration in quality of life and hemodynamically significant stenosis of the carotid and coronary arteries. Restriction of physical activity and reduction of daily activities were more significant in group 2 compared to groups 1 and 3. The feeling of uncertainty with restless expectation and fears, as well as a feeling of depression prevailed in men. However, patients after percutaneous coronary intervention, as well as with lipidogram correction, assessed the quality of life with some restriction of physical activity, but with significant social functioning. Conclusions: hemodynamically significant atherosclerosis of the carotid and coronary arteries is a predictor of deterioration in the quality of life, especially in men. The use of the international questionnaire “SF-36 Health Status Survey” is appropriate for assessing the health and vital activity in patients with MS and hypertension, with signs of atherosclerosis. The interaction of a cardiologist, an endocrinologist and a psychotherapist are justified for the most optimal management of patients with comorbid pathology.

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Proprotein convertase subtilisin kexin type 9 and main artery atherosclerosis in patients with arterial hypertension

Cited by 4 publications

References 27 publications

A Practical Statin Recommendation System Based on Real-World Data to Improve LDL-C Management in Secondary Prevention

A Practical Statin Recommendation System Based on Real-World Data to Improve LDL-C Management in Secondary Prevention

Step-wise Lipid-Lowering Therapy: Thinking Beyond the Guidelines

Improvement of quality of life indicators in patients with metabolic syndrome after correction of hemodynamically significant coronary stenoses and dyslipidemia

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