Proprioceptor Pathway Development Is Dependent on MATH1

Bermingham, Nessan A.; Hassan, Bassem A.; Wang, Vincent Y.; Fernández, Michael; Banfi, Sandro; Bellen, Hugo J.; Fritzsch, Bernd; Zoghbi, Huda Y.

doi:10.1016/s0896-6273(01)00305-1

Cited by 291 publications

(356 citation statements)

References 36 publications

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“…These overlapping expression patterns are similar to those of Math1 (Atoh1) and Lhx2/9 in the mouse spinal cord (Helms and Johnson, 1998;Caspary and Anderson, 2003). In the Math1 mutant mouse, the Lhx2/9(ϩ) neurons in the spinal cord and hindbrain neurons derived from the rhombic lip fail to develop (Bermingham et al, 2001;Wang et al, 2005). Thus, we injected the antisense morpholino (MO) against atoh1a transcripts into zebrafish embryos to examine whether Atoh1a is required for the development of zn-5(ϩ)Lhx2/9(ϩ) and/or Gad1/2(ϩ) neurons.…”

Section: Two Distinct Classes Of Neurons In the Dorsal Hindbrain Basesupporting

confidence: 57%

“…Thus, we injected the antisense morpholino (MO) against atoh1a transcripts into zebrafish embryos to examine whether Atoh1a is required for the development of zn-5(ϩ)Lhx2/9(ϩ) and/or Gad1/2(ϩ) neurons. In the atoh1a MO-injected embryos, similarly to the case of Math1 knockout in the mouse spinal cord (Bermingham et al, 2001), the expression of lateral Lhx2/9 (Fig. 1G,H,J,L; n ϭ 10 from two independent experiments) and the zn-5 antigen ( Fig.…”

Section: Two Distinct Classes Of Neurons In the Dorsal Hindbrain Basementioning

confidence: 69%

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Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Sassa

Aizawa

Okamoto

2007

Developmental Dynamics

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The dorsal hindbrain includes distinct classes of neurons for processing various sensory stimuli, but the developmental aspects of these neurons remain largely unknown. We identify here two distinct classes of neurons in the dorsal hindbrain of developing zebrafish: (1) neurons that express the inhibitory neuronal marker Gad1/2, and (2) neurons that express the zn-5 antigen and Lhx2/9 and require the basic helix-loop-helix transcription factor Atoh1a for development. Neurons were traced to their axon terminals by expressing green fluorescent protein using the Gal4VP16-UAS (UAS, upstream activating sequences) system in combination with the promoter/enhancer regions of gad2 for the Gad1/2(؉) neurons and zic1 for the zn-5(؉)Lhx2/9(؉) neurons. The Gad1/2(؉) neurons projected to the contralateral hindbrain, while the zn-5(؉)Lhx2/9(؉) neurons projected to the contralateral midbrain torus semicircularis, suggesting a role in auditory and lateral line sensory processing. Comparison of these projections with those from the cochlear nuclei to the inferior colliculus in mammals suggests similarities across vertebrate species. Developmental Dynamics 236:706 -718, 2007.

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Section: Two Distinct Classes Of Neurons In the Dorsal Hindbrain Basesupporting

confidence: 57%

Section: Two Distinct Classes Of Neurons In the Dorsal Hindbrain Basementioning

confidence: 69%

Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Sassa

Aizawa

Okamoto

2007

Developmental Dynamics

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“…The most closely related bHLH factor to Math5 is Math1, which is expressed in several progenitor populations that give rise to components of the proprioceptive system throughout the nervous system. These include inner ear hair cells, whisker barrels, the rhombic lip, and the dorsal spinal cord (Akazawa et al, 1995;Ben-Arie et al, 2000;Bermingham et al, 2001;Machold and Fishell, 2005;Wang et al, 2005). Sensory inputs, including Merkel cells in whisker barrels and hair cells in the inner ear, transmit positional information to the brain, which is then processed in a complex circuit including the pontine nuclei, cerebellum, and cerebral cortex (Bermingham et al, 2001).…”

Section: Math5-gfp1 Is Expressed In a Subset Of Math1 Expression Domainsmentioning

confidence: 99%

“…These include inner ear hair cells, whisker barrels, the rhombic lip, and the dorsal spinal cord (Akazawa et al, 1995;Ben-Arie et al, 2000;Bermingham et al, 2001;Machold and Fishell, 2005;Wang et al, 2005). Sensory inputs, including Merkel cells in whisker barrels and hair cells in the inner ear, transmit positional information to the brain, which is then processed in a complex circuit including the pontine nuclei, cerebellum, and cerebral cortex (Bermingham et al, 2001). Since we observed Math5-GFP expression in several regions known to express Math1, we hypothesized that Math5-GFP1 and Math1 are expressed in the same cell lineages.…”

Section: Math5-gfp1 Is Expressed In a Subset Of Math1 Expression Domainsmentioning

confidence: 99%

“…Atonal is also expressed in chordotonal organs, which process proprioceptive information during larval movement, and in Johnston's organ that functions analogously to the mammalian auditory system (Jarman et al, 1993). Math1 is expressed in several components of the proprioceptive pathway in mouse, and in auditory hair cells of the inner ear (Bermingham et al, 1999;Bermingham et al, 2001). Here we report Math5 LacZ expression in the cochlear nucleus, a component of the auditory system.…”

Section: Regulatory Conservation In the Evolutionary Divergence Of Bhmentioning

confidence: 99%

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Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes

Hufnagel

Riesenberg

Saul

et al. 2007

Molecular and Cellular Neuroscience

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Retinal ganglion cell genesis requires the proneural bHLH transcription factor Math5 (Atoh7), but little is known about the regulatory elements that control its expression. Here, we investigate Math5 gene regulation using transgenic mice. These mice express GFP in the prenatal retina, livelabeling RGC axon migration and innervation of the brain. Unexpectedly, these Math5-GFP transgenes are also found in Math1 expression domains throughout the nervous system, intriguing since Math5 and Math1 normally exhibit nonoverlapping expression. Furthermore, Math5-GFP and Math1 are regulated similarly, by both Pax6 and Math1 itself, in the lower rhombic lip and dorsal spinal cord. We also show that Pax6 binds to particular Math5 and Math1 regulatory sequences in vitro. Together these data suggest that these atonal semi-orthologues may share conserved regulatory elements that are normally silent in the Math5 gene.

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Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: Review and new results

2003

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Merkel nerve endings are mechanoreceptors in the mammalian skin. They consist of large, pale cells with lobulated nuclei forming synapse-like contacts with enlarged terminal endings of myelinated nerve fibers. They were first described by F.S. Merkel in 1875. They are found in the skin and in those parts of the mucosa derived from the ectoderm. In mammals (apart from man), the largest accumulation of Merkel nerve endings is found in whiskers. In all vertebrates, Merkel nerve endings are located in the basal layer of the epidermis, apart from birds, where they are located in the dermis. Cytoskeletal filaments consisting of cytokeratins and osmiophilic granules containing a variety of neuropeptides are found in Merkel cells. In anseriform birds, groups of cells resembling Merkel cells, with discoid nerve terminals between cells, form Grandry corpuscles. There has been controversy over the origin of Merkel cells. Results from chick/quail chimeras show that, in birds, Merkel cells are a subpopulation of cells derived from the neural crest, which thus excludes their development from the epidermis. Most recently, also in mammals, conclusive evidence for a neural crest origin of Merkel cells has been obtained. Merkel cells and nerve terminals form mechanoreceptors. Calcium ions enter Merkel cells in response to mechanical stimuli, a process which triggers the release of calcium from intracellular stores resulting in exocytosis of neurotransmitter or neuromodulator. Recent results suggest that there may be glutamatergic transmission between Merkel cell and nerve terminal, which appears to be essential for the characteristic slowly adapting response of these receptors during maintained mechanical stimuli. Thus, we are convinced that Merkel cells with associated nerve terminals function as mechanoreceptor cells. Cells in the skin with a similar appearance as Merkel cells, but without contact to nerve terminals, are probably part of a diffuse neuroendocrine system and do not function as mechanoreceptors. Probably these cells, rather than those acting as mechanoreceptors, are the origin of a highly malignant skin cancer called Merkel cell carcinoma. Anat Rec Part A 271A: 225-239, 2003.

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Proprioceptor Pathway Development Is Dependent on MATH1

Cited by 291 publications

References 36 publications

Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems

Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes

Friedrich Sigmund Merkel and his “Merkel cell”, morphology, development, and physiology: Review and new results

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