Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder

Szeleszczuk, Łukasz; Frączkowski, Dawid

doi:10.3390/ijms231710099

Cited by 16 publications

(9 citation statements)

References 186 publications

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“…However, comparing our findings with previous studies conducted in Saudi Arabia, it was found that self-medication was prevalent among 60.5% of the participants and that 63.2% of them had taken propranolol at a dose of < 10 mg [ 13 , 21 , 24 , 26 ]. The highest reported dose was 40 mg, which was close to the highest reported dose in our results [ 28 ]. Only 15.8% (n=6) of participants at Umm Al-Qura University increased their dosage without a physician’s instructions; according to Alkhatabi et al, 29.4% of their participants increased their dosage without a physician’s instructions [ 26 ].…”

Section: Discussionsupporting

confidence: 86%

Propranolol Use Among Healthcare Students in Saudi Arabia

Aljahdali,

Badr,

Alotaibi

et al. 2023

Cureus

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Background: The learning performance and overall health of students might be impacted by excessive academic stress. While the right amount of stress can help improve learning and performance, too much stress can harm one’s mental and physical health as well as academic performance. This research aims to assess the prevalence and use of the beta-blocker propranolol among healthcare students in Saudi Arabia. Methods: A cross-sectional study was conducted among healthcare students at Umm Al-Qura University in Makkah, Saudi Arabia. The participants were sent an electronic questionnaire at random over three months, from June 10 to September 10, 2023. The data were analyzed using RStudio (version 4.2.2), and the categorized data were presented in frequencies and percentages. Fisher’s exact test was used to determine the factors associated with propranolol use. The results were reported as odds ratios (OR) and 95% confidence intervals (CI). A p-value of < 0.05 was considered statistically significant. Results: The study comprised 582 participants, of whom (51.7%, n=301) fell within the age range of 24 to 26 years, (63.1%, n=367) were male, and (59.3%, n=345) were enrolled in the College of Medicine and Surgery. The majority of respondents (73.7%, n=28) reported that educational materials such as medical books were their primary source of information regarding the impact of beta-blockers on anxiety. Among those who used propranolol, over two-thirds (68.4%, n=26) had taken it before the Objective Structured Clinical Examination (OSCE). About a quarter of the participants (26.1%, n=151) believed that propranolol was being misused by healthcare students, and (21.3%, n=123) believed that the drug could enhance academic performance. Conclusion: The primary motives for taking propranolol were to alleviate anxiety before OSCEs and enhance performance during presentations. The participants showed some understanding of the impact of propranolol. Nevertheless, it is imperative to impart knowledge to them about the potential hazards linked to the misuse of beta-blockers.

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Section: Discussionsupporting

confidence: 86%

Propranolol Use Among Healthcare Students in Saudi Arabia

Aljahdali,

Badr,

Alotaibi

et al. 2023

Cureus

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“…In spite of the abovementioned, the systematic review and meta-analysis conducted by Steenen et al concluded, that currently there is no sufficient evidence for the routine administration of propranolol in case of any anxiety disorders ( Steenen et al, 2016 ). Moreover, another meta-analysis also showed a lack of evidence of satisfactory quality to determine, whether or not to use propranolol in the treatment of stage fright ( Szeleszczuk and Frączkowski, 2022 ).…”

Section: Propranolol–an Old Drug With New Propertiesmentioning

confidence: 99%

Beta-blockers in cardiac arrhythmias–Clinical pharmacologist’s point of view

et al. 2023

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β-blockers is a vast group of antiarrhythmic drugs which differ in their pharmacokinetic and chemical properties. Some of them block β-adrenergic receptors selectively while the others work non-selectively. Consequently, they reduce the influence of the sympathetic nervous system on the heart, acting negatively inotropic, chronotropic, bathmotropic and dromotropic. Although they have been present in medicine since the beginning of the 1960s, they still play a crucial role in the treatment of cardiac arrhythmias. They are also first-line group of drugs used to control the ventricular rate in patients with the most common arrhythmia–atrial fibrillation. Previous reports indicate that infection with SARS-CoV-2 virus may constitute an additional risk factor for arrhythmia. Due to the aging of the population in developed countries and the increase in the number of patients with cardiac burden, the number of people suffering from cardiac arrhythmias will increase in the upcoming years. As a result the role of above-mentioned beta-blockers will remain significant. Particularly noteworthy is propranolol–the oldest beta adrenergic antagonist, which in recent years has found additional applications due to its unique properties. In this article, we reviewed the accessible literature and summarized the current guidelines on the use of beta-blockers in the treatment of cardiac arrhythmias.

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“…However, its use may be dependent on the type of disorder, showing promise for posttraumatic stress disorder but limited controversial evidence for long-term management of anxiety. 78,79…”

Section: Psychiatric Medicationsmentioning

confidence: 99%

Considerations in the Treatment of Depression and Anxiety in Women with PCOS

Alur-Gupta,

Dokras

2023

Semin Reprod Med

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Women with polycystic ovary syndrome (PCOS) are known to be at a greater risk of depression and anxiety. What is less clear is whether existing treatments for PCOS are effective in managing this increased risk and what the optimal approach to treatment is. In this review, currently available interventions are explored including lifestyle modifications, oral contraceptives, insulin sensitizing agents, psychosocial interventions and psychiatric medications. While data are often conflicting, lifestyle interventions, and cognitive behavioral therapy (CBT) appear most promising in reducing depression and anxiety symptoms in this population. There is an urgent need for large prospective studies to fill gaps in the literature.

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Propranolol versus Other Selected Drugs in the Treatment of Various Types of Anxiety or Stress, with Particular Reference to Stage Fright and Post-Traumatic Stress Disorder

Cited by 16 publications

References 186 publications

Propranolol Use Among Healthcare Students in Saudi Arabia

Propranolol Use Among Healthcare Students in Saudi Arabia

Beta-blockers in cardiac arrhythmias–Clinical pharmacologist’s point of view

Considerations in the Treatment of Depression and Anxiety in Women with PCOS

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