Considerations in the Treatment of Depression and Anxiety in Women with PCOS

Abstract

Women with polycystic ovary syndrome (PCOS) are known to be at a greater risk of depression and anxiety. What is less clear is whether existing treatments for PCOS are effective in managing this increased risk and what the optimal approach to treatment is. In this review, currently available interventions are explored including lifestyle modifications, oral contraceptives, insulin sensitizing agents, psychosocial interventions and psychiatric medications. While data are often conflicting, lifestyle interventions, and cognitive behavioral therapy (CBT) appear most promising in reducing depression and anxiety symptoms in this population. There is an urgent need for large prospective studies to fill gaps in the literature.

Utility of Serum Anti-Müllerian Hormone Measurement as Part of Polycystic Ovary Syndrome Diagnosis

“… 3 Moreover, depressive and anxiety symptoms are four to five times more prevalent and long lasting in women with PCOS, accompanied by additional psychological characteristics, including disordered eating and body image, conditions that all cause significant reduction in quality of life. 4 5 PCOS also increases pregnancy-related risks, including miscarriages, gestational diabetes, pregnancy-induced hypertension, preeclampsia, and premature delivery. 1 6 Given the high risk for several comorbidities, women with PCOS and young individuals with or at risk of PCOS should be identified from the population early on to enable early prevention and support, including during pregnancy.…”