Propoxyphene (Darvon) hepatotoxicity

Klein, Neil C.; Magida, Melville G.

doi:10.1007/bf02235094

Cited by 18 publications

(2 citation statements)

References 7 publications

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“…Also, different morphological damages were observed in the liver biopsy of the narcotic addicts. 35 – 37 Unlike these findings, some investigations have not reported considerable effects of MET use on liver. In this regard, Hosseini et al examined the effect of MET on the hepatic enzymes of rats.…”

Section: Discussionmentioning

confidence: 88%

“…Other studies have also reported hepatic damages and histopathological changes following narcotic use in animals and humans. 35 , 61 – 63 The increase in serum transaminase levels and reduction in hepatic glutathione levels have been observed in a large number of the studies that have dealt with the histopathological effects of narcotics. 59 Glutathione is a peptide involved in important cell functions such as inactivation of the electrophiles produced during oxidative metabolism.…”

Section: Discussionmentioning

confidence: 99%

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Histopathological study of liver tissue due to methadone consumption and its effect on liver enzymes and inflammatory indices in rat

Amraei¹,

Mohamadpour²,

Ahmadi³

et al. 2018

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BackgroundMethadone (MET)-based treatment is currently one of the best known approaches in the treatment of opioid dependence. It is claimed that MET use exerts adverse effects on the performance of some organs, especially liver. Thus, the present study aims to investigate MET effects on the hepatic tissue as well as its effect on the hepatic enzyme levels and inflammatory markers in rats.Materials and methodsTwenty-eight mature male Wistar rats underwent an 8-week treatment in four equal groups including the control group (an ordinary daily dietary regime) as well as the experimental groups 1, 2, and 3 (an ordinary daily dietary regime and gavage-fed on MET syrup for 5, 20, and 40 mg/kg body weight per day). Blood samples were collected from all rats in the beginning and end of the study to measure their hepatic enzyme levels and inflammatory markers. In the end, their livers were subjected to histological examinations.ResultsThe mean serum levels of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) increased considerably across all the three groups that had received various dosages of MET (5, 20, and 40 mg/kg) in the end of the study as compared to the beginning of the study (P<0.001). It was also found that the inflammatory indicators (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein) rose significantly in the groups that had received various dosages of MET in contrast to the control group (P<0.01, P<0.001, and P<0.001, respectively). The histopathological images of the liver cross-sections revealed dosage-dependent tissue changes in the groups that had received various dosages of MET.ConclusionThe present study tried to prove the adverse effects of MET in the development of liver damage. Since MET-based treatment is frequently prescribed by physicians for curing the addiction to narcotics, better strategies are required for its correct usage.

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Section: Discussionmentioning

confidence: 88%