Proposed model for a Romanian register of chronic diseases in children

Gabor-Harosa, Florina Maria; Stan, Ovidiu; Daina, L.; Mocean, Floarea

doi:10.1016/j.cmpb.2016.01.022

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…The present study confirmed that lower adiponectin levels are negatively associated with the presence of obesity and metabolic syndrome, a finding reported by previous studies (25). Adiponectin was associated with the presence of all the components of metabolic syndrome: abdominal obesity, hypertriglyceridemia, low HDL-cholesterol, high blood pressure and high glycaemia.…”

Section: Discussionsupporting

confidence: 93%

“…Adiponectin was associated with the presence of all the components of metabolic syndrome: abdominal obesity, hypertriglyceridemia, low HDL-cholesterol, high blood pressure and high glycaemia. Studies report that adiponectin levels are lower with increasing number of metabolic syndrome components (25). A study performed on a large population including 2,471 men and 3,463 women of Korean origin confirmed that adiponectin levels are associated with metabolic syndrome phenotype and all its components (26); similarly to the present study, all these individuals were persons not suffering of diabetes mellitus.…”

Section: Discussionsupporting

confidence: 88%

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Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

et al. 2020

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Metabolic syndrome is associated with increased risk of cardiovascular disease. This study investigated the correlation between adipocyte and inflammation biomarkers, and metabolic syndrome and its components. The study included 80 patients with normal body-mass index and 80 obese patients. The groups were assessed for serum values of adiponectin, leptin and highly sensitive C reactive protein (hsCRP), the homeostatic model assessment of insulin resistance (HOMA-IR), as well as the influence of these biochemical markers on the prevalence of metabolic syndrome and its components. Leptin, HOMA-IR and hsCRP had statistically significant (P<0.01) higher values in the group of obese subjects, while adiponectin had statistically significant (P<0.01) lower values. The prevalence of metabolic syndrome was 35% in the obese group and 5% in the normal weight group. Adiponectin and HOMA-IR were the variables significantly associated with metabolic syndrome (P<0.01), adiponectin/HOMA-IR ratio and leptin/adiponectin ratio were also associated with metabolic syndrome (P<0.01). No relationship was found between metabolic syndrome and hsCRP. Adiponectin and adiponectin/HOMA-IR were associated with all the components of metabolic syndrome and they can be useful to identify patients with high risk of diabetes mellitus and cardiovascular disease.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

et al. 2020

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“…Lack of adiponectin, another group of adipokines, is linked to vascular endothelial damage and insulin resistance, with a major risk of atherosclerotic plaque formation, playing a major role as anti-inflammatory hormone [ 101 , 102 ]. Lower adiponectin levels are negatively associated with the risk of obesity and metabolic syndrome [ 103 , 104 ]. In DKD patients, adiponectin showed a renoprotective function, translated in a reduction of albuminuria, glomerular hypertrophy, foot process effacement, regulation of mammalian target of rapamycin (mTOR) pathway, kidney inflammation mediators and modulates angiotensin II effects at renal tubular level [ 105 , 106 ].…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

The Aggressive Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes: Pathogenetic Mechanisms and Potential Therapies

et al. 2021

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Youth-onset Type 2 Diabetes Mellitus (T2DM) represents a major burden worldwide. In the last decades, the prevalence of T2DM became higher than that of Type 1 Diabetes Mellitus (T1DM), helped by the increasing rate of childhood obesity. The highest prevalence rates of youth-onset T2DM are recorded in China (520 cases/100,000) and in the United States (212 cases/100,000), and the numbers are still increasing. T2DM young people present a strong hereditary component, often unmasked by social and environmental risk factors. These patients are affected by multiple coexisting risk factors, including obesity, hyperglycemia, dyslipidemia, insulin resistance, hypertension, and inflammation. Juvenile T2DM nephropathy occurs earlier in life compared to T1DM-related nephropathy in children or T2DM-related nephropathy in adult. Diabetic kidney disease (DKD) is T2DM major long term microvascular complication. This review summarizes the main mechanisms involved in the pathogenesis of the DKD in young population and the recent evolution of treatment, in order to reduce the risk of DKD progression.

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“…goes first and foremost to the patient and their profession and only later to the employer. A motivated and adequately prepared workforce is a basic element for improving the performance of the health system [22,23]. The main negative factors influencing the medical staff in the Romanian medical organizations, mainly in the public hospitals are staff shortages (blocking of posts, staffing norms that are inadequate to current needs, migration of doctors and nurses); inadequate pay (low wages compared to the countries of the European Union, fixed status-on the same job, the same salary-without taking into account individual competence and performance); infrastructure; obsolete medical equipment; inefficient computer system; and poor communication.…”

Section: Introductionmentioning

confidence: 99%

Sustainable Management, Instable Legislation Regarding Wages, and Employee Satisfaction/Motivation in Two Romanian Hospitals

et al. 2020

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The aim of our study is to evaluate the employees’ level of satisfaction/motivation in two Romanian public hospitals in the context of numerous changes of the legislation concerning the level of payment of the employees working in the healthcare system, and to reveal the characteristics of a proper, sustainable management in this type of public healthcare unit. During 2015–2018, 4945 questionnaires were distributed to the staff of both hospitals, processed, and analyzed. In the Clinical County Emergency Hospital of Oradea, the analysis of the questionnaires showed a decrease in motivation (from 94.63% in 2017 to 79.14% in 2018). In the Timisoara County Clinical Emergency Hospital, for all the categories tested, there was a slight increase of the motivation. All the professional categories showed a degree of satisfaction with ascending evolution. Motivations of a different kind than the financial one, reinforced by the hospital’s management in recent years, have led to a general degree of employee satisfaction, 96.95% of them being satisfied that they work in the hospital. In the current unstable legislative context, financial motivation cannot be influenced by the management of public hospitals; therefore, the most appropriate measures that are needed must be geared towards increasing non-financial motivation.

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Proposed model for a Romanian register of chronic diseases in children

Cited by 10 publications

References 12 publications

Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

The Aggressive Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes: Pathogenetic Mechanisms and Potential Therapies

Sustainable Management, Instable Legislation Regarding Wages, and Employee Satisfaction/Motivation in Two Romanian Hospitals

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