Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

Zaha, Dana Carmen; Vesa, Cosmin Mihai; Uivaroșan, Diana; Bratu, Ovidiu Gabriel; Frățilă, Ovidiu; Ţiţ, Delia Mirela; Pantiş, Carmen; Bungău, Simona

doi:10.3892/etm.2020.8663

Cited by 24 publications

(28 citation statements)

References 38 publications

(31 reference statements)

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“…This study highlights a correlation between light physical activity, inversely proportional to the increase in this parameter. The statistically significant result in DTSG is also consistent with that obtained in other studies 16 .…”

Section: Discussionsupporting

confidence: 92%

The influence of dietary interventions on paraclinical parameters in patients with metabolic syndrome

Ghitea

Aron

Lazăr

et al. 2020

Arch Balk Med Union

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Section: Discussionsupporting

confidence: 92%

The influence of dietary interventions on paraclinical parameters in patients with metabolic syndrome

Ghitea

Aron

Lazăr

et al. 2020

Arch Balk Med Union

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“…There is intensive research related to the differentiation and role of white adipocytes [ 8 ], capable of storing and releasing lipids as well as releasing hormones (adipokines), and brown adipocytes capable of burning off energies [ 9 , 10 ]. Forkhead Box O1 (FoxO1), a participant of the FoxO family of transcription factors, plays a significant role in both the adipocyte forms.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Genetic Conception of Obesity via the Dual Role of FoxO

Behl

Kaur

Sehgal

et al. 2021

IJMS

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Obesity or overweight are not superficial problems, constituting a pressing issue. The obesity index has almost tripled since 1975, which is an alarming state. Most of the individuals are currently becoming overweight or have inappropriate body mass index (BMI) conditions. Obesity is characterized by increased fat accumulation and thus poses a higher health risk. There is increased size and volume of fat cells in the body, which usually accounts for obesity. Many investigations have been carried out in this area, such as behavioral improvements, dietary changes, chemical involvements, etc., but presently no such goals are established to manage these health concerns. Based on previous literature reports and our interpretation, the current review indicates the involvement of various transcriptional and transporter functions in modifying the above-mentioned health conditions. Various transcriptional factors such as Forkhead box O1 (FoxO1) impart a significant effect on the physiology and pathology of metabolic dysfunction such as obesity. FoxO1 plays a dual role whether in the progression or suppression of metabolic processes depending on its targets. Thus, in the current study, will be discussed the dual role of FoxO1 in metabolic conditions (such as obesity), also summarizing the role of various other transcriptional factors involved in obesity.

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“…Obesity is a major risk factor for diabetes, cardiovascular diseases, obstructive sleep apnea, non-alcoholic fatty liver disease, osteoarthritis, social stigmatization, and even cancer (1,3,4).…”

Section: Introductionmentioning

confidence: 99%

Manometric changes of the esophagus in morbidly obese patients

Popescu

Costache

Costache³

et al. 2021

Exp Ther Med

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This prospective study aimed to determine the manometric pattern and the prevalence of esophageal dysmotility in 79 morbidly obese patients selected for laparoscopic sleeve gastrectomy. After clinical evaluation and upper gastrointestinal endoscopy, high-resolution esophageal manometry was performed. The esophageal peristalsis, lower esophageal sphincter (LES) basal pressure, and LES relaxation were evaluated. Demographic data showed a predominance of females (55.70%) and both females and males were in the 5th decade of life. In addition, approximately 3/4 of the patients (78.48%) were from the urban zone. The mean body mass index of the patients was 46.40±6.0069 kg/m 2 , with a maximum of 61 kg/m 2 . The LES basal pressure was normal in 59.49% of the patients, with a mean value of 31.40±18.43 mmHg. LES basal hypertonia was observed in 26.58%, and LES hypotonia in 13.93% of patients; 46.84% (37 patients) had abnormal manometric findings: 24.05% (19 patients) had EGJ outflow obstruction, 12.66% (10 patients) ineffective esophageal motility, 3.8% (3 patients) distal esophageal spasm, 3.8% (3 patients) Jackhammer esophagus, 2 cases were suggestive for type 2 achalasia but in asymptomatic patients. Ineffective esophageal motility was not associated with diabetes mellitus type 2 or erosive esophagitis according to our data. Hiatal hernia (HH) was manometrically diagnosed in 23 patients (29.11%). Preoperative high-resolution esophageal manometry in obese patients demonstrated a high prevalence of motility disorders, but in asymptomatic patients, thus in the future, we require more studies and larger cohorts to better appreciate the clinical impact.

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Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

Cited by 24 publications

References 38 publications

The influence of dietary interventions on paraclinical parameters in patients with metabolic syndrome

The influence of dietary interventions on paraclinical parameters in patients with metabolic syndrome

Exploring the Genetic Conception of Obesity via the Dual Role of FoxO

Manometric changes of the esophagus in morbidly obese patients

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