Proposal for a multidimensional staging system for chronic obstructive pulmonary disease

Celli, Bartolomé R.; Calverley, P. M. A.; Rennard, Stephen I.; Wouters, Emiel; Agustí, A.; Anthonisen, Nicholas A.; MacNee, William; Jones, Paul; Pride, N. B.; Rodríguez-Roisin, Roberto; Rossi, Ana P.; Wanner, Adam

doi:10.1016/j.rmedu.2006.03.018

Cited by 19 publications

(22 citation statements)

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“…The negative correlation between CRP and the distance walked during the 6MWT found by us is similar to the findings of Pinto-Plata et al 27 and Torres et al 24 The fact that the correlation was stronger between CRP and the BODE index than a multidimensional index that does not take into account the 6MWT 10 seems to demonstrate that CRP is actually well associated with physical capacity. It was recently shown that physical activity reduces the risk of having high levels of circulating TNF-a and CRP.…”

Section: Discussionsupporting

confidence: 91%

“…This was accompanied by an inefficient adaptation of the muscle antioxidant systems to the changes generated by chronic exercise in these patients exhibiting systemic effects of the disease. A multidimensional index comprising postbronchodilator FEV 1 values (predicted %), the MMRC dypsnea scale and body mass index 10 showed a better correlation with lipid peroxidation (r ¼ 0.49; p ¼ 0.001; Table 3) than with its isolated variables, thereby confirming that the use of multidimensional indexes reflect more accurately the COPD systemic process. We also noted an association between lipid peroxidation and the BODE index (r ¼ 0.51; p ¼ 0.001; Figure 2), which adds the 6MWT in its calculation to the three other previously mentioned parameters.…”

Section: Discussionmentioning

confidence: 74%

“…10 Index values ranged from 1 to 7, with a mean of 2.9 þ 1.4 (Table 1). A positive correlation between this index and oxidative stress markers measured by TBARS (r ¼ 0.49; p ¼ 0.001) was observed ( Table 3).…”

Section: Assessment Of Oxidative Stress Markers and Inflammation Withmentioning

confidence: 99%

“…The multidimensional BODE index is a predictor of mortality in patients with COPD, assessing the pulmonary component as well as the systemic characteristics of the disease, evidence that COPD includes diverse aspects that should be analyzed when severity and prognosis are to be assessed. 9,10 It is possible that oxidative stress is better correlated with multisystemic indexes than to isolated parameters that evaluate COPD severity.…”

Section: Introductionmentioning

confidence: 99%

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Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

et al. 2011

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To evaluate the oxidative stress and the C-reactive protein (CRP) in chronic obstructive pulmonary disease (COPD) patients and their correlation between the severity of the disease according to GOLD criteria and multidimensional indexes such as BODE index. A blood sample was collected for thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase, glutathione (GSH), homocysteine (HCY) and CRP analysis from 45 stable COPD patients. Lung function, body nutritional status, dyspnea and 6-min walk test (6MWT) were evaluated. Patients with GOLD stage IV presented a higher value for the TBARS than stage I patients (4.47 þ 1.58 versus 2.27 þ 1.04 nmol/mL, p < 0.05). CRP was higher for GOLD IV (2.46 þ 3.68 mg/dL) than other stages (GOLD I :

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 74%

Section: Assessment Of Oxidative Stress Markers and Inflammation Withmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

et al. 2011

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“…This disease has complex effects on other aspects of respiratory function and, in most patients, is associated with important systemic changes [3].…”

Section: Bode Index and Pulmonary Rehabilitation In Chronic Respiratomentioning

confidence: 99%

BODE index and pulmonary rehabilitation in chronic respiratory failure

Biscione

Mugnaini

Pasqua³

et al. 2006

European Respiratory Journal

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One hundred years of chronic obstructive pulmonary disease (COPD)

Cazzola

Donner

Hanania

2007

Respiratory Medicine

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Chronic obstructive pulmonary disease (COPD) is an increasing health problem and one of the leading causes of morbidity and mortality worldwide, but knowledge about its pathogenesis has increased substantially in recent years. The disease results from interaction between individual risk factors (like enzymatic deficiencies) and environmental exposures to noxious agents, like cigarette smoking, occupational dusts, air pollution and infections in childhood. The main mechanisms that may contribute to airflow limitation in COPD are fixed narrowing of small airways, emphysema and luminal obstruction with mucus secretions. COPD is characterised by a chronic inflammatory process in the pulmonary tissue, with a pattern different from bronchial asthma, associated with extrapulmonary effects and is considered now a complex, systemic disease. Optimal therapeutic targeting of COPD depends on a clear understanding of the precise mechanisms of these complex processes and on early and correct evaluation of disease severity. A combination of pharmacological and non-pharmacological approaches is used to treat COPD. Bronchodilators are the mainstay of COPD treatment and can be combined with inhaled corticosteroids for greater efficacy and fewer side effects. The use of LTOT for hypoxemic patients has resulted in increased survival, and expanded drug therapy options have effectively improved dyspnoea and quality of life. Recent studies have documented the benefits of pulmonary rehabilitation. In addition, non-invasive mechanical ventilation offers new alternatives for patients with acute or chronic failure.

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Proposal for a multidimensional staging system for chronic obstructive pulmonary disease

Cited by 19 publications

References 0 publications

Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

BODE index and pulmonary rehabilitation in chronic respiratory failure

One hundred years of chronic obstructive pulmonary disease (COPD)

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