Propolis nanoparticles relieved the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia

Abdelmagid, Afaf D.; Said, Alshaimaa M.; Gawad, Eman A. Abdel; Shalaby, Sarah; Dawood, Mahmoud A.O.

doi:10.1007/s11356-021-17201-2

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…Meanwhile, the water was renewed with dechlorinated tap water in the control group. Glyphosate lethal concentration (LC50; 12 mg/L) was calculated earlier by Abdelmagid et al ( 2021 ), and fish was exposed to 1/20 of LC50 (0.6 mg/L) following Abdelmagid et al ( 2022 ). All fish have received the experimental diets twice daily at a feeding rate of 3% of the total body weight for four weeks under 12 h day:12 h night photoperiod regime.…”

Section: Methodsmentioning

confidence: 99%

“…In Nile tilapia, sublethal toxicity of glyphosate induced negative histopathological impacts and inflammation features in the kidney (Hassan et al 2022 ), gills (Jiraungkoorskul et al 2003 ), liver (Abdelmagid et al 2021 ), and spleen (Zheng et al 2021 ) tissues. Further, immunosuppression (Abdelmagid et al 2022 ), oxidative stress (Acar et al 2021 ), and pro-inflammation responses were seen in Nile tilapia exposed to glyphosate herbicide. Therefore, it can be hypothesized that using ginger or its nanoparticles could relieve the negative impacts of glyphosate toxicity in Nile tilapia.…”

Section: Introductionmentioning

confidence: 99%

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Glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia, but ginger showed a protection role

et al. 2022

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The water-borne herbicides are involved in the toxicity of aquatic animals resulting in impaired health status and low productivity. Dietary medicinal herbs present a practical solution to relieve the impacts of herbicides toxicity on the performances of aquatic animals. Herein, we investigated the toxicity of commercial glyphosate-induced oxidative stress, immunosuppression, liver and kidney dysfunction, and the protective role of ginger or ginger nanoparticles in Nile tilapia. Fish were allocated into four groups: the first group presented the control without glyphosate toxicity and ginger feeding, the second group intoxicated with glyphosate at 0.6 mg/L and fed ginger free diet, the third group intoxicated with glyphosate and fed ginger at 2.5 g/kg, and the fourth group intoxicated with glyphosate and fed ginger nanoparticles at 2.5 g/kg. Fish were kept under the experimental conditions for four weeks, and the samples of blood and tissues were collected after 2 and 4 weeks. Markedly, fish exposed to glyphosate showed the highest ALT and AST activities, glucose and cortisol levels, and malondialdehyde levels (MDA) in gills and tissues. While fish in the control and fish intoxicated with glyphosate and fed ginger nanoparticles had the lowest ALT and AST activities, glucose and cortisol levels, and MDA levels after 2 and 4 weeks (P < 0.05). Fish fed dietary ginger had lower ALT and AST activities, glucose and cortisol levels, and MDA levels than the glyphosate intoxicated group after 2 and 4 weeks (P < 0.05). Interestingly, fish-fed ginger nanoparticles showed lower urea and creatinine levels and higher total protein, albumin, and globulin than the glyphosate intoxicated group (P < 0.05) and similar to the control (P > 0.05). Further, fish intoxicated with glyphosate and fed ginger nanoparticles had the highest GSH, lysozyme activity, and immunoglobulin levels after 2 and 4 weeks (P < 0.05). In conclusion, ginger nanoparticles are superior to the standard ginger form in enhancing the antioxidative and immune responses of Nile tilapia exposed to glyphosate.

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Section: Methodsmentioning

confidence: 99%