Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats

Xue, Meilan; Liu, Ying; Xu, Hongwei; Zhou, Zhitong; Ma, Yan; Sun, Ting; Liu, Man; Zhang, Huaqi; Liang, Hui

doi:10.1016/j.biopha.2019.109393

Cited by 42 publications

(31 citation statements)

References 40 publications

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“…In general, polyphenol-rich propolis extracts were found to strengthen the intestinal barrier in rats by activating AMP-activated protein kinase and extracellular signal-regulated kinases (ERK) signaling [ 72 ]. Xue et al [ 73 ] reported that propolis supplementation to diabetic-induced rats modulated gut microbiota and improved intestinal epithelium tight and gap junctions.…”

Section: Discussionmentioning

confidence: 99%

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

et al. 2020

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Propolis (PR) is a resin product of bee colonies that has rich bioactive antioxidant and bactericidal compounds. Endotoxin, a byproduct of bacterial growth, is reported to cause progressive induction of endogenous oxidative stress and has negative impacts on individual health and wellbeing. Hereby, we investigated the ability of PR to alleviate the oxidative stress and immunosuppression imposed by avian pathogenic Escherichia coli using laying hen as a based model. In this study, PR was dietary supplemented to hens for 4 weeks at a concentration of 0.1%. At the beginning of the 4th week of the experiment, hens from control and PR treatment were injected with E. coli (O157:H7; 107 colonies/hen) or saline. The results showed significant (p < 0.05) negative impact of E. coli challenge on antioxidant status, immune response and productive performance. PR supplementation reduced (p < 0.05) inflammation markers levels (tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β)) and plasma corticosterone concentration. The antioxidant status was ameliorated with dietary PR supplementation to challenged hens, showing significant (p < 0.05) reduction in malondialdehyde (MDA) levels and increasing total antioxidant capacity (TAC) concentrations. Cell mediated, as well as, humeral immune response improved significantly (p < 0.05) with dietary PR verified by the enhancement of T- and B-lymphocyte proliferation and the positive respond to phytohemagglutinin (PHA). Leucocyte cells viability increased significantly and the apoptotic factor forkhead box O3 (Foxo3) was reduced with PR supplementation. The current study revealed that dietary PR supplementation can effectively be used as an organic feed additive to overcome the endogenous oxidative stress induced by endotoxins challenge.

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Section: Discussionmentioning

confidence: 99%

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

et al. 2020

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“…Estudos in vitro e com humanos apontam que a ingestão de compostos fenólicos pode inibir alguns grupos de bactérias enquanto estimula outros (PETERSON et al, 2018;XUE et al, 2019;ZHOU et al, 2020).…”

Section: Consumo Alimentar Dos Indivíduos Ao Longo Do Experimentounclassified

Caracterização de compostos bioativos de maracujá (>i<Passiflora tenuifila>/i<) e efeito do seu consumo sobre marcadores bioquímicos, microbiota intestinal em indivíduos eutróficos e obesos

Santos¹

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“…Accordingly, levels of fasting blood glucose and glycosylated hemoglobin significantly dropped while glucose tolerance and insulin sensitivity index remarkably increased. 59 It is well-known that glucose-metabolism dysregulation is a key contributor to skeletal muscle loss in diabetes. 26 The mechanism involved entails impairment of protein anabolism in muscle fibers and alteration of the structure of blood vessels resulting in less blood supply to skeletal muscle.…”

Section: Figure 1 Schematic Illustration Of the Contribution Of Gut mentioning

confidence: 99%

Targeting Gut Microbiome and the Recovery of Muscle Loss Associated with Cancer (Cachexia): An Overview of the Possible Effect of Bee Products

Amira Mohammed Ali,

Esraa Mohammed Ali,

Mostafa Elsayed Ahmed

et al. 2021

MLU

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Current research emphasizes the contribution of gut microbiome to numerous health conditions including cancer and skeletomuscular disorders. Cachexia is a debilitating condition of progressive loss of body tissues. It occurs in up to 80% of patients with tumors, and it impairs their functioning and quality of life and increases morbidity and premature death. Several randomized trials indicate that interventions, which target gut microbiome can correct and revert tissue loss in aged people. However, less is known about the effect of such strategies in cachectic muscle loss. This report briefly sheds the light on the role of gut-muscle axis in cachexia and demonstrates few examples on interventions addressing gut microbiome and their effect on cachectic muscle. It also speculates the literature for the skeletal muscle-promoting activity of bee products, particularly bee honey and propolis (which are quite handy), within the context of cachexia. Implications for future studies are discussed.

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Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats

Cited by 42 publications

References 40 publications

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

Modulating Laying Hens Productivity and Immune Performance in Response to Oxidative Stress Induced by E. coli Challenge Using Dietary Propolis Supplementation

Caracterização de compostos bioativos de maracujá (>i<Passiflora tenuifila>/i<) e efeito do seu consumo sobre marcadores bioquímicos, microbiota intestinal em indivíduos eutróficos e obesos

Targeting Gut Microbiome and the Recovery of Muscle Loss Associated with Cancer (Cachexia): An Overview of the Possible Effect of Bee Products

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