Caracterização de compostos bioativos de maracujá (>i<Passiflora tenuifila>/i<) e efeito do seu consumo sobre marcadores bioquímicos, microbiota intestinal em indivíduos eutróficos e obesos

Effects of passion fruit (>i<Passiflora tenuifila>/i< Killip) intake on eutrophic and obese subjects: Lipidomic approach.

“…The doctoral project conducted by reported that among the metabolites found in urine samples of the subjects enrolled in the clinical trial, six are directly correlated to the metabolism of flavan-3-ols, of which five are PVLs and PVAs and one is a glucuronidated metabolite of methyl-(epi)-catechin. Moreover, the flavone luteolin, present in P. tenuifila, and some of its metabolites were also identified in the urine samples (SANTOS, 2020a). What can be inferred from this analysis is that the phenolic compounds related to the intake of passion fruit were bioavailable in these subjects and could be related to the lipid modulation effects found in our studies.…”

“…This suggests that the obese contribute more to this separation, which could be due to 1) there being slightly more obese subjects in the study than eutrophics, or 2) obese being more responsive to the intervention. It has been argued that dietary interventions with functional foods or bioactive compounds and their food matrices could benefit those who present an altered metabolism, such as obese or insulin-resistant subjects (SANTOS et al, 2022;SANTOS, 2020a).…”

“…Lipidomic analyses have also been applied to dietary intervention studies in health and disease, providing insights into the complex relationship between host characteristics, barriers, and responsiveness to food components. Insulin-resistant subjects (n=25) who were administered orange juice (400 mL) for 15 consecutive days showed a decrease in a large variety of TAG that was then correlated with plasma VLDL, total TAG, and blood pressure (SANTOS et al, 2022). Also, a two-week-long period of orange juice intake (250 mL, twice a day) leads to an increase in short-chain acylcarnitines and a decrease in medium and long-chain acylcarnitines in healthy adult subjects (n=15, both sexes), demonstrating an effect on lipid metabolism (MOREIRA et al, 2018).…”

“…EMBRAPA-Cerrados, in their experimental camp (Brasilia, Brazil), produced the Passiflora tenuifila Killip fruits and they were granted to the study by Dr. Ana Maria Costa, EMBRAPA and Passitec network researcher, to produce the lyophilized passion fruit flour. The physicochemical characterization of the fresh fruit batches, in both edible green and ripe stages, resulted in 11.62g/100g (FW) of DF, of which circa 99% are insoluble fibers, and PAC content ranged from 267 to 383 mg/100g (FW) (SANTOS, 2020b;SANTOS et al, 2021).…”