Propolis Modifies Collagen Types I and III Accumulation in the Matrix of Burnt Tissue

Olczyk, Paweł; Wisowski, Grzegorz; Komosińska-Vassev, Katarzyna; Stojko, Jerzy; Klimek, Katarzyna; Olczyk, Monika; Koźma, Ewa M

doi:10.1155/2013/423809

Cited by 65 publications

(63 citation statements)

References 44 publications

(59 reference statements)

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“…The therapeutic efficacy of propolis was verified throughout quantitative and qualitative analyses of collagen types I and III expression and degradation in wounds matrix, indicating that propolis could induce a favourable biochemical environment leading to re‐epithelization. The biological activity of propolis on wound repair and tissue regeneration may be correlated to its antimicrobial, antiinflammatory and immunomodulatory properties (Olczyk et al ., ; Martinotti and Ranzato, ). Hozzein et al .…”

Section: Biological Propertiesmentioning

confidence: 97%

Biological Properties and Therapeutic Applications of Propolis

2016

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Propolis is a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen and wax. In this review, the biological properties of propolis and some therapeutic applications are discussed. The same biological activities have been investigated until today, using samples from different geographic regions. Thus, the study of the biological properties of a given sample should always be associated with its chemical composition and botanical source, representing a particular sample of a given geographic area, exploring its biological potential and the role of its constituents. Efforts have been carried out to explain propolis' mechanisms of action in vivo and in vitro, but the majority of propolis' targets and actions are still unclear. The number of formulations containing propolis and patents have increased, although propolis extracts have been used deliberately with different recommendations, not always mentioning the chemical composition, vegetal source and the methods of extraction. Clinical studies will help to obtain criterious recommendations in view of the expected outcomes. Further investigation should explore the effects of common compounds found in the samples from all over the world in an attempt to standardize the research on propolis and to obtain new drugs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Biological Propertiesmentioning

confidence: 97%

Biological Properties and Therapeutic Applications of Propolis

2016

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“…Therefore, recently much attention has been paid to antioxidative substances of natural origin. Much research concentrates on the salutogenic and medical properties of bee products, such as: propolis, royal jelly, pollen, and bee bread (Daleprane et al, 2012;Jastrzębska-Stojko, Stojko, Rzepecka-Stojko, Kabała-Dzik, & Stojko, 2013;Markiewicz-Ż ukowska et al, 2013;Olczyk et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Polyphenol content and antioxidant activity of bee pollen extracts from Poland

Rzepecka‐Stojko

Stojko

Kurek-Górecka³

et al. 2015

Journal of Apicultural Research

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Our study determined the effect of extraction method of bee pollen on the optimal antioxidant activity of the extract obtained. We determined the content of polyphenols and flavonoids as well as the antioxidant activity of the ethanol extract of pollen loads (EEP), the pepsin extract of pollen loads (PEP), and the pepsin-digested extract of pollen loads (EEPP). The total content of polyphenols was measured using Follin-Ciocalteau reagent. The flavonoid content was measured using aluminum chloride. Phenolic acids and flavonoids were identified and quantified by HPLC. The antioxidant activity was measured by 2,2-diphenyl-picrylhydrazyl radical scavenging activity assays and Trolox equivalents antioxidant capacity. Antioxidant activities were the highest in EEPP and associated with the total content of phenolic and flavonoid compounds. This study indicated that pepsin digestion conducted before ethanol extraction allowed us to obtain more bioactive compounds, as well as the highest antioxidant activity of extract.Contenido en polifenol y actividad antioxidante de extractos de polen de abeja procedentes de Polonia Nuestro estudio determinó el efecto del método de extracció n del polen de abeja sobre el ó ptimo de actividad antioxidante del extracto obtenido. Determinamos tanto el contenido de polifenoles y flavonoides como la actividad antioxidante del extracto de cargas de polen en etanol (EEP por sus siglas en inglés), el extracto de cargas de polen en pepsina (PEP por sus siglas en inglés) y el extracto de cargas de polen de pepsina digerida (EEPP por sus siglas en inglés). El contenido total de polifenoles se midió utilizando el reactivo de Follin-Ciocalteau. El contenido de flavonoides se midió utilizando cloruro de aluminio. Los ácidos fenó licos y los flavonoides se identificaron y cuantificaron por HPLC. La actividad antioxidante se midió por ensayos de búsqueda de actividad de radicales 2,2-difenil-picrilhidrazilo y capacidad antioxidante equivalente de Trolox. Las actividades antioxidantes en el EEPP fueron las más altas y se asociaron con el contenido total de fenoles y flavonoides. Este estudio indicó que la digestió n por pepsina llevada a cabo antes de la extracció n con etanol permitió obtener más compuestos bioactivos así como el extracto con mayor actividad antioxidante.

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“…Leishmania causes high inflammatory and propolis has antioxidant and anti-inflammatory properties that may lead to healing wounds such as cutaneous leishmaniasis (7,(13)(14)(15). Indeed, different activities of propolis including enhancing the expression of collagens Type I and III (16,17) and IFNγ (16), influencing the elimination or reduction of fibrosis development (17), decreasing the release of fibronectin (18), forming biocellulose membranes (10), stimulating natural killer cells, and influencing the release of nitric acid and tumor necrosis factors from macrophages (4) have been reported to help the tissue repair or heal cutaneous leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo

Tavakoli

Shaddel

Yakhchali

et al. 2020

Ann Mil Health Sci Res

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Background: Propolis is produced by honey bees from plants, buds, and exudates and as an antiseptic is used to treat several diseases, such as acne and wounds. Objectives: Due to some difficulty in the treatment of cutaneous leishmaniasis, the aim of this study was to evaluate the propolis extract function against Leishmania major.Methods: Different concentrations (9.375, 18.75, 37.5, 75, 150, and 300 µg/mL) of both Ethanolic Extract of Propolis (EEP) and the standard drug (Glucantime) were prepared for the in vitro model, and then applied to the fixed number of promastigotes. The promastigotes were counted after 24, 48, and 72-h treatment. Then, the viability of promastigotes was tested by MTT after 72 h of treatment. Twenty mice with cutaneous leishmaniasis were divided into four groups for in vivo model, including a positive group (treatment with Glucantime), a negative group (without treatment), and two experimental groups (treatment with EEP 1% and 4%). The sizes of the ulcers were measured at the beginning of the experiment and weekly for four weeks. Results: The in vitro model indicated that both EEP and Glucantime reduced the number of promastigotes and the difference between EEP and Glucantime was not significant at concentrations 37.5, 75, 150, and 300 µg/mL. The in vivo model demonstrated that EEP 4% and Glucantime were similar and decreased the size of ulcers more significantly than the negative control and EEP 1% (P < 0.05). Conclusions: Propolis as an herbal drug had antileishmanial activity against Leishmania major in vitro and in vivo. We suggest using it for complementary treatment.

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Propolis Modifies Collagen Types I and III Accumulation in the Matrix of Burnt Tissue

Cited by 65 publications

References 44 publications

Biological Properties and Therapeutic Applications of Propolis

Biological Properties and Therapeutic Applications of Propolis

Polyphenol content and antioxidant activity of bee pollen extracts from Poland

Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo

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