Biological Properties and Therapeutic Applications of Propolis

Sforcin, José Maurício

doi:10.1002/ptr.5605

Cited by 395 publications

(371 citation statements)

References 159 publications

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“…1,24,25 Also in our study, we used total propolis extract instead of isolating one of the flavonoids included in the propolis. Biological activity of propolis mainly ascribed to its content of flavonoids and various phenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Mısır¹,

Aliyazıcıoğlu²,

Demir³

et al. 2018

IJPER

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Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Total phenolic and flavonoid contents, reducing power, radical scavenging capacity, and iron chelating activity of EEP were determined using spectrophotometric methods. Intracellular ROS levels were determined by spectrofluorometric analysis with CM-H 2 DCFDA. Results: Our results indicated that antioxidant activity was correlated with the higher total phenolic and flavonoid contents of EEP. The generated ROS levels were significantly decreased by EEP compared to only t-BHP group. Conclusion: Ethanolic propolis extract may be evaluated as a potency antioxidant resource and/or a novel natural agent in food and drug industries.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Mısır¹,

Aliyazıcıoğlu²,

Demir³

et al. 2018

IJPER

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“…Afterwards, 20 mL of a 1 M Na 2 SO 3 solution were added under stirring. Just after the mixing of Fe 3+ and SO 3 2− , the color of the solution altered from light yellow to red, indicating the formation of a complex ion. Meanwhile, an ammonia solution was prepared by the dilution of 50.8 mL of concentrated ammonia to a final volume of 800 mL.…”

Section: Methods #2mentioning

confidence: 99%

“…The so synthesized super paramagnetic Fe 3 O 4 nanocrystals are capped with dehydroascorbic acid (the oxidized form of ascorbic acid). In a typical experiment, 0.33 g of FeCl 3 were dissolved in 25 mL of H 2 O, under continuous stirring. Then, 10 mL of 0.6 M Na 2 CO 3 (0.6 M) were added, drop by drop and, 10 min later, 0.12 g ascorbic acid were also added.…”

Section: Methods #3mentioning

confidence: 99%

“…Polyphenols, terpenoids including steroids, naphthalene and stilbene derivatives, and fatty acids are some examples of organic compounds that can be found in propolis [1,2]. Different biological properties have been attributed to propolis, such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, spasmolytic, anaesthetic, anticancer, and immunomodulatory effects [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Biohybrid Magnetite Nanoparticles and Moroccan Propolis on Adherence of Methicillin Resistant Strains of Staphylococcus aureus

et al. 2016

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Biofilm bacteria are more resistant to antibiotics than planktonic cells. Propolis possesses antimicrobial activity. Generally, nanoparticles containing heavy metals possess antimicrobial and antibiofilm properties. In this study, the ability of adherence of Methicillin Resistant Strains of Staphylococcus aureus (MRSA) to catheters treated with magnetite nanoparticles (MNPs), produced by three methods and functionalized with oleic acid and a hydro-alcoholic extract of propolis from Morocco, was evaluated. The chemical composition of propolis was established by gas chromatography mass spectrometry (GC-MS), and the fabricated nanostructures characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Mossbauer spectroscopy and Fourrier transform infrared spectroscopy (FTIR). The capacity for impairing biofilm formation was dependent on the strain, as well as on the mode of production of MNPs. The co-precipitation method of MNPs fabrication using Fe 3+ and Na 2 SO 3 solution and functionalized with oleic acid and propolis was the most effective in the impairment of adherence of all MRSA strains to catheters (p < 0.001). The adherence of the strain MRSA16 was also significantly lower (p < 0.001) when the catheters were treated with the hybrid MNPs with oleic acid produced by a hydrothermal method. The anti-MRSA observed can be attributed to the presence of benzyl caffeate, pinocembrin, galangin, and isocupressic acid in propolis extract, along with MNPs. However, for MRSA16, the impairment of its adherence on catheters may only be attributed to the hybrid MNPs with oleic acid, since very small amount, if any at all of propolis compounds were added to the MNPs.

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“…Propolis is a water-insoluble resinous 1 mixture of bees saliva and vegetable resinous substance with a wide range of important biological properties (antioxidant, anti-inflammatory, antitumoral, immunomodulating, antibacterial, antiviral, antibiofilm, antifungal, analgesic, anesthetic and antiparasitic) 2 .…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model

Melo

Alves²,

Silva³

et al. 2018

Acta Cir. Bras.

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Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model 1 Abstract Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E). Results: In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001). Conclusion: Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.

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Biological Properties and Therapeutic Applications of Propolis

Cited by 395 publications

References 159 publications

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Impact of Biohybrid Magnetite Nanoparticles and Moroccan Propolis on Adherence of Methicillin Resistant Strains of Staphylococcus aureus

Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model

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