Propolis extract as pulp capping material enhances odontoblast-like cell thickness and type 1 collagen expression (in vivo)

Widjiastuti, Ira; Subiyanto, Ari; Ningtyas, Evri Kusumah; Popyandra, Rendy; Kurniawan, Michael Golden; Retnaningsih, Fauziah Diajeng

doi:10.20473/j.djmkg.v53.i1.p1-5

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Pulpal perforation due to iatrogenic errors occurs in approximately 2-12% of teeth receiving endodontic treatment. 2,3 Inflammation that continues to be chronic can cause failure in the tissue and this can lead to pulp necrosis. 4 Neutrophils are the first immune cells that arrive to lesions 5 and will undergo apoptosis after 1-2 days.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

et al. 2020

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Background: One cause of pulpitis is mechanical trauma such as pulp perforation. The emergency treatment of pulpitis in a clinic uses eugenol. Eugenol in a high concentration causes cytotoxicity, which causes local necrosis and inhibits the recovery process, while in lower doses it can cause oral mucosal hypersensitivity. Due to these side effects, it is worth considering other biocompatible materials with minimal side effects, such as epigallocatechin-3-gallate (EGCG) which is found in green tea. As a polyphenol, EGCG has a radical scavenging ability, which has an effect on reducing the number of neutrophils. The application of EGCG is expected to reduce neutrophils on the second day after injury so the rehabilitation process is completed more quickly and ongoing inflammation and pulp necrosis is prevented. Purpose: To analyse the efficacy of topical hydrogel EGCG in reducing the number of neutrophils after 48 hours in the perforated dental pulp of Wistar rats. Method: 20 Wistar rats were divided equally into four groups, which were designated control (C) and treatment groups (T1, T2, T3). The upper first molar teeth of each rat were perforated and then T1, T2, and T3 were given 60 ppm, 90 ppm and 120 ppm hydrogel EGCG respectively. On the second day, the rats were sacrificed. HPA preparations were made to calculate the number of neutrophils in each group. Data was analysed using Kolmogorov–Smirnov, Levene’s, one-way ANOVA and Tukey HSD test (p<0.05). Results: There were significant differences between T2 and T3 compared with C and T1 (p<0.05), but no significant differences in the comparison of T1 with C and of T2 with T3 (p>0.05). Conclusion: 90 ppm hydrogel EGCG is effective in reducing the number of neutrophils in the perforated dental pulp of Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

et al. 2020

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Combination of 50% galam (Melaleuca cajuputi) leaf gel extract and tricalcium silicate cement as direct pulp capping materials: In vivo study

Nugroho,

Diana,

Rieuwpassa

et al. 2024

The 1st New Dental Research Exhibition and Meeting (New Dream) 2023

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Natural Vital Dental Pulp Therapy

Alrafee

2024

Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems

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Curiosity in pharmaceutical greenery has blossomed due to the expanded productiveness of incoming herbal extract medicine and the rising concern in natural materials to avoid the undesirable effects of traditional drugs. This comes in the same line with the need to keep up pulp liveliness and function of the normal pulp tissue, which is essential for reparative dentin formation. In the previous decade, fully grown adult teeth with pulp exposure had fewer favorable results, and endodontic treatment choice has succeeded over other therapies. Now, eradicating microorganisms from dentin pulp complex and promoting renewal has become the focus of attention. Different materials used in vital pulp therapy procedures help dentin-pulp complex protection; nevertheless, these materials have different side effects, leading to failure of the procedure after a period of time. This article throws light on natural products used in vital pulp therapy procedures that assist in achieving security across pulp-dentin organs with fewer side effects on pulp health over a period of time.

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Propolis extract as pulp capping material enhances odontoblast-like cell thickness and type 1 collagen expression (in vivo)

Cited by 3 publications

References 18 publications

Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

Efficacy of topical hydrogel Epigallocatechin-3-gallate against neutrophil cells in perforated dental pulp

Combination of 50% galam (Melaleuca cajuputi) leaf gel extract and tricalcium silicate cement as direct pulp capping materials: In vivo study

Natural Vital Dental Pulp Therapy

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