Propofol Restores Brain Microvascular Function Impaired by High Glucose <i>via</i>  the Decrease in Oxidative Stress

Nakahata, Katsutoshi; Kinoshita, Hiroyuki; Azma, Toshiharu; Matsuda, Naoyuki; Hama-Tomioka, Keiko; Haba, Masanori; Hatano, Yoshio

doi:10.1097/01.anes.0000299830.13203.60

Cited by 23 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Propofol also decrease cerebral edema and cell injury after period of ischemia. Nakahata et al [26] study concluded that hyperglycemia impairs on dilatation of cerebral arteriols and enough doses of propofol improve function of cerebral microvasculature due to decreasing level of superoxides in the brain.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients

et al. 2014

View full text Add to dashboard Cite

BackgroundAcute hyperglycemia in the perioperative period is associated with significantly increased complications. In few human studies the effects of propofol and inhalational anesthetic on the glucose metabolism were compared. In this study we evaluated the effect of propofol and isoflurane on blood glucose during abdominal hysterectomy in diabetic patients.MethodsAfter approval by the Ethical Committee and written informed consent, thirty 35 to 65 years old diabetic women underwent for elective abdominal hysterectomy under general anesthesia were studied in this randomized single blind clinical trial study. The plasma glucose was maintained at 100 to 180 mg/dL during the operation. Anesthesia protocol was similar in two groups except maintenance of anesthesia that was with infusion of propofol in the propofol group and with isoflurane in the isoflurane group. Blood glucose level and the rate of insulin intake during surgery compared between two groups.ResultsMean blood glucose before induction of anesthesia did not have significant difference between two groups, but 60 and 90 minutes after starting the operation blood glucose in the propofol group was significantly lower than isoflurane group. Also with using Repeated Measure test, two groups was significantly different according to blood glucose (P=0.045). Mean of administration of insulin during the surgery did not have significant difference between two groups by using repeated measure test and P=0.271. Also mean of bispectral index in different times during the surgery between two groups didn't have significant difference (P=0.35 repeated measure test).ConclusionBlood glucose increased during maintenance of anesthesia with isoflurane compared to propofol during the surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The protective action of drugs against oxidative stress (20) found that propofol lowered oxidative stress, especially in rat brain. In a study on rats similar to ours, Abdelmajeed (21) found that intravenous diazepam increased oxidative damage to the rat liver, kidney, and heart, which was accompanied by increased nitric oxide (NO) levels.…”

Section: Discussionmentioning

confidence: 99%

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

Türkan

Aydın

Sayal

et al. 2011

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

General anaesthetics are often used in patients who are under oxidative stress due to a critical illness or surgical trauma. Some anaesthetics may worsen oxidative stress and some may act as antioxidants. The aim of this study was to evaluate liver, brain, kidney, and lung tissue oxidative stress in rats exposed to desfl urane and sevofl urane and in unexposed rats. The animals were divided in three groups: control (received only air); sevofl urane (8 %), and desfl urane (4 %). After four hours of exposure, we evaluated the levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), Cu, and Zn. Exposure to either of the anaesthetics signifi cantly increased lung MDA levels compared to control (Mann-Whitney U test; P<0.05), probably because it is the tissue directly exposed to anaesthetic gases. Oxidative stress and antioxidant activity in other tissues varied between the desfl urane and sevofl urane groups. Our results suggest that anaesthesiologist should not only be aware of the oxidative or antioxidative potential of anaesthetics they use, but should also base their choices on organs which are the most affected by their oxidative action.

show abstract

“…In addition, propofol has been reported to prevent the accumulation of excitatory amino acids, such as glutamate, in order to produce central inhibition [18]. In addition, propofol is reported to have neuroprotective effects [14,15]. For all these reasons, we chose propofol as the anesthetic agent to induce sleep in the patients with refractory chronic primary insomnia.…”

Section: Discussionmentioning

confidence: 99%

“…Chemically, propofol is unrelated to barbiturates, and is considered as being a safe drug. Propofol is reported to have protective effects in several diseases of central nervous system [14,15]. Tung et al [16] recently reported that the recovery of sleep-deprived rats which were anesthetized with propofol was the same as rats which were not sleep-deprived, and suggested that sleep and anesthesia may share common control mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Propofol-Induced Sleep: Efficacy and Safety in Patients with Refractory Chronic Primary Insomnia

Jiang

et al. 2010

Cell Biochem Biophys

View full text Add to dashboard Cite

Insomnia, defined as difficulty in falling asleep and/or staying asleep, short sleep duration, or poor quality sleep, is a common sleep disorder affecting 30-40% of adult population. We have conducted a randomized, double-blind, placebo-controlled study to test if anesthesia is therapeutically beneficial in patients with refractory chronic primary insomnia. We have assessed the efficacy and safety of propofol-induced sleep in these patients. This study comprised of 103 patients with refractory chronic primary insomnia (including 59 non-pregnant, non-lactating women; 28-60 years) and the participants were randomized to receive either physiological saline (placebo) (n = 39) or 3.0 g/l propofol (n = 64) in a 2-h continuous intravenous infusion for five consecutive nights. The Leeds Sleep Evaluation Questionnaire was used for the subjective assessment of sleep, and polysomnography was used for the objective measurement of sleep architecture and patterns. The assessments were done prior to and at the end of the 5-day treatment and 6 months after treatment period. The adverse effects of the treatment were also recorded. A 2-h continuous intravenous infusion of 3.0 g/l propofol for five consecutive nights improved the subjective and objective assessments of sleep in 64 patients with refractory chronic primary insomnia. This improvement occurred immediately after the therapy and persisted for 6 months. No serious adverse events were noticed during the period of drug administration or 6 months after the treatment. Propofol therapy is an efficacious and safe choice for restoring normal sleep in patients with refractory chronic primary insomnia.

show abstract

Propofol Restores Brain Microvascular Function Impaired by High Glucose via the Decrease in Oxidative Stress

Cited by 23 publications

References 37 publications

The Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients

The Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

Propofol-Induced Sleep: Efficacy and Safety in Patients with Refractory Chronic Primary Insomnia

Contact Info

Product

Resources

About