Propofol–ketamine vs propofol–fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes^a

Abstract

Both propofol-ketamine and propofol-fentanyl combinations provided effective sedation and analgesia during dressing changes in pediatric burn patients. But propofol-ketamine combination was superior to propofol-fentanyl combination because of more restlessness in patients given propofol-fentanyl.

Comparison of Propofol and Ketamine versus Propofol and Fentanyl for Puerperal Sterilization, A Randomized Clinical Tria

“…Several investigators, in various studies which were done, found that the co administration of ketamine with propofol during induction prevented the adverse haemodynamic outcomes which were seen when propofol was used alone [5,6]. Several strategies, including IV administration of 0.5 mg/kg ketamine prior to propofol induction and infusion, have been shown to decrease adverse haemodynamic events which were associated with isolated use of propofol [5].…”

A Comparative Evaluation of Ketamine-Propofol Versus Fentanyl-Propofol in Total Intravenous Anaesthesia- A Double Blind Randomised Clinical Trial

“…Similar results were obtained from other studies. 5,9,10,15 CONCLUSION Following Conclusions are drawn from the Present Study- Both ketamine and fentanyl in propofol infusion for short surgical procedures are equally safe and efficacious.  Infusion of propofol-ketamine and propofol-fentanyl both provides stable haemodynamics and good recovery profile.…”

“…Similar results were obtained from other studies. 1,5,8,9,10,12,13 Vallejo M. C. et al 5 also observed no statistical significance in their study. Similar results were obtained from other studies.…”

“…5,8,9,10,11 There was a decrease in mean SBP (119.08 ± 4.10) and (114.62 ± 6.47) in PK and PF group respectively immediately after induction. Later (mean ± SD) SBP remained stable among both groups at 5, 10, 15, 20, 25 min.…”

Tratamento da dor em queimados

“…As an advantage, it maintains the airway refl exes, blood pressure, and heart rate by indirect release of norepinephrine. The occurrence of hallucinations, a signifi cant adverse effect, may be attenuated by concomitant administration of benzodiazepines or propofol 37,38 . In a meta-analysis of ketamine at low doses and postoperative consumption of opioids, the authors concluded that there is a reduction of up to one-third in total dose administered.…”