Propofol in acute porphyria

McNeill, M. J.; Parikh, R. K.

doi:10.1111/j.1365-2044.1989.tb11419.x

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…In one study, propofol was used to induce anaesthesia in a patient with AIP with apparent safety [24], whereas another case report indicated that urinary concentrations of porphyrin and PBG increased in a VP patient anaesthetized with propofol [25]. However, this patient had been exposed to several anaesthetics over a few days, including an infusion of propofol, and the changes in concentrations of porphyrin and PBG were unconvincing [26,27]. The patient did not experience acute symptoms.…”

Section: Discussionmentioning

confidence: 99%

Propofol as an I.V. Anaesthetic Induction Agent in Variegate Porphyria

Meissner

Harrison

Hift

1991

British Journal of Anaesthesia

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The choice of an i.v. anaesthetic induction poses problems for the anaesthetist confronted with a patient with one of the acute porphyrias. We undertook a prospective clinical trial in 13 variegate porphyric subjects using propofol as an anaesthetic induction agent. Urinary porphyrin precursors and porphyrins were measured before operation and 1-5 days after operation. Stool and plasma porphyrin concentrations were measured over the same period. Comparison of these data in the porphyric patients and in 21 control subjects over the trial period revealed no significant change in porphyrin or porphyrin precursor output after operation. Urinary porphyrin precursor concentrations did not exceed the limits established for variegate porphyric patients in remission, and there were no changes in the stool and plasma porphyrin profiles or any symptoms of an acute porphyric attack. We conclude that propofol did not appear to be porphyrinogenic when used for the induction of anaesthesia in 13 patients with variegate porphyria.

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Section: Discussionmentioning

confidence: 99%

Propofol as an I.V. Anaesthetic Induction Agent in Variegate Porphyria

Meissner

Harrison

Hift

1991

British Journal of Anaesthesia

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“…The introduction of newer agents, which reportedly can be administered to patients with AIP with greater safety, makes the policy of elective surgery avoidance open for debate. ', [5][6][7][8][9] We recently successfully performed augmentation mammaplasty in a 23-year-old patient with AIP using propofol (2,6-diisopropylphenol, Diprivan) as the anesthetic agent. We believe this case demonstrates the safety of propofol in the porphyric patient.…”

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confidence: 99%