Propofol Impairs Neurogenesis and Neurologic Recovery and Increases Mortality Rate in Adult Rats After Traumatic Brain Injury*

Thal, Serge C.; Timaru-Kast, Ralph; Wilde, Florian; Merk, Philipp; Johnson, Frederik; Frauenknecht, Katrin; Sebastiani, Anne; Sommer, Clemens; Staib-Lasarzik, Irina; Werner, Christian; Engelhard, Kristin

doi:10.1097/ccm.0b013e3182a639fd

Cited by 43 publications

(36 citation statements)

References 36 publications

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“…Anesthetic agents acting via GABA A receptors are frequently used in these patients’ anesthesia to induce and maintain general anesthesia. [30] Drexel and coworkers assessed the expression of GABA A receptor subunit mRNAs in rats 6 hours and 4 months post-TBI in the hippocampus and thalamus. [31] In the hippocampus the expression of α1-, α2-, α5-, β2-, β3- γ2- and δ- GABA A receptor subunit mRNAs were down-regulated 6 and 24 hours post-TBI.…”

Section: Expression Of Gabaa Receptors Is Modified By Inflammation Anmentioning

confidence: 99%

New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors

Antkowiak

Rudolph

2016

Current Opinion in Anaesthesiology

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Purpose of the review This review highlights novel insights into the role of GABAA receptors in mediating clinically relevant actions of anesthetic agents. Recent findings GABAA receptors in the hippocampus are located on glutamatergic pyramidal cells and GABAergic interneurons. Etomidate-induced inhibition of a synaptic correlate of learning and memory is caused by receptors on non-pyramidal neurons, likely on interneurons that incorporate α5-subunits. Selective enhancement of α2-subunit containing GABAA receptors in the spinal cord provides antihyperalgesia against inflammatory and neuropathic pain without causing sedation, motor impairment and tolerance development. Inflammation, traumatic brain injury and exposure to anesthetic agents modify the expression patterns of GABAA receptors in a subtype-specific manner. These modifications may persist for weeks. The neuroactive steroid alphaxalone causes fast-onset and short duration anesthesia in humans. Cardiovascular and respiratory side effects are less severe than with propofol. Summary Identification of the molecular and cellular substrates involved in anesthesia and insights into disease- and drug-induced alterations in the expression patterns of GABAA receptors in the central nervous system are emphasizing the need for individualized anesthesia care. Introducing neuroactive steroids into clinical anesthesia is expected to reduce cardiovascular and respiratory side effects.

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Section: Expression Of Gabaa Receptors Is Modified By Inflammation Anmentioning

confidence: 99%

New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors

Antkowiak

Rudolph

2016

Current Opinion in Anaesthesiology

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“…The positive relationship between neurogenesis and neurological function has long been demonstrated [30, 31]. It is demonstrated that olfactory stimulus induces neurogenesis in the reward circuit, including the amygdala, striatum, entorhinal cortex, and hippocampus [28].…”

Section: Discussionmentioning

confidence: 99%

Altered Long Noncoding RNA and Messenger RNA Expression in Experimental Intracerebral Hemorrhage - a Preliminary Study

Cui

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Functional recovery in the chronic phase is a difficult problem in intracerebral hemorrhage (ICH) treatment. Long noncoding RNAs (lncRNAs) are demonstrated to be involved in central nervous system (CNS) disorders. However, the roles of lncRNAs in post-ICH injury and repair are poorly understood, especially those that may be attributed to long-term neurological deficit. The present study depicted the lncRNA and messenger RNA (mRNA) profile by microarray at late stage after an experimental ICH. Methods: LncRNA and mRNA microarray was used to first identify differentially expressed genes. Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to determine bio-functions and signaling pathways, with which differentially expressed genes are most closely related. Quantitative real-time polymerase chain reaction (PCR) was used to validate the results of microarray. Finally, the lncRNA-mRNA co-expression network was constructed to find the interaction of genes. Results: A total of 625 differentially expressed lncRNAs and 826 expressed mRNAs were identified. Altered genes were enriched in mitochon-drial matrix, G-protein coupled receptor signaling pathway, and olfactory transduction, which may be associated with ICH-induced pathophysiologic changes in the long term. A co-expression network profile based on 5 validated differentially expressed lncRNAs and 205 interacted mRNAs was composed of 210 nodes and 298 connections. Conclusion: Mitochondrial matrix, reduced G-protein coupled receptor activity, and impaired olfactory transduction may be involved in the sequelae following ICH. Further, these dysregulated lncRNAs and mRNAs may be the promising therapeutic targets to overcome obstacles in functional recovery following ICH.

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“…As such, the goal of HBO treatment for acute CO poisoning is the prevention of long-term and potentially permanent neuropsychological dysfunction, in addition to the enhancement of short-term survival rates (7). Emerging evidence indicates the suppression of hippocampal neurogenesis as an important mechanism underlying cognitive impairment associated with traumatic brain injury (13,20,35); therefore, we sought to investigate the hypothesis that early HBO therapy may exert the beneficial effect on acute CO poisoning-induced delayed memory impairment via preservation of neurogenesis. Four lines of evidence derived from the current study support our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Alleviates Carbon Monoxide Poisoning–Induced Delayed Memory Impairment by Preserving Brain-Derived Neurotrophic Factor–Dependent Hippocampal Neurogenesis

Liu

Yang

et al. 2016

Critical Care Medicine

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Propofol Impairs Neurogenesis and Neurologic Recovery and Increases Mortality Rate in Adult Rats After Traumatic Brain Injury*

Cited by 43 publications

References 36 publications

New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors

New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors

Altered Long Noncoding RNA and Messenger RNA Expression in Experimental Intracerebral Hemorrhage - a Preliminary Study

Hyperbaric Oxygen Therapy Alleviates Carbon Monoxide Poisoning–Induced Delayed Memory Impairment by Preserving Brain-Derived Neurotrophic Factor–Dependent Hippocampal Neurogenesis

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