Propofol for Induction and Maintenance of Anaesthesia: Comparison Between Younger and Older Patients

Abstract

The propofol requirements for the induction and maintenance of anaesthesia were compared in groups of younger and older patients. Side effects, influence on the cardiovascular system and recovery times were compared between 20 unpremedicated ASA I-III, 25-40-yr-old patients and 20 65-80-yr-old patients all scheduled to undergo elective surgery. After induction with propofol, anaesthesia was maintained with a continuous infusion of the drug. Vecuronium and fentanyl were administered as required. In the young group propofol 2.2 mg kg-1 and in the elderly 1.7 mg kg-1 were needed for induction (P less than 0.05). The maintenance doses were 10.0 mg kg-1 h-1 and 8.6 mg kg-1 h-1, respectively (P less than 0.01). Side effects were more pronounced in the younger patients. Influences on the cardiovascular system were definite, but mild. The younger patients awoke sooner: 7.8 v. 14.3 min (P less than 0.01) after the discontinuation of the infusion of propofol.

Evaluation of efficacy of priming dose of propofol in reducing induction dose requirements in patients undergoing elective surgeries under general anaesthesia

“…8 In the study by Scheepstra et al no premedication was used. 9 Inj. midazolam was used in dose of 0.05 mg/kg in our study.…”

A hierarchical system of on-line advisory for monitoring and controlling the depth of anaesthesia using self-organizing fuzzy logic

“…One paper (Jenstrup et al, 1990) defines recovery time as the interval from extubation to the time when the patient can give his/her correct date of birth. Some papers (Scheepstra et al, 1989;Struys et al, 2001) use awaking time (i.e., time from end of infusion to the patient opening his/her eyes, having the orientation, giving the correct date of birth, or obeying a command) to define the recovery time. In this paper, we have taken the latter definition and calculate the recovery time from the end of administering anaesthetic drugs to the patient obeying a command.…”

Impact of patient age on propofol consumption during propofol-remifentanil anaesthesia

“…Scheepstra and colleagues [11] young patients aged 25-40 yr and 20 old patients aged 65-85 yr, both groups receiving a propofolfentanyl anaesthetic. The propofol maintenance doses were significantly different with 10.0 Ϯ 1.3 mg kg Ϫ1 h Ϫ1 for the younger and 8.6 Ϯ 1.1 mg kg Ϫ1 h Ϫ1 for the older patients.…”