Propofol decreases spike firing frequency with an increase in spike synchronization in the cerebral cortex

Kajiwara, Mie; Kato, Risako; Oi, Yoshiyuki; Kobayashi, Masayuki

doi:10.1016/j.jphs.2019.11.005

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…First, we classified neurons based on PC and FR values in 0% desflurane (i.e., wakefulness) using K-means clustering. This was different from previous studies in which neurons were classified by either PC or FR alone [4,[6][7][8]. Figure 1A illustrates the clustering into three groups of neurons; high PC-high FR (HPHF; n = 55), low PC-high FR (LPHF; n = 99), and low PC-low FR (LPLF; n = 97), which represent active choristers, active soloists, and inactive soloists, respectively.…”

Section: Pc and Fr Are Increasingly Associated In Anesthesiacontrasting

confidence: 73%

“…No study to-date has investigated the dose-dependent effect of anesthesia on FR and PC properties in the same animal in a systematic manner. Considering the substantial changes in neural network dynamics [8,9] and the disruption in conscious cognitive functions anesthetics cause, we asked if and how anesthesia may affect neurons depending on their PC and FR and how this may disrupt sensory processing. Such an investigation should provide a more precise understanding of the statedependence of different neuron groups with distinct PC and FR, their role in sensory information processing, and how anesthesia disturbs consciousness.…”

Section: Introductionmentioning

confidence: 99%

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Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling

et al. 2021

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Section: Pc and Fr Are Increasingly Associated In Anesthesiacontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling

et al. 2021

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Section: Pc and Fr Are Increasingly Associated In Anesthesiacontrasting

confidence: 92%

Differential effect of anesthesia on visual cortex neurons with diverse population coupling

Lee

Tanabe

Wang

et al. 2020

Preprint

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Introduction: Firing rate (FR) and population coupling (PC) are intrinsic properties of cortical neurons.Neurons with different FR and PC have diverse excitability to stimulation, tuning curve, and synaptic plasticity. Therefore, investigation of the effect of anesthesia on neurons with different FR and PC would be important to understand state-dependent information processing in neuronal circuits.Methods: To test how anesthesia affects neurons with diverse PC and FR, we measured single-unit activities in deep layers of primary visual cortex at three levels of anesthesia with desflurane and in wakefulness. Based on PC and FR in wakefulness, neurons were classified into three distinct groups: high PC-high FR (HPHF), low PC-high FR (LPHF), and low PC-low FR (LPLF) neurons. Results: Applying repeated light flashes as visual stimuli, HPHF neurons showed the strongest early response (FR at 20-150ms post-stimulus) among the three groups, whereas the response of LPHF neurons persisted longest (up to 440ms). Anesthesia profoundly altered PC and FR, and differently affected the three neuron groups: (i) PC and FR became strongly correlated suppressing population-independent spike activity; (ii) Pairwise correlation of spikes between neurons could be predicted by a PC-based raster model suggesting uniform neuron-to-neuron coupling; (iii) Contrary to evoked-potential studies under anesthesia, the flash-induced early response of HPHF neurons was attenuated, and their spike timing was split and delayed; (iv) Late response (FR at 200-400ms post-stimulus) was suppressed both in HPHF and LPHF neurons.Conclusions: Anesthetic-induced association between PC and FR suggests reduced information content in the neural circuit. Altered response of HPHF neurons to visual stimuli suggests that anesthesia interferes with conscious sensory processing in primary sensory cortex.

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“…This shift is thought to be due to an increase in cortical synchrony, appears with loss of consciousness, and reverses with recovery of consciousness ( Akeju et al., 2014a ; Civillico and Contreras, 2012 ; Dasilva et al., 2021 ; Harvey et al., 2012 ; Hudetz, 2002 ; Lee et al., 2020 ; Purdon et al., 2013 ). Other effects on cortical neurons common to several general anesthetics include burst suppression ( Akrawi et al., 1996 ; Clark and Rosner, 1973 ), fragmentation ( Erchova et al., 2002 ; Lewis et al., 2012 ; Vizuete et al., 2014 ), decreases in activity ( Bastos et al., 2021 ; Hudetz et al., 2009 ; Kajiwara et al., 2020 ; Redinbaugh et al., 2020 ), and increases in correlation with the average local activity ( Aasebø et al., 2017 ; Lee et al., 2021 ). In addition to these effects, both cortico-cortical and cortico-thalamic disconnections of the resting state network have also been observed using functional magnetic resonance imaging (fMRI) during states of unconsciousness ( Akeju et al., 2014b ; Mashour and Hudetz, 2018 ; Uhrig et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

Bharioke¹,

Munz²,

Brignall³

et al. 2022

Neuron

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Propofol decreases spike firing frequency with an increase in spike synchronization in the cerebral cortex

Cited by 4 publications

References 24 publications

Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling

Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling

Differential effect of anesthesia on visual cortex neurons with diverse population coupling

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

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