Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial

Yamaguchi, Ai; Koyanagi, Izumi; Inoue, Shigeaki; Kochiyama, Tsukasa; Fukuda, Masataka; Saito, Masafumi; Hayashida, Masakazu

doi:10.21037/jtd-21-878

Cited by 4 publications

(8 citation statements)

References 28 publications

(24 reference statements)

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“…Moreover, as inhalation anesthetics, ketamine and propofol can exert immunosuppressive effects. 43,44 In terms of administration, intravenous anesthetics might be countered by the ease of use and administration of FIGURE 2. Animal welfare evaluation in 4T1 tumor-bearing BALB/c mice.…”

Section: Discussionmentioning

confidence: 99%

“…For example, propofol was shown to have an antioxidative effect, 38 which can counteract antitumor therapies. Moreover, as inhalation anesthetics, ketamine and propofol can exert immunosuppressive effects 43,44 . In terms of administration, intravenous anesthetics might be countered by the ease of use and administration of inhalation anesthetics, which allow anesthesia to be delivered in a very precise manner without long recovery periods.…”

Section: Discussionmentioning

confidence: 99%

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Repeated Contrast-Enhanced Micro-CT Examinations Decrease Animal Welfare and Influence Tumor Physiology

et al. 2022

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ObjectivesComputed tomography (CT) imaging is considered relatively safe and is often used in preclinical research to study physiological processes. However, the sum of low-dose radiation, anesthesia, and animal handling might impact animal welfare and physiological parameters. This is particularly relevant for longitudinal studies with repeated CT examinations. Therefore, we investigated the influence of repeated native and contrast-enhanced (CE) CT on animal welfare and tumor physiology in regorafenib-treated and nontreated tumor-bearing mice.Material and MethodsMice bearing 4T1 breast cancer were divided into 5 groups: (1) no imaging, (2) isoflurane anesthesia only, (3) 4 mGy CT, (4) 50 mGy CT, and (5) CE-CT (iomeprol). In addition, half of each group was treated with the multikinase inhibitor regorafenib. Mice were imaged 3 times within 1 week under isoflurane anesthesia. Behavioral alterations were investigated by score sheet evaluation, rotarod test, heart rate measurements, and fecal corticosterone metabolite analysis. Tumor growth was measured daily with a caliper. Tumors were excised at the end of the experiment and histologically examined for blood vessel density, perfusion, and cell proliferation.ResultsAccording to the score sheet, animals showed a higher burden after anesthesia administration and in addition with CT imaging (P < 0.001). Motor coordination was not affected by native CT, but significantly decreased after CE-CT in combination with the tumor therapy (P < 0.001). Whereas tumor growth and blood vessel density were not influenced by anesthesia or imaging, CT-scanned animals had a higher tumor perfusion (P < 0.001) and a lower tumor cell proliferation (P < 0.001) for both radiation doses. The most significant difference was observed between the control and CE-CT groups.ConclusionRepeated (CE-) CT imaging of anesthetized animals can lead to an impairment of animal motor coordination and, thus, welfare. Furthermore, these standard CT protocols seem to be capable of inducing alterations in tumor physiology when applied repetitively. These potential effects of native and CE-CT should be carefully considered in preclinical oncological research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Repeated Contrast-Enhanced Micro-CT Examinations Decrease Animal Welfare and Influence Tumor Physiology

et al. 2022

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“…Research on the effect of propofol on the immune function of cancer patients by Ren et al showed that propofol significantly increases the expression of CD4+ T cells and effectively reduces the concentration of cortisol, confirming the role of propofol in improving immune function and reducing stress response [ 18 ]. Moreover, previous studies revealed that propofol inhibits the biological activity of cancer cells in intraoperative anesthesia for pancreatic cancer, gastric cancer, liver cancer, lymphoma, and cervical cancer [ 19 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

Robustness of Propofol and Sevoflurane on the Perioperative Immune Function of Patients Undergoing Laparoscopic Radical Nephrectomy

Wang

Cui

Kong

et al. 2022

Journal of Oncology

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Objective. This study aimed to evaluate the robustness of propofol combined with sevoflurane in patients undergoing laparoscopic radical nephrectomy and its influence on immune function during perioperative period. A total of 140 patients who underwent laparoscopic nephrectomy in the Department of Oncology of our hospital from January 2018 to January 2020 were divided into the control group and the study group by the random number table method, with 70 cases in each group, who were given sevoflurane anesthesia and sevoflurane combined with propofol anesthesia, respectively. The anesthesia effect and perioperative immune function of the two groups of patients were compared. No remarkable difference was observed in the extubation time, breathing recovery time, and awakening time between the two groups; the extubation coughing score and postextubation restlessness score of the study group were significantly lower than those of the control group; the postoperative renal function indexes of the two groups of patients were not considerably different; after treatment, the CD3+ (%), CD4+ (%), and CD4+/CD8+ of the two groups of patients decreased significantly, with a higher level in the study group. For patients undergoing laparoscopic radical nephrectomy, the combination of propofol and sevoflurane yields a promising outcome in enhancing the anesthesia results and improving the perioperative immune function.

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“…However, even in malignancy without preceding inflammation, cancer-induced inflammation, secretions of inflammatory factors, and immune cell infiltration are main characters in tumor initiation and advanced metastasis [ 118 ]. Anesthesia and analgesia may impact cellular immunity and inflammation during surgery, and thus affect cancer outcomes [ 119 , 120 , 121 , 122 , 123 , 124 , 125 ].…”

Section: Tumor Factors: Emt Hypoxia-inducible Factor-1α (Hif-1α) Matr...mentioning

confidence: 99%

“…Recently, Li et al reported that high systemic immune-inflammation index levels were regarded as negative with regard to PC overall survival and cancer-specific survival [ 133 ]. Yamaguchi et al demonstrated that propofol reduced the number of CD8 + T cells, whereas sevoflurane augmented the percentage of regulatory T cells in lung-cancer surgery patients [ 121 ]. Sevoflurane was revealed to devastate multiple pulmonary functions by releasing a series of inflammatory secretions in lung cancer patients undergoing perioperative one-lung ventilation [ 134 ].…”

Section: Tumor Factors: Emt Hypoxia-inducible Factor-1α (Hif-1α) Matr...mentioning

confidence: 99%

Pancreatic Cancer and Microenvironments: Implications of Anesthesia

Lai

Kuo

Huang

et al. 2022

Cancers

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Pancreatic malignancy is a lethal neoplasm, as well as one of the leading causes of cancer-associated mortality, having a 5-year overall survival rate of less than 10%. The average life expectancy of patients with advanced pancreatic cancer does not exceed six months. Although surgical excision is a favorable modality for long-term survival of pancreatic neoplasm, metastasis is initially identified in nearly 80% of the patients by the time of diagnosis, making the development of therapeutic policy for pancreatic cancer extremely daunting. Emerging evidence shows that pancreatic neoplastic cells interact intimately with a complicated microenvironment that can foster drug resistance, metastasis, or relapse in pancreatic cancer. As a result, the necessity of gaining further insight should be focused on the pancreatic microenvironment contributing to cancer progression. Numerous evidence reveals that perioperative factors, including surgical manipulation and anesthetics (e.g., propofol, volatile anesthetics, local anesthetics, epidural anesthesia/analgesia, midazolam), analgesics (e.g., opioids, non-steroidal anti-inflammatory drugs, tramadol), and anesthetic adjuvants (such as ketamine and dexmedetomidine), might alter the tumor microenvironment and cancer progression by affecting perioperative inflammatory or immune responses during cancer surgery. Therefore, the anesthesiologist plays an important role in perioperative management and may affect surgical outcomes. However, the literature on the impact of anesthesia on the pancreatic cancer microenvironment and progression is limited. This review summarizes the current knowledge of the implications of anesthesia in the pancreatic microenvironment and provides future anesthetic strategies for improving pancreatic cancer survival rates.

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Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial

Cited by 4 publications

References 28 publications

Repeated Contrast-Enhanced Micro-CT Examinations Decrease Animal Welfare and Influence Tumor Physiology

Repeated Contrast-Enhanced Micro-CT Examinations Decrease Animal Welfare and Influence Tumor Physiology

Robustness of Propofol and Sevoflurane on the Perioperative Immune Function of Patients Undergoing Laparoscopic Radical Nephrectomy

Pancreatic Cancer and Microenvironments: Implications of Anesthesia

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