Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits

Endothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive rats

“…Examples include cardiac myopathies and peripheral arterial disease (Ferrari et al 1992), and improving the walking capacity in patients with peripheral vascular disease (Brevetti et al 1992). In animal models, l -carnitine and its derivatives have shown some bene® cial eOE ect such as protection against the development of vascular lesions in peripheral arterial insu ciency induced by intra-arterial injection of sodium laurate (Corsico et al 1993), the prevention of progression of atherosclerotic lesions (Spagnoli et al 1995) and age-dependent rise of plasma total cholesterol, triglycerides and uric acid of SHR (Rauchova! et al 1998) and the reduction in polyploid cells also in SHR (Mauriello et al 1996).…”

Propionyl-L-carnitine Reduces Proliferation and Potentiates Bax-related Apoptosis of Aortic Intimal Smooth Muscle Cells by Modulating Nuclear Factor-κB Activity

“…Small thoracic aortic rings were frozen in cooled isopentane for cryostatic sections. Remaining intimal and medial tissues were isolated as previously reported (30).…”

L-carnitine and taurine synergistically inhibit the proliferation and osteoblastic differentiation of vascular smooth muscle cells

“…LC can lower the lipoprotein serum levels of patients with type 2 diabetes mellitus [40] . Moreover, LC treatment (300 mg/kg body weight per day) for 7 and 14 d caused significant reduction of the tissue lipid peroxidation and marked improvement of the antioxidant status in atherosclerotic rats [41] , and the long-term oral administration of LC was associated with a decrease of plaque cell proliferation and the severity of aortic atherosclerotic lesions in a rabbit model [22] . Furthermore, previous data documented the fact that LC prevented the progression of atherosclerotic lesions in rabbits in association with a significant reduction of VSMC proliferation and plasma triglycerides [22][23][24][25] .…”

“…LC and TAU can exert therapeutic effects on atherosclerosis [14,[16][17][18][22][23][24][25] . Our present data indicate that LC and TAU synergistically inhibit the proliferation and β-GP-induced osteoblastic differentiation of VSMCs.…”

“…The conditions that appear to benefit from exogenous supplementation of LC include cardiovascular disease, anorexia, chronic fatigue, diphtheria, hypoglycemia, male infertility, muscular myopathies, Rett syndrome, dialysis, preterm infants and HIV-positive individuals [21] . Previous data documented that LC has a strong anti-atherogenic potential [22][23][24][25] .…”