Propionyl-L-Carnitine Improves Hemodynamics and Metabolic Markers of Cardiac Perfusion during Coronary Surgery in Diabetic Patients

Lango, Romuald; Smoleński, Ryszard T.; Rogowski, Jan; Siebert, Janusz; Wujtewicz, Maria; Słomińska, Ewa; Łysiak−Szydłowska, Wiesława; Yacoub, Magdi H.

doi:10.1007/s10557-005-3349-8

Cited by 25 publications

(17 citation statements)

References 23 publications

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“…Intravenous PLC administered prior to coronary artery bypass grafting significantly improved early post‐operative recovery in diabetic patients by increasing the cardiac index and reducing pulmonary artery pressure 101 . PLC also reduced transcardiac endothelin concentrations and accelerated myocardial hypoxanthine washout.…”

Section: Clinical Evidence Of the Therapeutic Value Of Plcmentioning

confidence: 98%

Pharmacological effects and clinical applications of propionyl-L-carnitine

et al. 2011

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Propionyl-L-carnitine (PLC) is a naturally occurring derivative of carnitine that plays an important role in the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. PLC, however, is not only a metabolic drug; it is also a potent antiradical agent and thus may protect tissues from oxidative damage. PLC has been demonstrated to exert a protective effect in different models of both cardiac and endothelial dysfunction, to prevent the progression of atherosclerosis, and, more recently, to improve some of the cardiometabolic alterations that frequently accompany insulin resistance. As a result, most of the clinical trials conducted in humans highlight PLC as a potential treatment option in cardiovascular diseases such as peripheral arterial disease, chronic heart failure, or stable angina, especially when type 2 diabetes mellitus or hyperglycemia (i.e., patients on hemodialysis) are also present. The aim of this review is to summarize the pharmacological effects and possible therapeutic applications of PLC, including the most recent findings to date.

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Section: Clinical Evidence Of the Therapeutic Value Of Plcmentioning

confidence: 98%

Pharmacological effects and clinical applications of propionyl-L-carnitine

et al. 2011

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“…As controls, extracts obtained from left ventricular biopsies of hearts with normal function taken from patients undergoing coronary artery bypass graft (CABG) were reanalyzed for creatine metabolite content. 15 The authors had full access to the data and take responsibility for its integrity. All authors have read and agree to the manuscript as written.…”

Section: Determination Of Creatine Metabolitesmentioning

confidence: 99%

Myocardial Expression of the Arginine:Glycine Amidinotransferase Gene Is Elevated in Heart Failure and Normalized After Recovery

et al. 2006

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Background-Combination therapy consisting of mechanical unloading using a left ventricular assist device (LVAD) and pharmacological intervention can promote recovery from end-stage heart failure, but the mechanism is unknown. Preliminary microarray analysis revealed a significant and unexpected decrease in myocardial arginine:glycine amidinotransferase (AGAT) gene expression during recovery in these patients. The aim of this study was to evaluate the expression and role of AGAT expression in heart failure and recovery. Methods and Results-We used quantitative real time (TaqMan) polymerase chain reaction to examine myocardial AGAT mRNA expression in implant and explant samples from recovering patients after combination therapy (nϭ12), end-stage heart failure (ESHF) samples from stable patients undergoing transplantation without LVAD support (nϭ10), and donor hearts with normal hemodynamic function (nϭ8). AGAT mRNA expression was significantly elevated in all heart failure patients relative to donors (4.3-fold [PϽ0.001] and 2.7-fold [PϽ0.005] in LVAD and ESHF relative to donors, respectively) and returned to normal levels after recovery. AGAT enzyme activity was detectable in both human and rat myocardia and was elevated in heart failure. Conclusions-Our data highlight local and potentially regulated expression of AGAT activity in the myocardium and suggest a specific response to heart failure involving elevated local creatine synthesis. These findings have implications both for the management of recovery patients undergoing combination therapy and for heart failure in general.

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“…L-carnitine consists of amino acids naturally produced in humans and lower animals. It plays a role as a carrier for translocation of long-chain fatty acids from the cytosol into the mitochondria for β-oxidation [6].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of Laser and L-carnitine against amiodarone-induced pulmonary toxicity in adult male rats

El-Nahrawy¹,

Zaher²,

Ali³

2017

Trop. J. Pharm Res

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Purpose: To compare the effects of laser and/or L-carnitine (LC) on amiodarone (AM)-induced lung toxicity in adult male rats. Methods: Lung toxicity was induced in 50 healthy male albino rats (150-180 g) by AM for 8 weeks. The rats were divided into 4 groups (7 per group): AM recovery, LC, laser, and laser + LC. After a 4-week exposure to laser and/or LC, key antioxidant enzymes, nitric oxide (NO), angiotensin II, cyclooxygenase-II (COX-II) and lipoxygenase (LOX) as well as oxidative stress and inflammation parameters were determined. Results: Administration of LC and/or laser exposure led to significant increases in reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and angiotensin II; and significant decreases in nitric oxide (NO) level and glutathione-S-transferase (GST) activity in the AM

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Propionyl-L-Carnitine Improves Hemodynamics and Metabolic Markers of Cardiac Perfusion during Coronary Surgery in Diabetic Patients

Cited by 25 publications

References 23 publications

Pharmacological effects and clinical applications of propionyl-L-carnitine

Pharmacological effects and clinical applications of propionyl-L-carnitine

Myocardial Expression of the Arginine:Glycine Amidinotransferase Gene Is Elevated in Heart Failure and Normalized After Recovery

Therapeutic effects of Laser and L-carnitine against amiodarone-induced pulmonary toxicity in adult male rats

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