Propionibacterium acnes catalase induces increased Th1 immune response in sarcoidosis patients

Yorozu, Pariko; Furukawa, Asuka; Uchida, Keiji; Akashi, Takumi; Kakegawa, Tomoya; Ogawa, Tomoya; Minami, Junko; Suzuki, Yoshimi; Awano, Nobuyasu; Furusawa, Haruhiko; Miyazaki, Yasunari; Inase, Naohiko; Eishi, Yoshinobu

doi:10.1016/j.resinv.2015.02.005

Cited by 27 publications

(20 citation statements)

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“…Catalase of P. acnes is known to be immunogenic and provokes Th1 immune response in sarcoidosis 12. We detected P. acnes antigen in the granulomas present in the epiretinal membrane excised from patients with uveitis associated with sarcoidosis.…”

Section: Discussionmentioning

confidence: 80%

Propionibacterium acnesas a possible pathogen of granuloma in patients with ocular sarcoidosis

et al. 2017

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Section: Discussionmentioning

confidence: 80%

Propionibacterium acnesas a possible pathogen of granuloma in patients with ocular sarcoidosis

et al. 2017

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“…Studies published in recent years have confirmed that P. acnes could be a possible infectious agent implicated in the pathogenesis of sarcoidosis [24, 56, 74–76]. However, some studies suggest that P. acnes is not specific for sarcoidosis because it is a normal inhabitant of peripheral lung tissue and mediastinal lymph nodes, apart from the skin [77].…”

Section: Discussionmentioning

confidence: 99%

Is there any association between Sarcoidosis and infectious agents?: a systematic review and meta-analysis

2016

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BackgroundDuring the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association.MethodsThis review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines. Four different databases (Medline, Scopus, Web of Science, and Cochrane Collaboration) were searched for all original articles published from 1980 to 2015. The present meta-analysis included case–control studies that reported the presence of microorganisms in samples of patients with sarcoidosis using culture methods or molecular biology techniques. We used a random effects or a fixed-effect model to calculate the odds ratio (OR) and 95% confidence intervals (CI). Sensitivity and subgroup analyses were performed in order to explore the heterogeneity among studies.ResultsFifty-eight studies qualified for the purpose of this analysis. The present meta-analysis, the first, to our knowledge, in evaluation of all infectious agents proposed to be associated with sarcoidosis and involving more than 6000 patients in several countries, suggests an etiological link between Propionibacterium acnes and sarcoidosis, with an OR of 18.80 (95% CI 12.62, 28.01). We also found a significant association between sarcoidosis and mycobacteria, with an OR of 6.8 (95% CI 3.73, 12.39). Borrelia (OR 4.82; 95% CI 0.98, 23.81), HHV-8 (OR 1.47; 95% CI 0.02, 110.06) as well as Rickettsia helvetica, Chlamydia pneumoniae, Epstein-barr virus and Retrovirus, although suggested by previous investigations, were not associated with sarcoidosis.ConclusionThis meta-analysis suggests that some infectious agents can be associated with sarcoidosis. What seems clear is that more than one infectious agent might be implicated in the pathogenesis of sarcoidosis; probably the patient’s geographical location might dictate which microorganisms are more involved. Future investigations and more clinical trials are need to bring these evidences to a more global level.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-016-0332-z) contains supplementary material, which is available to authorized users.

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“…A hypersensitive Th1 immune response to this commensal bacterium is thought to lead to granuloma formation in the susceptible subjects [24–26]. Based on the hypothesis that sarcoidosis is an allergic endogenous infection caused by P .…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients

et al. 2017

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BackgroundAlthough rare, cardiac sarcoidosis (CS) is potentially fatal. Early diagnosis and intervention are essential, but histopathologic diagnosis is limited. We aimed to detect Propionibacterium acnes, a commonly implicated etiologic agent of sarcoidosis, in myocardial tissues obtained from CS patients.Methods and resultsWe examined formalin-fixed paraffin-embedded myocardial tissues obtained by surgery or autopsy and endomyocardial biopsy from patients with CS (n = 26; CS-group), myocarditis (n = 15; M-group), or other cardiomyopathies (n = 39; CM-group) using immunohistochemistry (IHC) with a P. acnes-specific monoclonal antibody. We found granulomas in 16 (62%) CS-group samples. Massive (≥14 inflammatory cells) and minimal (<14 inflammatory cells) inflammatory foci, respectively, were detected in 16 (62%) and 11 (42%) of the CS-group samples, 10 (67%) and 10 (67%) of the M-group samples, and 1 (3%) and 18 (46%) of the CM-group samples. P. acnes-positive reactivity in granulomas, massive inflammatory foci, and minimal inflammatory foci were detected in 10 (63%), 10 (63%), and 8 (73%) of the CS-group samples, respectively, and in none of the M-group and CM-group samples.ConclusionsFrequent identification of P. acnes in sarcoid granulomas of originally aseptic myocardial tissues suggests that this indigenous bacterium causes granuloma in many CS patients. IHC detection of P. acnes in massive or minimal inflammatory foci of myocardial biopsy samples without granulomas may be useful for differentiating sarcoidosis from myocarditis or other cardiomyopathies.

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Propionibacterium acnes catalase induces increased Th1 immune response in sarcoidosis patients

Cited by 27 publications

References 16 publications

Propionibacterium acnesas a possible pathogen of granuloma in patients with ocular sarcoidosis

Propionibacterium acnesas a possible pathogen of granuloma in patients with ocular sarcoidosis

Is there any association between Sarcoidosis and infectious agents?: a systematic review and meta-analysis

Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients

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