Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp that these parameters do not necessarily correlate with invasively measured LV filling pressure in patients with hypertrophic cardiomyopathy, 2 severely reduced LV systolic function, 3 and heart failure with preserved ejection fraction (EF). 4
Editorial p 1104Reasons for inaccuracies with tissue Doppler-derived parameters could include angle dependency and myocardial tethering, levated left ventricular (LV) filling pressure results in shortness of breath, which is both a major symptom and a prognostic predictor for heart failure. Therefore, noninvasive estimation of LV filling pressure is considered a goal of routine echocardiography. Recent recommendations encourage using tissue Doppler-derived early-diastolic mitral annular velocity (e´) as a parameter of LV relaxation and the ratio of early-diastolic LV inflow velocity (E) to e´ (E/e´) to indicate LV filling pressure. Background: Speckle-tracking echocardiography (STE)-derived parameters may have better correlation with left ventricular (LV) relaxation and filling pressure than tissue Doppler-derived parameters. However, it has not been elucidated which parameter -strain or strain rate -and which direction of myocardial deformation -longitudinal or circumferential -is the most useful marker of LV relaxation and filling pressure.
HF patients with D-HCM had higher mortality risk than those with DCM. Effective management strategies are critically needed to be established for D-HCM.
A uniform global input function can suppress LV spillover into the image-derived blood input function, resulting in improved precision for MBF quantification with 3D (82)Rb PET.
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