Propionate supplementation did not increase whole body glucose turnover in growing lambs fed rye grass

Majdoub, Linda; Beylot, M.; Vermorel, M.; Ortigues-Marty, I.

doi:10.1051/rnd:2003026

Cited by 4 publications

(6 citation statements)

References 44 publications

(73 reference statements)

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“…3), the results obtained were situated at the intersection between those of adult ovines and those of growing bovines. Some logical discrepancy seemed to exist between those limited data since data for finishing growing lambs [45] were closer to those of adult ovines than those of younger growing lambs [22,69] which were closer to those of growing bovines. These results suggest that the effects of growth stage on glucose turnover rate are probably as important as the effect of animal species.…”

Section: Nutritional Status Of the Animal And Glucose Turnovermentioning

confidence: 86%

Whole body glucose turnover in growing and non-productive adult ruminants: meta-analysis and review

2003

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-The objectives of the present paper were to review and quantitatively determine the influence of the nutritional factors on whole body glucose turnover in growing and adult non-productive ruminants. A meta-analysis approach was used. The dietary grain: forage ratio significantly increased the slope of the relationship between glucose turnover and metabolisable energy intake. This effect was probably associated with the inclusion of maize rather than any other grain source in the diet. The analysis pointed out the possible differences in response between growing and adult non-productive animals, and suggested that the performance level of the animals (and their glucose requirements) could contribute to regulating whole body glucose turnover. This aspect would warrant further investigation.whole-body glucose turnover / meta-analysis / ovines / bovines

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Section: Nutritional Status Of the Animal And Glucose Turnovermentioning

confidence: 86%

Whole body glucose turnover in growing and non-productive adult ruminants: meta-analysis and review

2003

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“…Propionate can enter the Krebs cycle via succinyl-CoA for complete oxidation to CO 2 , or via malate before being metabolized in the extra-mitochondrial space into pyruvate, lactate or alanine, as observed in vitro. However, in vivo experiments based on simultaneous ruminal infusions of propionate (up to 1.6 mmol/h per kg BW) and measurements of net portal appearance of nutrients suggest that its conversion to lactate or other products is quantitatively low (Noziè re et al, 2000;Majdoub et al, 2003;Kristensen and Harmon, 2004). Valerate is metabolized to acetyl-coA and propionyl CoA by b-oxidation and can thus produce both b-hydroxybutyrate and lactate in vitro.…”

Section: Metabolism Of Vfa and Glucose By Portal-drained Visceramentioning

confidence: 99%

“…A fixed conversion rate of propionate into glucose is used in Molly (Baldwin et al, 1987a) and in the model of Martin and Sauvant (2007). However, increased availability of propionate does not ensure increased hepatic glucose synthesis (Majdoub et al, 2003;Ortigues-Marty et al, 2003b). A subsequent dynamic model of liver metabolism clearly suggested that in vitro glucose production approaches saturation as propionate supply increases (Baldwin and Freetly, 1995).…”

Section: Metabolism Of Vfa and Glucose By Portal-drained Visceramentioning

confidence: 99%

Carbohydrate quantitative digestion and absorption in ruminants: from feed starch and fibre to nutrients available for tissues

Nozière

Ortigues-Marty

Loncke

et al. 2010

Animal

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Carbohydrates are the main source of energy in ruminants. Their site, extent and kinetics of digestion highly impact the amount and profile of nutrients delivered to peripheral tissues, and the responses of the animal, i.e. ingestion, efficiency of production, N and methane excretion, quality of products and welfare. Development of multi-objective feed evaluation systems thus requires a more integrated quantitative knowledge on carbohydrate digestion and yield of terminal products, as well as on their metabolism by splanchnic tissues. The objective of this paper is to review (i) quantitative knowledge on fibre, starch and sugar digestion, volatile fatty acids (VFA) and glucose production and splanchnic metabolism and (ii) modelling approaches which aim at representing and/or predicting nutrient fluxes in the digestive tract, portal and hepatic drainage. It shows that the representation of carbohydrate digestion and VFA yield is relatively homogeneous among models. Although published quantitative comparisons of these models are scarce, they stress that prediction of fibre digestion and VFA yield and composition is still not good enough for use in feed formulation, whereas prediction of microbial N yield and ruminal starch digestion seems to be more satisfactory. Uncertainties on VFA stoichiometric coefficients and absorption rates may partly explain the poor predictions of VFA. Hardly any mechanistic models have been developed on portal-drained viscera (PDV) metabolism whereas a few exist for liver metabolism. A qualitative comparison of these models is presented. Most are focused on dairy cows and their level of aggregation in the representation of nutrient fluxes and metabolism highly differs depending on their objectives. Quantitative comparison of these models is still lacking. However, recent advances have been achieved with the empirical prediction of VFA and glucose production and fluxes through PDV and liver based on the current INRA feed evaluation system. These advances are presented. They illustrate that empirical prediction of ruminal VFA and intestinal glucose production can be evaluated by comparison with measured net portal net fluxes. We also illustrate the potential synergy between empirical and mechanistic modelling. It is concluded that concomitant empirical and mechanistic approach may likely help to progress towards development of multi-objective feed evaluation systems based on nutrient fluxes.

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“…Seal and Parker [8] infused propionic acid into the rumen of growing steers at rates of 0.5 and 1.0 mol·day -1 , which were lower doses than in the present experiment when compared on a per BW basis, and reported that glucose irreversible loss rate increased at the higher propionic acid infusion rate (1.0 mol·day -1 ). On the contrary, Majdoub et al [7] reported that in growing lambs fed rye grass, the apparent glucose turnover was not modified by intraruminal infusion of propionate (0.55 and 0.91 mol·day -1 ), despite a numerical increase which was due to one of six animals. The inconsistency of effects of supplemental propionate on blood glucose metabolism may be involved in the dose, duration or method of propionate supplementation, the stage of animals, or feeding managements.…”

Section: Discussionmentioning

confidence: 91%

“…Propionate supplementation influences the net flux of glucose in lambs [4] and fat deposition and skeletal muscle growth in wethers [5]. However, the effects of supplementation and intraruminal infusion of propionate on blood glucose kinetics are not persistent in ruminants [6][7][8]. Intraruminal and intravascular infusions of propionate increase the release of insulin and glucagon [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Sano

Fujita

2006

Reprod. Nutr. Dev.

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-An experiment combining a hyperinsulinemic euglycemic clamp procedure of four sequential 2-h periods and an isotope dilution method of [U-13 C]glucose determined the effect of supplemental calcium propionate on blood glucose metabolism during insulin and glucose infusions in adult sheep. They were fed lucerne hay cubes and commercial concentrate with and without supplementary calcium propionate (Prop and Cont diets, respectively) in a crossover design for each 21-day period. At the preinfusion period, blood glucose turnover rate (GTR) was greater (P < 0.05) for the Prop diet than for the Cont diet. Blood GTR, endogenous glucose production rate (EGPR) and the ratio of EGPR to blood GTR were greater (P < 0.01, P < 0.05 and P < 0.05, respectively) for the Prop diet than for the Cont diet. Blood GTR and glucose infusion rate (GIR) increased (P < 0.001) and the ratio of EGPR to blood GTR was reduced (P < 0.01) with increased insulin infusion rates. The maximal GIR tended to be (P < 0.10) greater for the Prop diet than for the Cont diet but plasma insulin concentration at half maximal GIR did not differ between diets. It is suggested that in adult sheep, dietary propionate supplementation enhances insulin action on glucose metabolism, however, changes in measures of tissue responsiveness and sensitivity were not significant. calcium propionate / glucose clamp technique / glucose metabolism / insulin / isotope dilution method / sheep

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Propionate supplementation did not increase whole body glucose turnover in growing lambs fed rye grass

Cited by 4 publications

References 44 publications

Whole body glucose turnover in growing and non-productive adult ruminants: meta-analysis and review

Whole body glucose turnover in growing and non-productive adult ruminants: meta-analysis and review

Carbohydrate quantitative digestion and absorption in ruminants: from feed starch and fibre to nutrients available for tissues

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

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