Prophylaxis with Single-Dose Doxycycline for the Prevention of Lyme Disease after an<i>Ixodes scapularis</i>Tick Bite

Nadelman, Robert B.; Nowakowski, John; Fish, Durland; Falco, Richard C.; Freeman, Katherine; McKenna, Donna; Welch, Peter; Marcus, Robert; Agüero-Rosenfeld, Maria E.; Dennis, David T.; Wormser, Gary P.

doi:10.1056/nejm200107123450201

Cited by 440 publications

(209 citation statements)

References 19 publications

Supporting

Mentioning

188

Contrasting

Unclassified

Order By: Relevance

“…However, a single 200 mg dose of doxycycline effectively prevents Lyme borreliosis when given within 72 h after the tick bite occurs (50).…”

Section: Preventionmentioning

confidence: 99%

Ticks, Borrelia Burgdorferi and Lyme Disease

Bağcı¹,

Ruzicka²

2016

tdd

View full text Add to dashboard Cite

Lyme disease, which is caused by spirochete Borrelia burgdorferi sensu lato, is a ticktransmitted, multisystem infectious disease. It occurs in stages, with different clinical manifestations at each stage. Erythema migrans is the most frequent manifestation which occurs at the site of the tick bite. Borrelial lymphocytoma and acrodermatitis chronica atrophicans are late-stage cutaneous manifestations. Extracutaneous signs of infection most often involve the musculoskeletal, cardiovascular, and nervous systems. Serologic assays remain the mainstay of diagnosis. All stages of the disease are curable with appropriate antibiotic therapy. Keywords: Lyme disease, Borrelia burgdorferi, erythema migrans, acrodermatitis chronica atrophicans, ticks, Ixodes Işın Sinem Bağcı, Thomas Ruzicka* Ticks, Borrelia Burgdorferi and Lyme DiseaseKeneler, Borrelia Burgdorferi ve Lyme Hastalığı Öz AbstractLyme hastalığı Borrelia burgdorferi sensu lato grubu spiroketlerin sebep olduğu multisistemik bir enfeksiyon hastalığıdır. Her hastalık evresi değişik klinik bulgularla kendini gösterir. En sık klinik bulgusu kene ısırık yerinde gelişen eritema migranstır. Borrelial lenfositoma ve akrodermatitis kronika atrofikans geç dönemde gelişen deri bulgularıdır. Deri bulguları dışında kas-iskelet, kardiyovasküler ve sinir sistemi tutulumu da görülebilir. Tanı serolojik testler ile konulur. Hastalığın her evresi uygun antibiyotiklerle tedavi edilebilir.

show abstract

“…However, a single 200 mg dose of doxycycline effectively prevents Lyme borreliosis when given within 72 h after the tick bite occurs (50).…”

Section: Preventionmentioning

confidence: 99%

Ticks, Borrelia Burgdorferi and Lyme Disease

Bağcı¹,

Ruzicka²

2016

tdd

View full text Add to dashboard Cite

show abstract

“…A single 200 mg dose of doxycycline was shown to be 87% effective in preventing Lyme disease if administered within 72 hours in a randomised control trial. 19 This strategy is recommended for individuals who have a tick that has been attached for 36 hours and/or those who remove an engorged deer tick. 5 Although this preventative approach is often used, a meta-analysis showed that 50 people bitten by a deer tick would need prophylaxis to prevent one case of EM.…”

Section: Preventionmentioning

confidence: 99%

Diseases from North America: focus on tick-borne infections

Nathavitharana

Mitty

2015

Clinical Medicine

View full text Add to dashboard Cite

Tick-borne infections are seen throughout the United States, with varying geographical locations. Many of these infections are also increasingly seen in Europe. Certain ticks (eg Ixodes) can transmit more than one infection. Diagnosis, particularly in early infection, can be challenging and therefore knowledge of the distinguishing clinical features and epidemiology of these diseases is important. Testing for Lyme disease often causes confusion for patients and medical providers, as serological tests may be negative in early infection and conversely may be positive for years after infection. Newer tests, such as the C6 ELISA, may play a role in Lyme diagnosis. Additionally, the value of a simple blood fi lm should not be underestimated for diagnosing babesiosis and anaplasmosis. In certain situations, empiric therapy may be required for tick-borne infections as severe illness with multiorgan failure can occur, particularly in older and immunocompromised hosts. This review describes the more commonly seen tick-borne infections: Lyme, babesiosis, anaplasmosis and Rocky Mountain Spotted Fever. More recently identifi ed tick-borne infections, such as southern tick-associated rash illness and Borrelia miyamotoi, are also covered.Tick-borne infections are seen throughout the United States, with varying geographical locations. Diagnosis, particularly in early infection, can be challenging and severe illness can occur. In addition, certain ticks (eg Ixodes scapularis) can transmit more than one infection. This review describes the more commonly seen tick-borne infections. Lyme diseaseIn the United States, Lyme disease is the most common reportable vector-borne disease. 1 It is caused by Borrelia burgdorferii, which is transmitted by the Ixodes tick. This is in contrast to Lyme disease in Europe and Asia that is primarily caused by B afzelii and B garinii. In the US, the Centers for Disease Control and Prevention (CDC) estimates the incidence of Lyme disease to be as high as 300,000 cases per year. 2 The ABSTRACT Authors:

show abstract

“…Однако исследование показало одинаковую высо-кую эффективность применения 10-и 20-дневного курса терапии доксициклином МЭ. Эффективность антимикробной профилактики с использованием доксициклина в дозе 200 мг однократно в первые 72 ч после присасывания клеща спорна [33]. Хороший эффект был получен в результате применения в те-рапии МЭ азитромицина по схеме 1000 мг в 1-й день и по 500 мг ежедневно в течение последующих 4 дней [15].…”

Section: клиническая дерматология и венерология 6 2015unclassified