Prophylaxis with mesna prevents oxidative stress induced by ischemia reperfusion in the intestine via inhibition of nuclear factor‐κB activation

Ypsilantis, Petros; Tentes, Ioannis; Lambropoulou, María; Αναγνωστόπουλος, Κωνσταντίνος; Παπαδόπουλος, Νικόλαος; Kortsaris, Alexandros; Simopoulos, Constantinos

doi:10.1111/j.1440-1746.2007.05154.x

Cited by 35 publications

(50 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 98%

“…However, recent animal studies demonstrate its antioxidant properties in the amelioration or even prevention of oxidative damage induced by I/R injury in kidneys [19], liver [20], and intestine [21,22]. In our previous study, oral pretreatment with mesna at 400 mg/kg, 3 hours before the induction of 60 min ischemia in the rat jejunum, prevented the induction of oxidative stress, keeping the intestinal mucosa literally intact [22]. The oral route of administration proved to be more effective than the intravenous, offering the advantage of delayed absorption and long residence time [31] that should provide prolonged protection against the overproduction of reactive oxygen species during the ischemic and the reperfusion period.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from its uroprotective action, an antioxidative effect against I/R injury in kidneys [19], liver [20], and intestine [21,22] has also been shown. On these grounds, we sought to investigate a potential beneficial effect of mesna's prophylactic administration against pneumoperitoneum-induced oxidative stress in splanchnic organs.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mesna has been shown to inhibit the activation of NF-kB pathway in an ischemia-reperfusion model of the intestine, which leads to decreased oxidative stress. 35 To determine the exact methods of reproductive toxicity caused by cisplatin exposure, future studies need to be conducted to determine the effects of cisplatin and mesna plus cisplatin on the uterus and if uterine dysfunction plays a role in the loss of reproductive function.…”

Section: 27-29mentioning

confidence: 99%

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Yeh¹,

Kim²,

Peresie³

2011

Reproductive Biology Insights

View full text Add to dashboard Cite

Study Objective: Chemical protection against cisplatin, which is a commonly used cancer chemotherapeutic agent, is not well defined. We tested the hypothesis that the antioxidant mesna might protect against the cisplatin-induced repoductive effects in female rats. Design & Setting: Adult female rats were injected with saline, cisplatin alone, or mesna + cisplatin, mated with males, and euthanized on gestational day 17. Patients: Animal Model. Interventions: The administration of either cisplatin or mesna + cisplatin (two injections one week apart, mesna 30 minute pretreatment) followed by mating one week after treatment. Main Outcomes Measured:The number corpora lutea, implantation and resorptions sites, viable and non-viable fetuses, fetal weights, and the level of progesterone per corpus luteum. Results: The administration of cisplatin caused an increase in pre-and post-implantation loss, an increase in the number of resorptions and a decrease in the number of viable fetuses. Mesna administered prior to cisplatin resulted in a decrease in the rate of the pre-and post implantation loss, along with a decrease in the number of resorptions and an increase in the number of live fetuses. Conclusions: Prior exposure to cisplatin caused significant adverse effects on fertility as evidenced by the decreased implantation due to increased fetal loss. The administration of mesna appeared to temper cisplatin damage by lessening the cisplatin effects on fetal resorption.

show abstract

“…Also, a series of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukins-1α, -1β, -6 (IL-1α, IL-1β, IL-6) also are produced (Kelley, 2001). Oxidative stress involving ROS production is an important mediator of inflammation and immune activation (Aw, 1999;Ypsilantis et al, 2008), and ROS can cause injury to the intestinal mucosa (Mercer et al, 1996), but the mechanisms are not understood completely. The present study was designed to explore intestinal oxidative stress, provoked by including oxidized fish oil in the diet of young piglets, in an attempt to explain its influence on the development and immune function of the intestinal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil

Huang

Jiang

et al. 2016

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:To investigate the effect of glycitein, a synthetic soybean isoflavone (ISF), on the intestinal antioxidant capacity, morphology, and cytokine content in young piglets fed oxidized fish oil, 72 4-d-old male piglets were assigned to three treatments. The control group was fed a basal diet containing fresh fish oil, and the other two groups received the same diet except for the substitution with the same dosage of oxidized fish oil alone or with ISF (oxidized fish oil plus ISF). After 21 d of feeding, supplementation of oxidized fish oil increased the levels of malondialdehyde (MDA), oxidized glutathione (GSSG), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), nuclear factor κ B (NF-κB), inducible nitric oxide synthase (iNOS), NO, and Caspase-3 in jejunal mucosa, and decreased the villous height in duodenum and the levels of secretory immunoglobulin A (sIgA) and IL-4 in the jejunal mucosa compared with supplementation with fresh oil. The addition of oxidized fish oil plus ISF partially alleviated this negative effect. The addition of oxidized fish oil plus ISF increased the villous height and levels of sIgA and IL-4 in jejunal mucosa, but decreased the levels of IL-1β and IL-2 in jejunal mucosa (P<0.05) compared with oxidized fish oil. Collectively, these results show that dietary supplementation of ISF could partly alleviate the negative effect of oxidized fish oil by improving the intestinal morphology as well as the antioxidant capacity and immune function in young piglets.

show abstract

Prophylaxis with mesna prevents oxidative stress induced by ischemia reperfusion in the intestine via inhibition of nuclear factor‐κB activation

Abstract: Prophylaxis with mesna prevents oxidative stress induced by I/R in the intestine via inhibition of NF-kappaB activation.

Cited by 35 publications

References 37 publications

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil

Contact Info

Product

Resources

About