Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer – a prospective,randomized, placebo-controlled, double-blind study

Grötz, K. A.; Wüstenberg, P W; Kohnen, Ralf; Al‐Nawas, Bilal; Zepelin, Hans-Heinrich Henneicke-von; Bockisch, Andreas; Kutzner, J; Naser-Hijazi, Belal; Belz, G. G.; Wagner, Wilfried

doi:10.1054/bjom.2000.0459

Cited by 51 publications

(41 citation statements)

References 17 publications

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“…A single clinical trial on a further protection of radiogenic sialadenitis and mucositis by coumarin/troxerutine was also reported by Grotz et al (10). Among the so-called preemptive drugs, pilocarpin has gained ground, not only in experimental studies (11) but in clinical trials as well (12,13).…”

Section: Introductionmentioning

confidence: 88%

A Comparative Study on the Protection Profile of Lidocaine, Amifostine, and Pilocarpin on the Parotid Gland during Radiotherapy

Hakim

Kosmehl²,

Lauer³

et al. 2005

Cancer Research

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The aim of this study was to evaluate the individual and the synergetic radioprotective effect of lidocaine, amifostine, and pilocarpin on the parotid gland. Forty-nine rabbits were randomized into seven groups (n = 7)-control, irradiated sham-treated, irradiated/lidocaine-pretreated, irradiated/ amifostine-pretreated, irradiated/pilocarpin-pretreated, irradiated/lidocaine + pilocarpin-pretreated, and irradiated/ amifostine + pilocarpin-pretreated groups. One week before irradiation (15 Gy) and 72 hours as well as 1 month afterward, the parotid gland was investigated morphologically, sialoscintigraphically, and immunohistochemically with the use of tenascin-C and A smooth muscle actin. Compared with control animals, there was a significant reduction of the salivary ejection fraction in the irradiated untreated group 72 hours following radiation. Only animals pretreated with lidocaine or amifostine (alone or combined with pilocarpin) showed a slight nonsignificant reduction of salivary ejection fraction. Immunohistochemically, we observed a significant loss of A smooth muscle actin and an up-regulation of tenascin-C expression in irradiated/untreated glands. These changes were less evident in animals pretreated with lidocaine or lidocaine + pilocarpin. Amifostine and pilocarpin did not show any influence on tenascin-C or A smooth muscle actin expression. Ultrastructural damage was observed in irradiated untreated and pilocarpin-pretreated glands. In contrast, lidocaine and amifostine could largely preserve the glandular ultrastructure. One month postradiation, all changes were regressive regardless of treatment protocol. Potential radioprotective agents show different effects on both morphology and function of the parotid gland. Associated immunohistochemical and ultrastructural findings could prove the prevailed protection profile of lidocaine. This may provide a prophylactic approach in the field of radioprotection of salivary glands. (Cancer Res 2005; 65(22): 10486-93)

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Section: Introductionmentioning

confidence: 88%

A Comparative Study on the Protection Profile of Lidocaine, Amifostine, and Pilocarpin on the Parotid Gland during Radiotherapy

Hakim

Kosmehl²,

Lauer³

et al. 2005

Cancer Research

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“…The RTOG salivary gland score for late radiation effects was recorded [9]. Sialometry was performed in accordance with the method described earlier [17] and used by other groups [7,8]. We collected stimulated saliva for 5 min in a quiet room outside the medical ambulance in the morning period between 09:00 a.m. and 01:00 p.m. To avoid additional discomfort for the patients when chemical stimulation with citric acid seemed to be impossible (ten cases), we used suggestion techniques to stimulate the flow.…”

Section: Methodsmentioning

confidence: 99%

“…The four-scale RTOG/EORTC rating by the physician seems to be too rough and not free of examiner's influence. The assessment of salivary flow rates is highly susceptible to methodological variances [6,8,17,20,21,29]. Patient ratings of xerostomia are considered to be too subjective to serve as primary endpoints in clinical studies [14].…”

Section: Introductionmentioning

confidence: 99%

Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Al‐Nawas

Al-Nawas²,

Kunkel³

et al. 2006

Strahlenther Onkol

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“…A cumarina é um composto formado por um anel aromático fundido em um anel lactona com potencial para utilização de herbicida (Oliveros-bastidas et al, 2013), perfumes, cosméticos, cigarros (Sullivan, 1982), anti-inflamatório (Leal et al, 2000) além de fins medicinais, como na prevenção e tratamento de edemas consequentes da radioterapia e vários tipos de câncer (Grötz et al, 2001;Mohler et al, 1994;Thornes et al, 1994).…”

Section: Introductionunclassified

Extração Supercrítica Com Utilização De Modificadores E Caracterização a Partir Da Semente De Cumaru (Dipteryx Odorata)

Lima¹,

Ferreira-Pinto²,

Giufrida³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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RESUMO -Este trabalho tem como objetivo a extração e quantificação de compostos bioativos da semente do cumaru por meio de extração convencional (soxhlet) e supercrítica utilizando dióxido de carbono e solventes modificadores. As extrações supercríticas foram realizadas numa faixa de pressão de 180 -220 bar e temperatura de 60 -80ºC. O planejamento experimental foi definido a partir do design fatorial fracionado (método Taguchi). Os extratos foram analisados por cromatografia liquida (HPLC) e gasosa com espectrofotômetro de massas (GC-MS). A extração da cumarina utilizando o dióxido de carbono e modificados apresentou melhor seletividade e rendimentos em relação à extração convencional.

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Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer – a prospective,randomized, placebo-controlled, double-blind study

Cited by 51 publications

References 17 publications

A Comparative Study on the Protection Profile of Lidocaine, Amifostine, and Pilocarpin on the Parotid Gland during Radiotherapy

A Comparative Study on the Protection Profile of Lidocaine, Amifostine, and Pilocarpin on the Parotid Gland during Radiotherapy

Quantifying Radioxerostomia: Salivary Flow Rate, Examiner’s Score, and Quality of Life Questionnaire

Extração Supercrítica Com Utilização De Modificadores E Caracterização a Partir Da Semente De Cumaru (Dipteryx Odorata)

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