Prophylactic use of phenoxymethylpenicillin and tinidazole in mandibular third molar surgery, a comparative placebo controlled clinical trial

Happonen, Risto‐Pekka; Bäckström, A C; Ylipaavalniemi, P

doi:10.1016/0266-4356(90)90003-4

Cited by 69 publications

(27 citation statements)

References 14 publications

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“…13 When the preoperative and postoperative measurements were compared, in most of the previous studies, the antibiotics which were used postoperatively did not differ significantly in their effects when prescribed for decreased maximal opening of mouth. 14 The present study shows that there was a statistically significant difference between the study groups with regard to mouth opening, on day 3 and 5. Patients with no pain were significantly more in group II followed by group I on day 5.…”

supporting

confidence: 45%

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Rabi

Maheshwari

Bhuvaneshwari

et al. 2018

The Journal of Contemporary Dental Practice

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Aim: The present study was conducted with the aim of evaluating the effectiveness of antimicrobial therapy following extraction of an impacted mandibular third molar. Materials and methods:This randomized controlled trial was conducted on a total of 60 patients who were randomly assigned into three groups: Group I individuals were given 625 mg of combined amoxicillin and clavulanic acid tablet; 625 mg of combined amoxicillin and clavulanic acid tablet + 400 mg metronidazole tablet was given to group II individuals; whereas group III individuals were assigned no treatment. All the individuals underwent surgical extraction of impacted mandibular third molars under strict aseptic techniques, with minimal trauma to the surrounding tissues. Mouth opening in millimeters was recorded postoperatively using Vernier calipers on the 1st, 3rd, 5th, and 7th days. A 4-point visual analog scale (VAS) was used for assessing postoperative pain. Patient satisfaction was further assessed in a subjective manner using a graded scale from "very satisfied" to "very unsatisfied". better satisfaction than the other group individuals. There was no statistically significant difference between the mean age of groups. It was observed that on day 3, the number of individuals with severe pain was slightly reduced in the group I compared with group III individuals. On day 5, participants with no pain were significantly more in group II followed by group I. Furthermore, there was a statistically significant difference between the study groups with respect to mouth opening on days 3 and 5. Results Conclusion:It was concluded from this trial that the administration of postoperative antimicrobials showed no significant differences in the degree of postoperative complications that occur following the surgical extraction of impacted mandibular third molars.Clinical significance: Antimicrobial drugs are routinely used to reduce the chances of surgical site infection, either preoperatively or postoperatively. Therefore, the clinicians should have sound knowledge about choosing the better antimicrobial drug after the extraction of impacted third molars.

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supporting

confidence: 45%

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Rabi

Maheshwari

Bhuvaneshwari

et al. 2018

The Journal of Contemporary Dental Practice

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“…Conversely, evidence exists that the prophylactic use of antimicrobials in minor oral surgery has no effect on post operative pain, swelling, infection or wound healing. 18,29 It is the view of the authors that this should include implants, assuming they are placed in an aseptic environment. It has been shown that antibiotics do not provide significant advantages concerning postoperative infections in the presence of good asepsis.…”

Section: Discussionmentioning

confidence: 99%

“…12 In minor oral surgery there is no evidence for the prophylactic use of antimicrobials to prevent postoperative infection in healthy patients as a result of surgical removal of impacted teeth or roots. 18 Conversely, evidence exists that prophylactic use of antimicrobials has no effect on postoperative pain, swelling, infection or wound healing. 19,20 The research to date with regard to efficacy of antimicrobial prophylaxis in reducing failure of integration of implants and reducing postoperative complications remains equivocal.…”

Section: Introductionmentioning

confidence: 99%

An investigation of antibiotic prophylaxis in implant practice in the UK

et al. 2012

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“…It is estimated that 6-7 % of patients who are given antibiotics have some kind of adverse reaction [6]. The estimated rate of infection after removal of an impacted third molar is \1 %, so the usage of such drugs is questionable [13,16]. An important point in the debate about usage of prophylactic antibiotics is its timing of administration.…”

Section: Resultsmentioning

confidence: 99%

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

Sane

Gadre

Chandan

et al. 2013

J. Maxillofac. Oral Surg.

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Surgical removal of impacted mandibular third molar (SRIMTM) is the most common procedure performed in oral and maxillofacial surgery. In the literature, many complications associated with lower third molar removal are described such as pain, swelling, trismus, infection, inflammation, and nerve damage. Antibiotics are routinely used either pre-operatively or post-operatively to reduce the chances of surgical site infection (SSI). However routine use of antibiotics for SRIMTM is still controversial. For antibiotics to be effective in reducing post-operative infective complications, the time of administration is very important. Adequate serum concentration of antibiotic must be achieved prior to the procedure. In a developing country like India, antibiotics are routinely prescribed post-operatively. The current study is designed to evaluate the efficacy of post-operative prophylactic antibiotic in SRIMTM.

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Prophylactic use of phenoxymethylpenicillin and tinidazole in mandibular third molar surgery, a comparative placebo controlled clinical trial

Cited by 69 publications

References 14 publications

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

Effectiveness of Antimicrobial Therapy after Extraction of Impacted Mandibular Third Molar: A Randomized Clinical Trial

An investigation of antibiotic prophylaxis in implant practice in the UK

Is Post-Operative Antibiotic Therapy Justified for Surgical Removal of Mandibular Third Molar? A Comparative Study

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