Prophylactic Use of Methotrexate and 6-Mercaptopurine for Prevention of Choriocarcinoma Following Molar Pregnancy

Chun, Daphne; K., H.; Yip, Shing‐Kai

doi:10.1111/j.1447-0756.1970.tb00126.x

Cited by 6 publications

(1 citation statement)

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“…(4,9,17) The toxicity of prophylactic chemotherapy has been reported to occur in 20% to 60% cases. (15,18,19) Deaths due to toxicity have also been reported. It depends upon the dose of chemotherapeutic agent used .In present study; low dose oral methotrexate has been used.…”

Section: Discussionmentioning

confidence: 99%

Hemoptysis With Normal Chest Roentgenogram In A Former Smoker

2011

IJPM

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The study was done with the aim to find out the effect of prophylactic chemotherapy on regression pattern of serum β-HCG and on the incidence of persistent trophoblastic disease in patients with high risk complete hydatidiform mole. Methods Out of 43 patients of complete hydatidiform mole diagnosed over a period of 1 year, 24 were categorised as high risk on the basis of Curry criteria. After suction and evacuation , 12 out of 24 high risk patients were given prophylactic chemotherapy in the form of low dose oral methotrexate (chemoprophylaxis group) and other 12 high risk patients served as control (control group) . Follow up was done clinically and with serum β-HCG levels. Results All 12 patients of chemoprophylaxis group had benign regression of the disease and none of them developed persistent trophoblastic disease. In control group, 4 (33%) out of 12 patients had persistent trophoblastic disease. There was rapid fall of serum β-HCG in chemoprophylaxis group in mean time of 7.3 weeks as against 9.7 weeks in control group. No serious toxicity was observed with chemotherapy. Conclusion Prophylactic chemotherapy reduces the occurrence of persistent trophoblastic disease in high risk hydatidiform mole patients without causing any life threatening toxicity.

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Section: Discussionmentioning

confidence: 99%

Hemoptysis With Normal Chest Roentgenogram In A Former Smoker

2011

IJPM

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Prophylactic chemotherapy for hydatidiform mole five to 15 years follow-up

Kashimura

Sugimori

et al. 1986

Cancer

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The effectiveness of the prophylactic chemotherapy was evaluated in 420 patients with molar pregnancy. All patients were followed for 5 to 15 years after the evacuation. Twenty-two (7.5%) of 293 patients with prophylactic chemotherapy and 23 (18.1%) of 127 patients without prophylactic chemotherapy (control) developed secondary trophoblastic disease. The prophylactic chemotherapy could reduce the occurrence of secondary trophoblastic disease. In these secondary trophoblastic diseases, 5 (22.7%) of 22 patients in the prophylactic chemotherapy group and 5 (21.7%) of 23 in the control had metastatic trophoblastic disease. Choriocarcinoma after the molar pregnancy developed in two patients (0.7%) of the prophylactic chemotherapy group and two (1.6%) of the control. Prophylactic chemotherapy did not eliminate the occurrence of choriocarcinoma. The complication of the prophylactic chemotherapy was seen in 27.3% of the patients. Neither severe complication nor death were related to the toxicity.

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The Malignant Sequelae of Hydatidiform Mole

Teoh

Ratnam

1973

Intl J Gynecology & Obste

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Prophylactic Use of Methotrexate and 6-Mercaptopurine for Prevention of Choriocarcinoma Following Molar Pregnancy

Cited by 6 publications

References 9 publications

Hemoptysis With Normal Chest Roentgenogram In A Former Smoker

Hemoptysis With Normal Chest Roentgenogram In A Former Smoker

Prophylactic chemotherapy for hydatidiform mole five to 15 years follow-up

The Malignant Sequelae of Hydatidiform Mole

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