Prophylactic use of ergot alkaloids in the third stage of labour

Liabsuetrakul, Tippawan; Choobun, Thanapan; Peeyananjarassri, Krantarat; Islam, Q Monir

doi:10.1002/14651858.cd005456.pub2

Cited by 69 publications

(13 citation statements)

References 68 publications

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“…However, ergometrine and methylergometrine are unstable in heat with an unpredictable bioavailability, which precludes oral use (de Groot 1996). They are vasoconstrictive and increase the risk of hypertension postpartum (Liabsuetrakul 2007). Other side-effects with ergot alkaloids are pain after birth, nausea and vomiting (Liabsuetrakul 2007).…”

Section: Ergometrinementioning

confidence: 99%

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Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

Gallos

Williams

Price

et al. 2015

Cochrane Database of Systematic Reviews

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Section: Ergometrinementioning

confidence: 99%

“…They are vasoconstrictive and increase the risk of hypertension postpartum (Liabsuetrakul 2007). Other side-effects with ergot alkaloids are pain after birth, nausea and vomiting (Liabsuetrakul 2007).…”

Section: Ergometrinementioning

confidence: 99%

Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

Gallos

Williams

Price

et al. 2015

Cochrane Database of Systematic Reviews

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“…Prendiville et al in their Cochrane Systematic review, due to be updated, found that active management halves the risk of postpartum haemorrhage compared with expectant management [4]. Much of this reduction is due to the prophylactic uterotonic drug: [6,7] oxytocin is the drug of choice, as it has comparable impact on blood loss with fewer adverse effects than ergot alkoids [6]. The impact of other components, such as when is best to give the uterotonic [8], when to clamp the cord [9] and whether to use controlled cord traction [10], is unclear.…”

Section: Introductionmentioning

confidence: 99%

Policies for care during the third stage of labour: a survey of maternity units in Syria

Matar

Almerie

Alsabbagh

et al. 2010

BMC Pregnancy Childbirth

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BackgroundCare for women during the third stage aims to reduce the risk of major haemorrhage, but is very variable. The current World Health Organisation (WHO) recommendation is that care should include administration of a uterotonic (oxytocin, if it is available) soon after birth of the baby, delayed cord clamping, and delivery of the placenta by controlled cord traction.MethodsTo ascertain care policies used during the third stage of labour in maternity units in Syria, we conducted a survey of 69 maternity units in obstetric and general public hospitals. A brief questionnaire was administered by face to face interview or telephone with senior obstetricians and midwives. Outcome measures were the use of prophylactic uterotonic drugs, timing of cord clamping, use of controlled cord traction, and treatment for postpartum haemorrhage. Obstetricians were asked about both vaginal and caesarean births, midwives only about vaginal births.ResultsResponses were obtained for 66 (96%) hospitals: a midwife and an obstetrician were interviewed in 40; an obstetrician only in 20; a midwife only in 6. Responses were similar, although midwives were more likely to report that the umbilical cord was clamped after 1-3 minutes or after cessation of pulsation (2/40 obstetricians and 9/40 midwives). Responses have therefore been combined.One hospital reported never using a prophylactic uterotonic drug. The uterotonic was Syntometrine® (oxytocin and ergometrine) in two thirds of hospitals; given after delivery of the placenta in 60 (91%) for vaginal births, and in 47 (78%) for caesarean births. Cord clamping was within 20 seconds at 42 hospitals 64%) for vaginal births and 45 (75%) for caesarean births. Controlled cord traction was never used in a quarter (17/66) of hospitals for vaginal births and a half (32/60) for caesarean births.68% of respondents (45/66) thought there was a need for more randomised trials of interventions during the third stage of labour.ConclusionMost maternity units report using Syntometrine®, usually given after delivery of the placenta, clamping the cord within 20 seconds, and using controlled cord traction.

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“…Studies revealed that plant extracts rich in alkaloids (Liabsuetrakul et al, 2007), glycosides, tannins, flavonoids (Lakshmi et al, 2014), saponins (Dande and Patil, 2012) and steroids have abortifacient potential (Kumar et al, 2012). The abortifacient activity of MEACmay be because of these phytoconstituents acting alone or in combination.…”

Section: Discussionmentioning

confidence: 99%

Abortifacient potential of methanolic extract of Anthocephalus cadamba stem bark in mice

Shaikh

Kala

Ravat

et al. 2015

Journal of Ethnopharmacology

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Prophylactic use of ergot alkaloids in the third stage of labour

Abstract: Background Previous research has shown that the prophylactic use of uterotonic agents in the third stage of labour reduces postpartum blood loss and moderate to severe postpartum haemorrhage (PPH). PPH is defined as a blood loss of 500 mL or more within 24 hours after birth.

Cited by 69 publications

References 68 publications

Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

Policies for care during the third stage of labour: a survey of maternity units in Syria

Abortifacient potential of methanolic extract of Anthocephalus cadamba stem bark in mice

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