2017
DOI: 10.1371/journal.pone.0181535
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Prophylactic supplementation of resveratrol is more effective than its therapeutic use against doxorubicin induced cardiotoxicity

Abstract: Resveratrol (RSV), a polyphenolic compound and naturally occurring phytoalexin, has been reported to exert cardio-protective effects in several animal studies. However, the outcome of initial clinical trials with RSV was less effective compared to pre-clinical studies. Therefore, RSV treatment protocols need to be optimized. In this study we evaluated prophylactic versus therapeutic effect of resveratrol (RSV) in mitigating doxorubicin (Dox)-induced cardiac toxicity in rats. To investigate prophylactic effects… Show more

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Cited by 42 publications
(37 citation statements)
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References 49 publications
(67 reference statements)
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“…Here, we found a marked reduction in left ventricular end-diastolic posterior wall thickness, ejection fraction, and fractional shortening percentage in Dox-treated rats, concomitantly with increased cardiomyocyte membrane permeability and serum LDH concentration. This was consistent with previous studies in several animal models [8,19,33]. However, upregulation of miR-29b was effective in improving cardiac function.…”
Section: Discussionsupporting
confidence: 93%
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“…Here, we found a marked reduction in left ventricular end-diastolic posterior wall thickness, ejection fraction, and fractional shortening percentage in Dox-treated rats, concomitantly with increased cardiomyocyte membrane permeability and serum LDH concentration. This was consistent with previous studies in several animal models [8,19,33]. However, upregulation of miR-29b was effective in improving cardiac function.…”
Section: Discussionsupporting
confidence: 93%
“…However, its potential usage is largely limited due to its cardiotoxicity, which was reported to be fatal in some cases [2,6]. Dox cardiotoxicity features a reduction of ejection fraction and thinning and dilatation of the ventricular wall [8]. Here, we found a marked reduction in left ventricular end-diastolic posterior wall thickness, ejection fraction, and fractional shortening percentage in Dox-treated rats, concomitantly with increased cardiomyocyte membrane permeability and serum LDH concentration.…”
Section: Discussionmentioning
confidence: 51%
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“…It is likely that resveratrol‐induced SIRT1 activation may also be involved in these cardioprotective effects . Into the future, resveratrol is projected as a possible adjuvant to minimize doxorubicin‐induced cardiotoxicity in cancer patients …”
Section: Molecular Targets Of Resveratrol In Humansmentioning
confidence: 99%