Prophylactic Residual Aneurysmal Sac Embolization with Expandable Hydrogel Embolic Devices for Endoleak Prevention: Preliminary Study in Dogs

Hiraki, Takao; Pavčnik, Dušan; Uchida, Barry T.; Timmermans, Hans A.; Yin, Qiang; Wu, Reng Hong; Niyyati, Mahtab; Keller, Frederick S.; Rösch, Josef

doi:10.1007/s00270-004-4047-9

Cited by 9 publications

(9 citation statements)

References 15 publications

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“…58 After endoluminal exclusion, the residual aneurysm sac was prophylactically embolized with an expandable hydrogel embolic device made of polyacrylamide-co-acrylic acid.…”

Section: Techniques To Treat Type II Endoleakmentioning

confidence: 99%

Basic Science Review: Characterization of Endoleak Following Endovascular Repair of Abdominal Aortic Aneurysms

Chaer

DeRubertis

Trocciola

et al. 2007

Vasc Endovascular Surg

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“…58 After endoluminal exclusion, the residual aneurysm sac was prophylactically embolized with an expandable hydrogel embolic device made of polyacrylamide-co-acrylic acid.…”

Section: Techniques To Treat Type II Endoleakmentioning

confidence: 99%

Basic Science Review: Characterization of Endoleak Following Endovascular Repair of Abdominal Aortic Aneurysms

Chaer

DeRubertis

Trocciola

et al. 2007

Vasc Endovascular Surg

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“…58 Following endoluminal exclusion, the residual aneurysm sac was prophylactically embolized with an expandable hydrogel embolic device made of polyacrylamide-coacrylic acid.…”

Section: Experimental Models Of Type 2 Endoleakmentioning

confidence: 99%

Models of Abdominal Aortic Aneurysm: Characterization and Clinical Applications

et al. 2006

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Abdominal aortic aneurysms (AAAs) are responsible for considerable morbidity, mortality, and cost to society. The pathogenesis of AAA formation, however, remains poorly understood. Animal models have been used in a range of experiments designed to provide further objective scientific assessment of the pathogenesis as well as the treatment of AAA. The purpose of this manuscript is to review the current models of AAA and their potential clinical implications.

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“…In one model, in addition to a modified aortic stent-graft, a non-cytotoxic polymer was employed consisting of 2 ml of n-butyl-2-cyanoacrylate-metacryloxysulpholane glue and ultrafluid lipiodol (ratio 20:80) [217]. In a similar model, an embolization of the residual AAA sac was proposed with an expandable hydrogel embolic device to prevent endoleaks [218]. In a similar model, an embolization of the residual AAA sac was proposed with an expandable hydrogel embolic device to prevent endoleaks [218].…”

Section: Experimental Models For Endovascular Aaa Repair (Evar)mentioning

confidence: 99%

“…While control animals demonstrated both type I and II endoleaks, none of the swines undergoing embolization showed any type of endoleaks [217]. The hydrogel was poly(acrylamide-co-acrylic acid), which is biodegradable and does not adhere to tissues [218]. The device consisted of a combination of hydrogel (for occlusion) and platinum wire or coil (for radiopacity and to aid in delivery).…”

Section: Experimental Models For Endovascular Aaa Repair (Evar)mentioning

confidence: 99%

“…In a similar model, an embolization of the residual AAA sac was proposed with an expandable hydrogel embolic device to prevent endoleaks [218]. The conclusion reached was that although residual AAA sac embolization was technically feasible with the expandable hydrogel embolic device, additional modifications to the device and further development of the model were necessary to avoid complications [218]. The hydrogel was poly(acrylamide-co-acrylic acid), which is biodegradable and does not adhere to tissues [218].…”

Section: Experimental Models For Endovascular Aaa Repair (Evar)mentioning

confidence: 99%

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Experimental Models of Abdominal Aortic Aneurysms: An Overview

Paraskevas

Mikhailidis²,

Perrea³

2008

CPD

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In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons.The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.

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Prophylactic Residual Aneurysmal Sac Embolization with Expandable Hydrogel Embolic Devices for Endoleak Prevention: Preliminary Study in Dogs

Abstract: RAS embolization was feasible with the EHED, although additional modifications to the device are required to avoid complications. Angiographic and histologic results suggested that RAS embolization with the EHED may help in the prevention of endoleaks.

Cited by 9 publications

References 15 publications

Basic Science Review: Characterization of Endoleak Following Endovascular Repair of Abdominal Aortic Aneurysms

Basic Science Review: Characterization of Endoleak Following Endovascular Repair of Abdominal Aortic Aneurysms

Models of Abdominal Aortic Aneurysm: Characterization and Clinical Applications

Experimental Models of Abdominal Aortic Aneurysms: An Overview

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