Prophylactic Ondansetron in Prevention of Postoperative Nausea and Vomiting following Pediatric Strabismus Surgery

Sadhasivam, Senthilkumar; Shende, Dilip; Madan, Rashmi

doi:10.1097/00000542-200004000-00021

Cited by 74 publications

(34 citation statements)

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“…The incidence of PONV in our palonosetron groups was similar to that reported in previous 5-HT 3 inhibitor studies. [21,24,25] The elimination half-life of palonosetron (reported to be approximately 40 hours [13] ) is longer than that of other 5-HT 3 receptor antagonists (e.g. granisetron 5-8 hours, ondansetron 3-5 hours, ramosetron 4.3-9 hours, tropisetron 8 hours).…”

Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

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Background: Postoperative vomiting is a common complication after strabismus surgery in children. The serotonin 5-HT 3 receptor antagonists have proven to be a particularly valuable addition to the armamentarium against postoperative nausea and vomiting (PONV). Palonosetron is a secondgeneration 5-HT 3 receptor antagonist that has recently been approved for prophylaxis against PONV. Objective: The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery. Patients and Method: A total of 150 children who were classified with an American Society of Anesthesiologists physical status of I, were aged between 2 and 12 years, and were undergoing strabismus surgery under general anesthesia were enrolled in the study. A random numbers table was used to assign each child to receive palonosetron 0.5, 1.0, or 1.5 mg/kg (n = 50 in each group). All episodes of PONV at the intervals of 0-2, 2-6, 6-24, and 24-48 hours were evaluated using a numeric scoring system for PONV. A p-value of <0.05 was considered statistically significant. Results: The percentage of children with PONV during 0-48 hours after anesthesia was 24% with palonosetron 0.5 or 1.0 mg/kg, and 20% with palonosetron 1.5 mg/kg. There was no statistically significant difference between the study groups with respect to the number of children with PONV scores of 1, 2, or 3 during 0-48 hours after anesthesia. There was no statistically significant difference between the study groups with respect to the number of children with postoperative vomiting during all time periods after anesthesia. The percentage of children aged >6 years with postoperative nausea during 0-48 hours after anesthesia was 8.6%, 18.2%, and 15.4% with palonosetron 0.5, 1.0, or 1.5 mg/kg, respectively, but there was no statistically significant difference between the study groups.

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Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

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“…[1][2][3][4][5][6] Vitreoretinal (VR) surgery and surgery for retinal detachment (RD) in children has been inadequately studied, although widely performed in children of all age groups. The strict need for immobility has resulted in general anesthesia (GA) traditionally being pre-ferred for VR surgery.…”

mentioning

confidence: 99%

Usefulness of pre-emptive peribulbar block in pediatric vitreoretinal surgery: A prospective study

Subramaniam

Subbarayudu²,

Rewari³

et al. 2003

Regional Anesthesia and Pain Medicine

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“…[21,24,25] The elimination half-life of palonosetron (reported to be approximately 40 hours[13] ) is longer than that of other 5-HT 3 receptor antagonists (e.g. granisetron 5–8 hours, ondansetron 3–5 hours, ramosetron 4.3–9 hours, tropisetron 8 hours).…”

Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

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Objective: The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery.Patients and Method: A total of 150 children who were classified with an American Society of Anesthesiologists physical status of I, were aged between 2 and 12 years, and were undergoing strabismus surgery under general anesthesia were enrolled in the study. A random numbers table was used to assign each child to receive palonosetron 0.5, 1.0, or 1.5 μg/kg (n = 50 in each group).All episodes of PONVat the intervals of 0–2, 2–6, 6–24, and 24–48 hours were evaluated using a numeric scoring system for PONV. A p-value of <0.05 was considered statistically significant.Results: The percentage of children with PONV during 0–48 hours after anesthesia was 24% with palonosetron 0.5 or 1.0 μg/kg, and 20% with palonosetron 1.5 μg/kg. There was no statistically significant difference between the study groups with respect to the number of children with PONV scores of 1, 2, or 3 during 0–48 hours after anesthesia. There was no statistically significant difference between the study groups with respect to the number of children with postoperative vomiting during all time periods after anesthesia. The percentage of children aged >6 years with postoperative nausea during 0–48 hours after anesthesia was 8.6%, 18.2%, and 15.4% with palonosetron 0.5, 1.0, or 1.5 μg/kg, respectively, but there was no statistically significant difference between the study groups.Conclusion: Palonosetron doses of 0.5, 1.0, and 1.5 μg/kg are recommended for further evaluation, as they appear to be the effective doses for the prevention of PONV following strabismus surgery in children.

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Prophylactic Ondansetron in Prevention of Postoperative Nausea and Vomiting following Pediatric Strabismus Surgery

Abstract: The routine prophylactic use of ondansetron at a dose of 75 microg/kg is as effective as 150 microg/kg in preventing PONV and improving the "true" outcome measures after strabismus repair in children.

Cited by 74 publications

References 0 publications

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

Usefulness of pre-emptive peribulbar block in pediatric vitreoretinal surgery: A prospective study

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

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