Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour

McDonald, Susan; Abbott, Jo; Higgins, Shane

doi:10.1002/14651858.cd000201.pub2

Cited by 139 publications

(115 citation statements)

References 26 publications

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“…The results of our study were comparable with that of the other studies. Mcdonald and Abbott (2007-cochrane review) [10] compared effects of oxytocin with ergometrine-oxytocin in reducing risk of PPH (i.e. blood loss of 500 ml) and found that ergometrine-oxytocin was associated with small reduction in the risk of PPH (odds ratio = 0.82) but more of nausea, vomiting and hypertension.…”

Section: Resultsmentioning

confidence: 99%

A Study to Compare the Efficacy of Misoprostol, Oxytocin, Methyl-ergometrine and Ergometrine–Oxytocin in Reducing Blood Loss in Active Management of 3rd Stage of Labor

Gohil

Tripathi

2011

J Obstet Gynecol India

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Objectives The purpose of the study was to compare the efficacy of misoprostol 400 lg per rectally, injection oxytocin 10 IU intramuscular, injection methylergometrine 0.2 mg intravenously and injection (0.5 mg ergometrine ? 5 IU oxytocin) intramuscular on reducing blood loss in third stage of labor, duration of third stage of labor, effect on haemoglobin of the patient, need of additional oxytocics or blood transfusion and associated side effects and complications. Study Design A prospective non-randomized uncontrolled study was carried out in the Department of Obstetrics and Gynecology, SSG Hospital and Medical College, Baroda enrolling 200 women and dividing them into four groups. Active management of 3rd stage of labor was done using one of the 4 uterotonics as per the group of the patient. The main outcome measures were the amount of blood loss, the incidence of postpartum hemorrhage and a drop in hemoglobin concentration from before delivery to 24 h after delivery. Results Methylergometrine was found to be superior to rest of the drugs in the study with lowest duration of third stage of labor (P = 0.000096), lowest amount of blood loss (P = 0.000017) and lowest incidence of PPH (P = 0.03). There was no significant difference in the pre-delivery and the post-delivery hemoglobin concentration amongst the four groups with P = 0.061. The need of additional oxytocics and blood transfusion was highest with misoprostol as compared to all other drugs used in the study with P = 0.037 and 0.009, respectively. As regards side effects, misoprostol was associated with shivering and pyrexia in significantly high number of patients as compared to the other drugs used in the study while nausea, vomiting and headache were more associated with methylergometrine and ergometrine-oxytocin. However all the side effects were acceptable and preferable to the excessive blood loss. Conclusion Methylergometrine has the best uterotonic drug profile amongst the drugs used, strongly favouring its routine use as oxytocic for active management of third stage of labor. Misoprostol was found to cause a higher blood loss compared to other drugs and hence should be used only in low resource setting where other drugs are not available. The role of misoprostol in third stage of labor needs larger studies to be proved.Keywords Uterotonics Á 3rd stage of labor Á Post-partum hemorrhage Á Brass-V drapes

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Section: Resultsmentioning

confidence: 99%

A Study to Compare the Efficacy of Misoprostol, Oxytocin, Methyl-ergometrine and Ergometrine–Oxytocin in Reducing Blood Loss in Active Management of 3rd Stage of Labor

Gohil

Tripathi

2011

J Obstet Gynecol India

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“…Administration of Oxytocin has been found to be associated with lesser blood loss in the third stage than expectant management. 12,13 But oxytocin need storage at low temperatures and a skilled person to administer the drug by intramuscular (IM) or intravenous (IV) route, which are not feasible in rural areas of resource poor countries like India.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of efficacy of oxytocin, methylergometrine and misoprostol in prevention of post-partum haemorrhage

Alam

Shyam

Goswami

2017

Int J Reprod Contracept Obstet Gynecol

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Background: To compare the efficacy of oxytocin, methylergometrine and misoprostol in active management of third stage of labour (AMTSL).Methods: A clinical study was conducted on 330 low risk pregnant women with a healthy singleton pregnancy and spontaneous onset of labour at term; allocated into three groups where active management of third stage of labour was done with either Oxytocin 10 IU intramuscular, or Methylergometrine 0.2 mg intramuscular, or tab Misoprostol 600µg sublingual on 110 women each group. Primary parameter was blood loss during labour. Secondary parameters were the duration of third stage of labour and changes in haemoglobin level.Results: Blood loss during labour in Oxytocin group was 145.86±11.53 ml, which was significantly less than that in Methylergometrine (164.02±9.36 ml) and Misoprostol groups (183.18±9.70 ml), but no patient in any of the groups had blood loss more than 200ml. Duration of third stage of labour was significantly less in Oxytocin group (5.13±1.91 mins) than in. Methylergometrine (6.16±1.85 mins), and Misoprostol groups (6.47±1.51 mins). No patient had prolonged third stage in any of the groups. There was no significant change in pre-and post-delivery haemoglobin levels in all the groups.Conclusions: Though injectable uterotonics are effective for active management of third stage of labour (AMTSL), misoprostol can also be effectively used, especially in settings where there is no adequate trained personnel and drug storage facility.

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“…In McDonald [6] study, it was observed that delayed cord clamping may help prevent iron-deficiency anemia during the first year of life [6]. On the other hand, iron deficiency anemia affect millions of children worldwide and in Saudi Arabia more than 350\100000 of infants are anemic before 6 months of age [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Early and Late Clamping of the Umbilical Cord on the Newborns Blood Analysis

Ninia¹,

Ashmauey²,

Qahtani³

2017

J Nurs Health Stud

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Background: At the time of birth, the infant is still attached to the mother via the umbilical cord, which is a part of the placenta. The infant is usually separated from the placenta by clamping the cord. Timing of umbilical cord clamping has been and still is a highly controversial issue worldwide, the controversy about the best time to clamp the cord. The main aim of the study is to identify the effect of early and late cord clamping on newborns' blood analysis.

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Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour

Abstract: Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour (Review)

Cited by 139 publications

References 26 publications

A Study to Compare the Efficacy of Misoprostol, Oxytocin, Methyl-ergometrine and Ergometrine–Oxytocin in Reducing Blood Loss in Active Management of 3rd Stage of Labor

A Study to Compare the Efficacy of Misoprostol, Oxytocin, Methyl-ergometrine and Ergometrine–Oxytocin in Reducing Blood Loss in Active Management of 3rd Stage of Labor

A comparative study of efficacy of oxytocin, methylergometrine and misoprostol in prevention of post-partum haemorrhage

Effect of Early and Late Clamping of the Umbilical Cord on the Newborns Blood Analysis

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