Prophylactic efficacy of moxidectin for periparturient ewes and mid-summer lambs

Taylor, Subhashni; Edgar, H.W.J.; Kenny, J.

doi:10.1136/vr.133.11.270

Cited by 20 publications

(15 citation statements)

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“…There is no readily available good explanation for that. Moxidectin has been found to be highly efficacious against the most important nematode parasites of cattle and sheep (Ranjan et al 1992, Taylor et al 1993, as has ivermectin (Campbell & Benz 1984). In the present trial, both moxidectin and ivermectin showed high efficacy against trichostrongylids in reindeer.…”

Section: Discussionmentioning

confidence: 99%

“…The long depletion half life causes that the persistent activity of moxidectin against nematode infections in domestic ruminants is longer (Taylor et al, 1993;Hubert et al, 1995). Injectable moxidectin at 200 ug/kg is reported to have high efficacy against cattle warbles (Hypoderma lineatum) , but there is also a report on poor efficacy of oral moxidectin at 400 ug/kg against third instar larvae of the equine bots Gasterophilus spp.…”

Section: Moxidectinmentioning

confidence: 99%

“…1995). The persistent efficacy of moxidectin was greater than that of ivermectin against ovine trichostrongylids (Taylor et al 1993) and against induced Dictyocaulus viviparus and Ostertagia ostertagi infections in cattle (Hubert et al 1995, Barth et al 1997. Avermectins and milbemycins are called endectocides because of their broad spectrum efficacy against both endo-and ectoparasites (nematodes, insects and arachnids).…”

Section: Introductionmentioning

confidence: 99%

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Antti Oksanen; Endectocide treatment of the reindeer

Oksanen¹

1999

Ran

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Section: Discussionmentioning

confidence: 99%

Section: Moxidectinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antti Oksanen; Endectocide treatment of the reindeer

Oksanen¹

1999

Ran

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“…Eleven days before inserting the Captec devices, all animals were faecal-sampled for FEC analysis (April FEC, Day -11), and then treated orally at a dose rate of 0.2 mg/kg with the anthelmintic moxidectin ("Cydectin", Cyanamid of New Zealand Ltd). This drench was believed to be effective for at least 28 days against Haemonchus and Ostertagia species (Taylor et al 1993), therefore providing internal parasite control until the last day (Day 17) of the food intake trial. Subsequently persistent-activity claims, now published by the manufacturers, are for control of Haemonchus for 35 days, Ostertagia for 21 days, and Trichostrongylus for 7 days.…”

Section: Food Intake Studymentioning

confidence: 99%

Faecal egg count and food intake comparisons of Romney single‐trait selection and control lines

Morris

Clarke

Watson

et al. 1996

New Zealand Journal of Agricultural Research

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Two sets of correlated responses were studied in five Romney selection lines and their controls. The lines were from one experiment selecting for yearling body weight or yearling fleece weight since 1967, from a second experiment selecting for weaning weight or yearling fleece weight since 1973, and from a third experiment selecting for yearling body weight since 1973. Overall, the five selection lines were evaluated whilst being run together with controls at a single site. The responses were faecal egg count (FEC) after weaning, using lamb crops born in 1990-93, and food intake using 1993-born 7-month-old ram lambs. Four or five new sires were used per line per year, with 1471 and 232 animals being recorded for FEC and food intake respectively. The three body weight lines were each 20-22% heavier than their respective controls in March (6 months of age) and May. Average FEC over this time period was significantly greater by 63% in one of these three lines whereas there was no difference from the control in the other two body weight lines. The two fleece weight lines were 10-11% heavier in March-May, with 34-35% heavier yearling fleece weights, than their respective controls, whereas average FEC was significantly greater (by 35 and 46%) in both selection lines. Significant correlated increases in estimated food intake were recorded in all three body weight lines and in one of the two fleece weight lines, and these increases were proportional to the liveweight response. The implications of the correlated responses and their variability are discussed.

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“…In contrast, a single dose of anthelmintics that occurs while the treated ewes remain on contaminated grazing has remained unsatisfactory regarding the reduction in pasture contamination (Taylor et al ., ). It has been proposed that the prolonged activity of MXD may be beneficial to those flocks in which treatment of periparturient ewes is practiced, possibly reducing the frequency of lamb treatment (Taylor et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Plasma disposition kinetics of moxidectin after subcutaneous administration to pregnant sheep

Pérez

Núñez

Palma

et al. 2014

Vet Pharm & Therapeutics

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The plasma kinetic profile of moxidectin (MXD) in ewes during the last third of pregnancy was studied after the subcutaneous dose of 0.2 mg/kg of body weight (bw). Two groups of sheep (n = 7) that were equally balanced in body weight were used. Group I (control) was maintained unmated, while Group II (pregnant) was estrous-synchronized and mated with fertile rams. Both groups were maintained under similar conditions regarding management and feeding. When the ewes from Group II fulfilled 120 days of pregnancy, both groups were treated with a subcutaneous injection of 0.2 mg of MXD/kg bw. Blood samples were collected at different set times between 1 h and 40 days post-treatment. After plasma extraction and derivatization, the samples were analyzed using high-performance liquid chromatography with fluorescence detection. A noncompartmental pharmacokinetic analysis was performed, and the data were compared using Student's t-test. The mean pharmacokinetic parameters, including Cmax , Tmax , and the area under the concentration-time curve (AUC), were similar for both groups of sheep. The average of elimination half-life was significantly lower (P = 0.0023) in the pregnant (11.49 ± 2.2 days) vs. the control (17.89 ± 4.84 days) sheep. Similarly, the mean residence time (MRT) for the pregnant group (20.6 ± 3.8 days) was lower (P = 0.037) than that observed in the control group (27.4 ± 9.1 days). It is concluded that pregnancy produces a significant decrease in mean values of half-life of elimination of MXD, indicating that pregnancy can increase the rate of elimination of the drug reducing their permanence in the body.

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Prophylactic efficacy of moxidectin for periparturient ewes and mid-summer lambs

Cited by 20 publications

References 0 publications

Antti Oksanen; Endectocide treatment of the reindeer

Antti Oksanen; Endectocide treatment of the reindeer

Faecal egg count and food intake comparisons of Romney single‐trait selection and control lines

Plasma disposition kinetics of moxidectin after subcutaneous administration to pregnant sheep

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