Prophylactic Efficacy of Coriandrum sativum (Coriander) on Testis of Lead-Exposed Mice

Abstract

Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total protein, and tissue lead level. This was accompanied by simultaneous increase in the activities of LPO, AST, ALT, ACP, ALP, and cholesterol level. Serum testosterone level and sperm density were suppressed in lead-treated group compared with the control. These influences of lead were prevented by concurrent daily administration of C. sativum extracts to some extent. Treating albino mice with lead-induced various histological changes in the testis and treatment with coriander led to an improvement in the histological testis picture. The results thus led us to conclude that administration of C. sativum significantly protects against lead-induced oxidative stress. Further work need to be done to isolate and purify the active principle involved in the antioxidant activity of this plant.

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

“…Subsequently, the extract was subjected to fractionation and its activity as chelating agent was tested, as proposed by Rondina et al, (1991). To evaluate the biological activity of C. sativum as a chelating agent and to find a natural treatment that is less invasive than synthetic products, we developed A. salina lethality to determine the LD 50 This was done because this technique has a potential correlation with specific toxicity tests (McLaughlin, 1998) and is based on the suggestion of WHO (2002) for natural products safety. In this paper, we found a LD 50 > 1,000 mg/mL for C. sativum methanol extract.…”

Lead acetate induced oxidative stress and its possible reversal by Tribulus terrestris root extract in testes of Swiss albino mice

“…The study revealed a highly significant (P<0.001) reduction in protein level in lead intoxicated mice (Fig.3). Lead is multifactorial and directly interrupts enzyme activation, competitively inhibits trace mineral absorption, binds to sulfhydryl proteins (interrupting structural protein synthesis), alters calcium homeostasis, and lowers the level of available sulfhydryl antioxidant reserves in the body [25]. Moreover, lead disturbs intracellular Ca 2+ homeostasis and damages the endoplasmic reticulum, which in turn results in reduction of protein synthesis [26].…”

Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study

“…In another study by Sharma et al (18), rats were administered lead nitrate for 7 days. Biochemical tests afterwards showed a significant increase in PC and a significant decrease in SOD level.…”