Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study

Abstract

Abstract. Lead causes damage to the whole body by inducing oxidative stress. This includes the testis, in which spermatogenesis is affected. Etlingera elatior, a consumable plant that is being extensively studied for its high anti-oxidant properties, was tested against the effect of lead acetate in experimental rats. Rats were divided into groups consisting of a control, lead acetate only, Etlingera elatior treatment only, concurrent treatment of lead acetate and Etlingera elatior, post-treatment of lead acetate followed by Etlingera elatior and preventive group of Etlingera elatior followed by lead acetate. The substances were administered for 14 days and the effects were measured by protein carbonyl content (PCC), superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity in the testis, as well as the testosterone level in the serum. Histological changes in the testis were also observed. Results showed that Etlingera elatior induced a significant reduction in the testis PCC activity, while at the same time it significantly increased the activities of SOD and GPx in the testis, and the testosterone level in the serum. Etlingera elatior also improved the histology of the testis when compared to the lead acetate-treated group. On the whole, Etlingera elatior is effective against oxidative damage caused by lead acetate in the testis.

Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract

“…A study demonstrated that lead causes a high protein carbonyl content (PCC) which is indicative of oxidative damage and low antioxidant levels (6). Lead inhibits osteoclastic bone resorption and osteoblastic bone formation and may lead to early osteoporosis (7). Lead causes multiple types of damage to the bone and bone marrow and therefore it is important to identify a method of ameliorating this toxicity.…”

Chemical Elucidation, Microbial Growth and Free Radical Inhibitory Effects of Dennettia tripetala Fruit: In vitro and In vivo Model Experiments

“…The inhibitory effect of urease by both components are thought to be facilitated by both hydrophobic and hydrogen bond interactions between the amino acid residues of the enzyme's active site, 57 Aside, the nutritional significance affiliated to these active compounds, their synergestic system in vivo, have been shown to mediate decrease in serum lipoprotein (LDL) cholesterol contents and boost high-density lipoprotein (HDL) cholesterol contents in animal studies. 58 In vitro investigation of the free radicals potencies of hexane and methanol fruit extracts of D. tripatela using two known radical models (DPPH and ABTS) (Table 3), displayed noteworthy antioxidant abilities with IC50 values; 3.86 and 4.01 µg/mL against DPPH assay and 4.53 and 4.79 µg/mL as against ABTS assay, respectively. The IC50 value of the hexane extract (3.86 µg/mL) was found to be lower than the ethanol extract (4.01 µg/mL) in the DPPH assay and same for the ABTS assay.…”

Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis with regard to androgen receptor expression in rats

“…Previous researches reported Pb-prompted reproductive system oxidative burden along with subsequently disrupted steroidogenesis and spermatogenesis in humans and animals (Haw et al 2012; Udefa et al 2020).…”