Prophylactic Effect of Probiotic Strains Bifidobacterium Animalis VKL and VKB on Stress-Induced Lesions in the Gastric Mucosa of Rats

Combined Lycium barbarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin in rats

“…Increased Bifidobacterium by both LBP and CPC could be a source of potential beneficial bacteria in the stomach for the host’s health. The genus Bifidobacterium had protective effects on damaged gastric or intestinal mucosa in rats [ 60 , 61 ] and humans [ 62 ]. Prophylactic administration of Bifidobacterium animalis VKL and VKB mixture for 14 days effectively protected against the development of ulcerative lesions in gastric mucosa caused by water immersion restraint stress in rats via preventing the degradation of mucus barrier [ 60 ].…”

“…The genus Bifidobacterium had protective effects on damaged gastric or intestinal mucosa in rats [ 60 , 61 ] and humans [ 62 ]. Prophylactic administration of Bifidobacterium animalis VKL and VKB mixture for 14 days effectively protected against the development of ulcerative lesions in gastric mucosa caused by water immersion restraint stress in rats via preventing the degradation of mucus barrier [ 60 ]. The incidence of ileal ulcer developed by 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl) thiophene (BFMeT, a NSAID) in rats was decreased by oral administration of Bifidobacterium adolescentis in drinking water through inhibiting the growth of aerobic bacteria in the ileum and decreasing the production of lipid peroxides in ileal mucosa [ 61 ].…”

Еffects of Mono-, Poly- And Composite Probiotics on the Ulceration Caused by Restraint Stress

“…Отже, дослідження участі пробіотичних штамів, які здатні відновлювати порушені мікробіоцено-зи травного тракту, у підтриманні гомеостазу СОШ є без сумніву актуальним. Раніше нами був встановлений профілактичний вплив суміші пробіотичних штамів Bifidobacterium animalis VKL та Вifidobacterium animalis VKB на ерозивно-виразкові ураження в шлунку щурів, викликані стресом [5]. Проте є пові-домлення, що пробіотичні бактерії, особли-во роду Lactobacillus, швидко колонізують СОШ після утворення виразки [6,7].…”