Prophylactic Effect of Pentoxifylline on Radiotherapy Complications: A Clinical Study

Aygenç, Erdinç; Celikkanat, Serdar; Kaymakçı, Mustafa; Aksaray, Ferdi; Özdem, Cafer

doi:10.1016/j.otohns.2003.08.015

Cited by 69 publications

(54 citation statements)

References 20 publications

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“…Twenty-six of the preventive trials were rcts 2,16-25, 27-32,34-37, [41][42][43][44]46 , six were nonrandomized clinical trials 3,26,33,38,39,45 , and one was a retrospective trial 40 . Twenty-one of the trials were open 3,16,19,20,24-26, 28,29,32-35,37-43,45 , three were single-blind 17,22,27 , and nine were double-blind 2,18,21,23,30,31,36,44,46 .…”

Section: Resultsmentioning

confidence: 99%

“…Skin reactions were often assessed by one evaluator, which was commonly a radiation oncologist, dermatologist, research nurse, research assistant, radiation therapist, principal investigator, or other medical professional 3,17,20,21,24,26,27,32,33,35,39,44,46,50 . A few studies incorporated an inter-rater reliability measure by having more than one evaluator assess the skin reactions 23,34,36,45,49,51 ; the remaining studies did not describe who assessed the radiated area or areas 2,16,19,25,28,30,31,38,[41][42][43]47,48 .…”

Section: Resultsmentioning

confidence: 99%

“…The second most common tool in use was the U.S. National Cancer Institute's Common Toxicity Criteria (nci ctc), which is similar to the rtog and was used in nine studies 2,3,26,28,30,[37][38][39]46 . The remaining studies used a study-designed tool closely modeled after either the rtog or nci tool, with slight variations [18][19][20]23,31,43,49 .…”

Section: Resultsmentioning

confidence: 99%

“…Neither trial identified a difference in pain or itching between the two groups. Pentoxifylline: One study by Aygenc et al 43 assessed the effect of prophylactic pentoxifylline on radiation-induced toxicities. Pentoxifylline is a drug that is currently used to treat a variety of vasoocclusive disorders.…”

Section: Systemic Interventionsmentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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Radiation therapy is a common treatment for cancer patients. One of the most common side effects of radiation is acute skin reaction (radiation dermatitis) that ranges from a mild rash to severe ulceration. Approximately 85% of patients treated with radiation therapy will experience a moderate-to-severe skin reaction. Acute radiation-induced skin reactions often lead to itching and pain, delays in treatment, and diminished aesthetic appearance-and subsequently to a decrease in quality of life.Surveys have demonstrated that a wide variety of topical, oral, and intravenous agents are used to prevent or to treat radiation-induced skin reactions. We conducted a literature review to identify trials that investigated products for the prophylaxis and management of acute radiation dermatitis. Thirty-nine studies met the pre-defined criteria, with thirty-three being categorized as prophylactic trials and six as management trials.For objective evaluation of skin reactions, the Radiation Therapy Oncology Group criteria and the U.S. National Cancer Institute Common Toxicity Criteria were the most commonly used tools (65% of the studies). Topical corticosteroid agents were found to significantly reduce the severity of skin reactions; however, the trials of corticosteroids evaluated various agents, and no clear indication about a preferred corticosteroid has emerged. Amifostine and oral enzymes were somewhat effective in preventing radiation-induced skin reactions in phase ii and phase iii trials respectively; further large randomized controlled trials should be undertaken to better investigate those products. Biafine cream (Ortho-McNeil Pharmaceuticals, Titusville, NJ, U.S.A.) was found not to be superior to standard regimes in the prevention of radiation-induced skin reactions (n = 6).In conclusion, the evidence is insufficient to support the use of a particular agent for the prevention and management of acute radiation-induced skin reactions. Future trials should focus on comparing agents and approaches that, in phase i and ii trials, suggest efficacy. These future phase iii randomized controlled trials must clearly distinguish between preventive and management strategies for radiation-induced dermatitis. Only then can evidence-based guidelines be developed, with the hope of standardizing the approach across centres and of improving the prevention and management of radiation-induced dermatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Systemic Interventionsmentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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“…Pentoxifylline is a nonspecific PDE-5 inhibitor used for a wide range of medical applications. It has been used in kidney transplants, open heart surgery, dermatological conditions and radiation-induced fibrosis as a means of decreasing inflammation and fibrosis [57][58][59][60][61][62] and is commonly used to treat claudication and symptomatic cerebral atherosclerosis. 63 The potential benefit of pentoxifylline is predicated on data from in vitro and in vivo models.…”

Section: Historymentioning

confidence: 99%

Peyronie's disease: a critical appraisal of current diagnosis and treatment

2008

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Peyronie's disease is a fibrotic disorder of the tunica albuginea of the penis resulting in varying degrees of penile curvature and sexual dysfunction. Diagnosis of the disorder is made by detailed sexual history and focused physical examination. A wide range of medical treatments has been employed to treat the disorder. Verapamil treatment administered by intraplaque injection is supported by generally consistent randomized controlled trials (RCT). Some RCT evidence exists to support the use of colchicine, potaba, L-carnitine and liposomal superoxide dismutase. Future studies of medical efficacy should focus on improving RCT design, implementation and results reporting to improve the quality of evidence generated by each study. The surgical treatment of Peyronie's disease is a viable and recommended alternative for men with compromised sexual function due to severe curvature or lesions causing penile instability. The choice of corrective procedure should be tailored to each patient after a detailed evaluation of disease severity and sexual function.

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Radiation‐Induced Skin Reactions

Wong

Kassam

2013

Dermatologic Principles and Practice in Oncology

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Prophylactic Effect of Pentoxifylline on Radiotherapy Complications: A Clinical Study

Abstract: Our study suggests that Ptx has a prophylactic effect on the radiation complications. This can be explained by protective effect of Ptx against vascular pathology.

Cited by 69 publications

References 20 publications

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Peyronie's disease: a critical appraisal of current diagnosis and treatment

Radiation‐Induced Skin Reactions

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