Prophylactic drug management for febrile seizures in children

Management of simple febrile seizures

“…In those deemed desirable, intermittent use of anticonvulsants during early stages of a febrile illness is described to reduce the risk of recurrence of FS. Oral or rectal diazepam and oral clobazam are those that have been trialled as intermittent therapies 22 . It is best recommended to be used on a selective policy in those with increased risk of recurrence 21 .…”

“…It is best recommended to be used on a selective policy in those with increased risk of recurrence 21 . Some studies have shown reduced recurrences with diazepam but in others the findings were controversial 22 . It is not beneficial in those with low risk for recurrence 21 .…”

“…21 . The doses and the duration of diazepam in these studies varied from 0.2 mg/kg/day to 1 mg/kg/day and 48 hours to entire duration of the febrile illness respectively 22 . Considering the above factors of side effects and the number needed to treat to prevent a recurrence in the context of a rather benign condition (where there will be no permanent damage and eventual spontaneous remission) prophylaxis for simple FS recurrence is not recommended .…”

The Meaning of Fever in Children

“…Такие судороги генетически детерминированы, развиваются у 2-4% детей в воз-расте старше 1 мес, обычно не сопровождаются эпи-лептической активностью головного мозга, не влия-ют на дальнейшее развитие ребенка и не повторяются после 6 лет. В 50-70% фебрильные судороги бывают однократными, однако в случае их наличия в анамнезе ребенку могут быть рекомендованы жаропонижающие средства при более низких цифрах лихорадки [8,9].…”

“…Применение несте-роидных противовоспалительных средств ассоцииро-вано с некоторым риском развития тяжелой инфекции кожи и мягких тканей [3,9,20].…”