Prophylactic drug management for febrile seizures in children

Febrile seizures:

“…These interventions were the subject of a Cochrane review in 2012. 65 Randomised trials were reviewed and outcomes assessed as seizure recurrence rates at ages of 6, 12, 18, 24, and 36 months and at 5-6 years in intervention and non-intervention groups. Intervention groups included children who received antipyretics or antiepileptic drugs either intermittently (only at times of fever recurrence) or, in the case of antiepileptics, as continuous prophylaxis.…”

“…No benefit has been shown for the use of Intermittent clobazam versus placebo at 6 months showed an apparent benefit, but in the control group the recurrence rate of febrile seizures was extremely high at 83.3%, and this result therefore needs replication. 65 More importantly, adverse medication effects were found in up to 30% of recipients.…”

A study of treatment patterns in symptomatic management of fever in children (antipyresis) among Pediatricians

“…Febrile seizure is a rare complication of fever that occurs in 2-4% of febrile children and most are self-limited without any long-term sequelae [16,17,18]. Despite there being no evidence to suggest that brain damage may occur after febrile convulsion, in the present study 30% of the doctors believed that brain damage might occur after febrile convulsion.…”

“…There are also other articles that surveyed primary care practitioners' opinions and behaviors with regards to fever, which confirm that fever is seen as a risk factor for brain damage. Unfortunately, health care providers and parents believe that brain damage is a consequence of fever [16,17,18].…”

Febrile seizures in children: benefits and risks of prophylactic drug management

“…Drug options for preventing recurrence of febrile seizures in children have been assessed in an updated Cochrane systematic review 1. Febrile seizures affect between 3% and 8% of children up to the age of 7 years, and recur in up to 30% during subsequent illnesses 2.…”