Prophylactic cognitive enhancers for improvement of cognitive function in patients undergoing electroconvulsive therapy

Niu, Yunlian; Ye, Dan; You, Yijie; Wu, Jian

doi:10.1097/md.0000000000019527

Cited by 9 publications

(7 citation statements)

References 25 publications

(37 reference statements)

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“…In the donepezil group, faster post-ECT cognitive recovery was observed in comparison to the placebo group. In line with our study, a meta-analysis indicated that cognitive enhancers might improve cognitive function and decrease cognitive side-effects induced by ECT (25).…”

Section: Discussionsupporting

confidence: 91%

Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial

Zarean

Sedehi

Heshmati

2021

Iran J Psychiatry Behav Sci

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Background: Electroconvulsive therapy (ECT) is an effective strategy in the treatment of mood disorders; however, it is associated with some cognitive complications. Objectives: This study aimed to evaluate the efficacy of donepezil as an acetylcholinesterase inhibitor in improving cognitive impairment induced by ECT in mood disorder patients. Methods: Ninety-six mood disorder patients were randomly assigned to the donepezil (5mg/day) or placebo groups. The Persian versions of the Mini-Mental Status examination (MMSE) and Addenbrooke’s Cognitive Examination Revised (ACE-R) were used to evaluate cognitive performance before the first ECT session, after the fourth ECT session, and four weeks after the last ECT session. Results: The mean scores of MMSE and ACE-R revealed significant improvement in the donepezil group over time (P < 0.001). All ACE-R subscales increased significantly following the intervention implementation in the donepezil group (P < 0.001). Furthermore, the donepezil group reported no remarkable complications and completed the study. Conclusions: Donepezil co-administration with ECT may improve the ECT-induced cognitive disturbances.

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Section: Discussionsupporting

confidence: 91%

Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial

Zarean

Sedehi

Heshmati

2021

Iran J Psychiatry Behav Sci

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“…These AEs may be seizure-related, such as prolonged and tardive seizures and status epilepticus, AEs due to muscle relaxants such as prolonged apnea, malignant hypothermia, hyperkalemia, and awareness of neuromuscular paralysis, cardiovascular AEs, such as asystole, raised blood pressure, myocardial infarction, and cardiomyopathy, as well as cognitive AEs such as amnesia and memory loss ( Andrade et al, 2016 ). Regarding the widespread experience of disabled cognition after ECT, it has been proven extensively that ECT may cause cognitive dysfunction but that this condition is reversible and not life-threatening ( Semkovska and McLoughlin, 2010 ; Ziegelmayer et al, 2017 ; Landry et al, 2021 ), and that cognitive enhancer may reduce ECT-induced cognitive side effects ( Niu et al, 2020 ). Meta-analyses suggest that new learning is impaired immediately following ECT but that group means to return at least to baseline by 14 days after ECT.…”

Section: Discussionmentioning

confidence: 99%

Risk Assessment of Electroconvulsive Therapy in Clinical Routine: A 3-Year Analysis of Life-Threatening Events in More Than 3,000 Treatment Sessions

Hajak

Hajak²,

Ziegelmayer³

et al. 2021

Front. Psychol.

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Background: Extensive research has reported that electroconvulsive therapy (ECT) can be highly effective in approximately 80% of patients suffering from depression. Its clinical use is mainly limited by historical objections and the concern about unwanted adverse effects (AEs), including serious and potentially life-threatening adverse events (pLTAEs), induced either by ECT or by anesthesia. Objective risk estimation is, therefore, a decisive factor in determining an indication for ECT.Methods: This paper presents a retrospective analysis of 3-year safety protocols and patient files of 157 patients who received a total of 3,106 ECT applications in a psychiatric inpatient setting at a psychiatric community hospital. This patient group comprises 5.3% of inpatients admitted with comparable diagnoses. Adverse events were analyzed from standardized safety protocols and patient files with a focus on pLTAEs.Results: Adverse events were reported for 30 (19.1%) of the 157 participants during 39 (6.1%) of 641 hospital stays. Serious pLTAEs occurred during three electroconvulsive stimulations in three patients, who needed action through the administration of medication or mechanical respiration. No patient suffered permanent damage to health, and no patient died. The incidence of these and other AEs was independent of sex, age, and diagnosis of patients, and anesthesia medication. Minor AEs occurred more often with higher stimulus doses and an increasing number of treatments.Conclusion: The low incidence rate of 0.097% of serious pLTAEs that require medical action may allow the conclusion that ECT is a rather safe treatment when performed in a controlled setting. The beneficial risk profile of ECT performed in the standard care of psychiatric hospitals suggests a more generous indication of this treatment method. We recommend that ECT facilities collect individual safety data to allow a reliable judgment of their institutional ECT risk profile.

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“…Wynik chińskiego badania z 2020 roku przeprowadzonego prze Niu i wsp. [47] wskazał na możliwość zastosowania memantyny jako środka już nie tylko doraźnego, ale profilaktycznego po procedurze EW [47]. W tym samym roku w irańskim badaniu porównano zastosowanie memantyny z melatoniną, zdecydowanie wskazując na tą pierwszą pod kątem łagodzenia deficytów poznawczych [48].…”

Section: Możliwości łAgodzenia Zaburzeń Poznawczych Po Ewunclassified

Terapia elektrowstrząsowa i jej wpływ na funkcje poznawcze – przegląd piśmiennictwa

2021

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Prophylactic cognitive enhancers for improvement of cognitive function in patients undergoing electroconvulsive therapy

Abstract: Supplemental Digital Content is available in the text

Cited by 9 publications

References 25 publications

Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial

Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial

Risk Assessment of Electroconvulsive Therapy in Clinical Routine: A 3-Year Analysis of Life-Threatening Events in More Than 3,000 Treatment Sessions

Terapia elektrowstrząsowa i jej wpływ na funkcje poznawcze – przegląd piśmiennictwa

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