Prophylactic antiemetic effect of midazolam after middle ear surgery

Abstract

Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.

Retracted: Antiemetic Efficacy of Low‐Dose Midazolam in Patients Undergoing Thyroidectomy

“…The dose of midazolam was chosen because of previous reports that midazolam 50 to 75 µg/kg decreases the incidence of PONV after middle ear surgery or strabismus surgery. [13][14][15] No patients were given preanesthetic medication. Anesthesia was induced with propofol 2 mg/kg IV and fentanyl 2 µg/kg; vecuronium 0.1 mg/kg IV was used to facilitate tracheal intubation.…”

“…10,11 Midazolam is a short-acting benzodiazepine with a rapid onset of action that is used for induction of general anesthesia and preoperative sedation. 12 Previously, midazolam 50 to 75 µg/kg was reported to be effective for preventing PONV in adults undergoing middle ear surgery without delaying emergency from anesthesia or excessive sedation 13,14 and in children undergoing strabismus surgery without prolonged length of postoperative stay. 15 However, there have been no reports that have evaluated the antiemetic efficacy of low-dose midazolam in patients undergoing thyroidectomy.…”

Antiemetic Efficacy of Dexamethasone Combined with Midazolam after Middle Ear Surgery

“…[2][3][4] In this study, the incidence of PONV occurred in 26 (65%) of patients in the saline group, which was consistent with previous reports. [2][3][4] The etiology of PONV remains unclear, but is probably multifactorial. The risk factors include sex (female population), nonsmoking status, past history of motion sickness and/or previous PONV, anesthetic and surgical factors, pain, and perioperative use of opioids.…”

A prospective controlled study to assess the antiemetic effect of midazolam following intragastric balloon insertion

“…He showed that adding midazolam to ramosetron had no advantages compared to ramosetron alone in reducing the incidence of PONV in patients undergoing strabismus surgery. [14] Contrary to our results, Jung et al .,[15] used midazolam in similar dose of 0.075 mg/kg after induction in middle ear surgery. They found that the incidence of nausea and vomiting significantly decreased compared to placebo.…”