Antiemetic Efficacy of Dexamethasone Combined with Midazolam after Middle Ear Surgery

Abstract

The combination of dexamethasone and midazolam was better than dexamethasone alone in reducing the incidence of vomiting and the rescue antiemetic requirements in women patients undergoing middle ear surgery. However, this combination treatment did not significantly decrease the overall incidence of nausea and vomiting compared with the use of dexamethasone alone.

Retracted: Antiemetic Efficacy of Low‐Dose Midazolam in Patients Undergoing Thyroidectomy

“…10,11 Midazolam is a short-acting benzodiazepine with a rapid onset of action that is used for induction of general anesthesia and preoperative sedation. 12 Previously, midazolam 50 to 75 µg/kg was reported to be effective for preventing PONV in adults undergoing middle ear surgery without delaying emergency from anesthesia or excessive sedation 13,14 and in children undergoing strabismus surgery without prolonged length of postoperative stay. 15 However, there have been no reports that have evaluated the antiemetic efficacy of low-dose midazolam in patients undergoing thyroidectomy.…”

Comparison of ramosetron with combined ramosetron and midazolam for preventing postoperative nausea and vomiting in patients at high risk following laparoscopic gynaecological surgery

“…The combination of dexamethasone and midazolam reduced the incidence of vomiting and the rescue antiemetic requirements, but did not decrease the total incidence of nausea and vomiting, compared with the use of dexamethasone alone, in female patients undergoing middle-ear surgery. 17 Combined midazolam and ramosetron had no advantages compared with ramosetron alone in reducing the incidence of PONV in children undergoing strabismus surgery. 18 Several important risk factors associated with PONV are female sex, nonsmoking status, history of PONV or motion sickness, age, duration of anaesthesia and use of postoperative opioids.…”

“…25 It was reported that midazolam administered 30 min before the end of surgery was more effective in decreasing the incidence of PONV than midazolam given 15 min before induction of anaesthesia, in patients who had undergone lower abdominal surgery lasting 1-2 h. 12 In previous studies, doses of midazolam for preventing PONV were 35-75 mg/kg. 11,12,17,24 Watcha and White 21 recommended the use of minimally effective doses of antiemetic drugs to reduce the incidence of sedation and other deleterious side-effects, and potent nonopioid analgesics such as ketorolac can be used to avoid some opioid-related adverse effects. The present study used 50 mg/kg of midazolam and (as a rescue analgesic) ketorolac; the incidence of adverse events did not differ significantly among the three treatment groups.…”

“…11 However, several studies have reported controversial findings associated with the use of midazolam in combination with antiemetics. 17,18 Furthermore, it has been reported that midazolam given 30 min before the end of surgery was more effective than premedication with midazolam at decreasing the incidence of PONV. 12 We hypothesized that ramosetron combined with midazolam would be more effective in reducing the incidence of PONV than ramosetron administered alone, following laparoscopic gynaecological surgery in patients at high risk of PONV.…”

Minimum effective dose of dexamethasone in combination with midazolam as prophylaxis against postoperative nausea and vomiting after laparoscopic cholecystectomy

“…showed that the combination of 10 mg D and 0.075 mg/kg M was better than D alone in reducing the incidence of vomiting in female patients undergoing middle ear surgery under general anaesthesia. [ 26 ] Riad et al . concluded that prophylactic M 0.05 mg/kg with or without D 0.5 mg/kg reduces the incidence of PONV in children undergoing strabismus repair.…”